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p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.

Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G.

J Biol Chem. 2012 Aug 10;287(33):27895-905. doi: 10.1074/jbc.M111.335794. Epub 2012 Jun 22.


PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.

Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G.

Cancer Res. 2010 Apr 1;70(7):2901-10. doi: 10.1158/0008-5472.CAN-09-3229. Epub 2010 Mar 23.


The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.

Yin N, Lepp A, Ji Y, Mortensen M, Hou S, Qi XM, Myers CR, Chen G.

J Biol Chem. 2017 Sep 8;292(36):15070-15079. doi: 10.1074/jbc.M117.779488. Epub 2017 Jul 24.


p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.

Kwong J, Hong L, Liao R, Deng Q, Han J, Sun P.

J Biol Chem. 2009 Apr 24;284(17):11237-46. doi: 10.1074/jbc.M808327200. Epub 2009 Feb 27.


Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation.

Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC, Wang AH.

Sci Signal. 2014 Oct 14;7(347):ra98. doi: 10.1126/scisignal.2005722.


p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.

Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G.

J Biol Chem. 2007 Oct 26;282(43):31398-408. Epub 2007 Aug 27.


Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38gamma-dependent signaling pathway.

Sakabe K, Teramoto H, Zohar M, Behbahani B, Miyazaki H, Chikumi H, Gutkind JS.

FEBS Lett. 2002 Jan 30;511(1-3):15-20.


Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ.

Maisonneuve P, Caillet-Saguy C, Vaney MC, Bibi-Zainab E, Sawyer K, Raynal B, Haouz A, Delepierre M, Lafon M, Cordier F, Wolff N.

J Biol Chem. 2016 Aug 5;291(32):16699-708. doi: 10.1074/jbc.M115.707208. Epub 2016 May 31.


p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription.

Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G.

J Biol Chem. 2012 Apr 27;287(18):14681-91. doi: 10.1074/jbc.M112.349357. Epub 2012 Mar 7.


Protein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537.

Suresh PS, Ma S, Migliaccio A, Chen G.

Mol Cancer Ther. 2014 Jan;13(1):230-8. doi: 10.1158/1535-7163.MCT-13-0610. Epub 2013 Nov 13.


Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses.

Töpffer S, Müller-Schiffmann A, Matentzoglu K, Scheffner M, Steger G.

J Gen Virol. 2007 Nov;88(Pt 11):2956-65.


Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer.

Del Reino P, Alsina-Beauchamp D, Escós A, Cerezo-Guisado MI, Risco A, Aparicio N, Zur R, Fernandez-Estévez M, Collantes E, Montans J, Cuenda A.

Cancer Res. 2014 Nov 1;74(21):6150-60. doi: 10.1158/0008-5472.CAN-14-0870. Epub 2014 Sep 12.


Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.

Qi X, Xie C, Hou S, Li G, Yin N, Dong L, Lepp A, Chesnik MA, Mirza SP, Szabo A, Tsai S, Basir Z, Wu S, Chen G.

Oncotarget. 2014 Jun 30;5(12):4269-82.


The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.

Tosti E, Waldbaum L, Warshaw G, Gross EA, Ruggieri R.

J Biol Chem. 2004 Nov 12;279(46):47652-60. Epub 2004 Sep 1.


Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein.

Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK.

J Biol Chem. 1997 Oct 24;272(43):27281-7.


Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons.

Qi X, Hou S, Lepp A, Li R, Basir Z, Lou Z, Chen G.

J Biol Chem. 2011 Oct 14;286(41):35883-90. doi: 10.1074/jbc.M111.229260. Epub 2011 Aug 30.

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