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Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle.

Borgdorff MA, Bartelds B, Dickinson MG, Boersma B, Weij M, Zandvoort A, Silljé HH, Steendijk P, de Vroomen M, Berger RM.

Eur J Heart Fail. 2012 Sep;14(9):1067-74. doi: 10.1093/eurjhf/hfs094. Epub 2012 Jun 22.


Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload.

Borgdorff MA, Bartelds B, Dickinson MG, van Wiechen MP, Steendijk P, de Vroomen M, Berger RM.

Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H361-9. doi: 10.1152/ajpheart.00843.2013. Epub 2014 May 30.


Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling.

Schäfer S, Ellinghaus P, Janssen W, Kramer F, Lustig K, Milting H, Kast R, Klein M.

Cardiovasc Res. 2009 Apr 1;82(1):30-9. doi: 10.1093/cvr/cvp002. Epub 2009 Jan 8.


Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction: the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial.

Andersen MJ, Ersbøll M, Axelsson A, Gustafsson F, Hassager C, Køber L, Borlaug BA, Boesgaard S, Skovgaard LT, Møller JE.

Circulation. 2013 Mar 19;127(11):1200-8. doi: 10.1161/CIRCULATIONAHA.112.000056. Epub 2013 Feb 13.


Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study.

Guazzi M, Vicenzi M, Arena R, Guazzi MD.

Circulation. 2011 Jul 12;124(2):164-74. doi: 10.1161/CIRCULATIONAHA.110.983866. Epub 2011 Jun 27.


Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.

Xie YP, Chen B, Sanders P, Guo A, Li Y, Zimmerman K, Wang LC, Weiss RM, Grumbach IM, Anderson ME, Song LS.

Hypertension. 2012 Feb;59(2):355-62. doi: 10.1161/HYPERTENSIONAHA.111.180968. Epub 2011 Dec 27.


Acute effect of sildenafil on central hemodynamics in mechanically ventilated patients with WHO group III pulmonary hypertension and right ventricular failure necessitating administration of dobutamine.

Karakitsos D, Papanikolaou J, Karabinis A, Alalawi R, Wachtel M, Jumper C, Alexopoulos D, Davlouros P.

Int J Cardiol. 2013 Aug 10;167(3):848-54. doi: 10.1016/j.ijcard.2012.02.006. Epub 2012 Mar 3.


Sildenafil and diastolic dysfunction after acute myocardial infarction trial: rationale and design.

Andersen MJ, Gustafsson F, Hassager C, Køber L, Møller JE.

Clin Cardiol. 2013 Apr;36(4):179-83. doi: 10.1002/clc.22103. Epub 2013 Feb 28.


Sildenafil preserves lung endothelial function and prevents pulmonary vascular remodeling in a rat model of diastolic heart failure.

Yin J, Kukucka M, Hoffmann J, Sterner-Kock A, Burhenne J, Haefeli WE, Kuppe H, Kuebler WM.

Circ Heart Fail. 2011 Mar;4(2):198-206. doi: 10.1161/CIRCHEARTFAILURE.110.957050. Epub 2011 Jan 7. Erratum in: Circ Heart Fail. 2011 May 1;4(3):e13.


Acute and chronic response of the right ventricle to surgically induced pressure and volume overload--an analysis of pressure-volume relations.

Yerebakan C, Klopsch C, Niefeldt S, Zeisig V, Vollmar B, Liebold A, Sandica E, Steinhoff G.

Interact Cardiovasc Thorac Surg. 2010 Apr;10(4):519-25. doi: 10.1510/icvts.2009.221234. Epub 2010 Jan 20.


Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat.

Hessel MH, Steendijk P, den Adel B, Schutte CI, van der Laarse A.

Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2424-30. Epub 2006 May 26.


Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart.

Andersen A, Nielsen JM, Peters CD, Schou UK, Sloth E, Nielsen-Kudsk JE.

Eur J Heart Fail. 2008 Dec;10(12):1158-65. doi: 10.1016/j.ejheart.2008.09.016. Epub 2008 Nov 12.


Delayed improvement of right ventricular diastolic function and regression of right ventricular mass after percutaneous pulmonary valve implantation in patients with congenital heart disease.

Romeih S, Kroft LJ, Bokenkamp R, Schalij MJ, Grotenhuis H, Hazekamp MG, Groenink M, de Roos A, Blom NA.

Am Heart J. 2009 Jul;158(1):40-6. doi: 10.1016/j.ahj.2009.04.023.


Chronic Inhibition of cGMP phosphodiesterase 5A improves diabetic cardiomyopathy: a randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging.

Giannetta E, Isidori AM, Galea N, Carbone I, Mandosi E, Vizza CD, Naro F, Morano S, Fedele F, Lenzi A.

Circulation. 2012 May 15;125(19):2323-33. doi: 10.1161/CIRCULATIONAHA.111.063412. Epub 2012 Apr 11.


Differential responses of the right ventricle to abnormal loading conditions in mice: pressure vs. volume load.

Bartelds B, Borgdorff MA, Smit-van Oosten A, Takens J, Boersma B, Nederhoff MG, Elzenga NJ, van Gilst WH, De Windt LJ, Berger RM.

Eur J Heart Fail. 2011 Dec;13(12):1275-82. doi: 10.1093/eurjhf/hfr134. Epub 2011 Oct 24.


Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension.

Lewis GD, Shah R, Shahzad K, Camuso JM, Pappagianopoulos PP, Hung J, Tawakol A, Gerszten RE, Systrom DM, Bloch KD, Semigran MJ.

Circulation. 2007 Oct 2;116(14):1555-62. Epub 2007 Sep 4.


Right and left ventricular function after chronic pulmonary artery banding in rats assessed with biventricular pressure-volume loops.

Faber MJ, Dalinghaus M, Lankhuizen IM, Steendijk P, Hop WC, Schoemaker RG, Duncker DJ, Lamers JM, Helbing WA.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1580-6. Epub 2006 May 5.


S-nitroso human serum albumin attenuates pulmonary hypertension, improves right ventricular-arterial coupling, and reduces oxidative stress in a chronic right ventricle volume overload model.

Rungatscher A, Hallström S, Linardi D, Milani E, Gasser H, Podesser BK, Scarabelli TM, Luciani GB, Faggian G.

J Heart Lung Transplant. 2015 Mar;34(3):479-88. doi: 10.1016/j.healun.2014.09.041. Epub 2014 Oct 13.


Selective PDE5A inhibition with sildenafil rescues left ventricular dysfunction, inflammatory immune response and cardiac remodeling in angiotensin II-induced heart failure in vivo.

Westermann D, Becher PM, Lindner D, Savvatis K, Xia Y, Fröhlich M, Hoffmann S, Schultheiss HP, Tschöpe C.

Basic Res Cardiol. 2012 Nov;107(6):308. doi: 10.1007/s00395-012-0308-y. Epub 2012 Nov 2. Erratum in: Basic Res Cardiol. 2013 Mar;108(2):327.


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