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Items: 1 to 20 of 87

1.

Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection.

Xia J, Wang H, Guo J, Zhang Z, Coder B, Su DM.

Aging Dis. 2012 Jun;3(3):248-59. Epub 2012 May 1.

2.

Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium.

Guo J, Rahman M, Cheng L, Zhang S, Tvinnereim A, Su DM.

J Mol Med (Berl). 2011 Mar;89(3):263-77. doi: 10.1007/s00109-010-0700-8. Epub 2010 Nov 26.

3.

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima RG, Amagai T, Su DM.

J Biol Chem. 2010 Feb 19;285(8):5836-47. doi: 10.1074/jbc.M109.072124. Epub 2009 Dec 2.

4.

Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.

Coder BD, Wang H, Ruan L, Su DM.

J Immunol. 2015 Jun 15;194(12):5825-37. doi: 10.4049/jimmunol.1500082. Epub 2015 May 8.

5.
6.

Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance Induction.

Lopes N, Sergé A, Ferrier P, Irla M.

Front Immunol. 2015 Jul 20;6:365. doi: 10.3389/fimmu.2015.00365. eCollection 2015. Review.

7.

Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution.

Sun L, Guo J, Brown R, Amagai T, Zhao Y, Su DM.

Aging Cell. 2010 Jun;9(3):347-57. doi: 10.1111/j.1474-9726.2010.00559.x. Epub 2010 Mar 12.

8.

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.

Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, Matsumoto M.

J Exp Med. 2008 Nov 24;205(12):2827-38. doi: 10.1084/jem.20080046. Epub 2008 Nov 17.

9.

Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.

Coutinho A, Caramalho I, Seixas E, Demengeot J.

Curr Top Microbiol Immunol. 2005;293:43-71. Review.

PMID:
15981475
10.

Canonical microRNAs in thymic epithelial cells promote central tolerance.

Khan IS, Taniguchi RT, Fasano KJ, Anderson MS, Jeker LT.

Eur J Immunol. 2014 May;44(5):1313-9. doi: 10.1002/eji.201344079. Epub 2014 Mar 20.

11.

The many faces of aire in central tolerance.

Laan M, Peterson P.

Front Immunol. 2013 Oct 11;4:326. doi: 10.3389/fimmu.2013.00326. Review.

12.

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y.

Immunity. 2008 Sep 19;29(3):438-50. doi: 10.1016/j.immuni.2008.06.018.

13.

Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis.

Campbell IK, Kinkel SA, Drake SF, van Nieuwenhuijze A, Hubert FX, Tarlinton DM, Heath WR, Scott HS, Wicks IP.

Arthritis Rheum. 2009 Jun;60(6):1683-93. doi: 10.1002/art.24501.

14.

Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging.

Guo J, Feng Y, Barnes P, Huang FF, Idell S, Su DM, Shams H.

PLoS One. 2012;7(4):e34681. doi: 10.1371/journal.pone.0034681. Epub 2012 Apr 13.

15.

Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

Ohigashi I, Zuklys S, Sakata M, Mayer CE, Zhanybekova S, Murata S, Tanaka K, Holländer GA, Takahama Y.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9885-90. doi: 10.1073/pnas.1301799110. Epub 2013 May 29.

16.

Models of aire-dependent gene regulation for thymic negative selection.

Danso-Abeam D, Humblet-Baron S, Dooley J, Liston A.

Front Immunol. 2011 May 9;2:14. doi: 10.3389/fimmu.2011.00014. eCollection 2011.

17.

Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity.

Fletcher AL, Seach N, Reiseger JJ, Lowen TE, Hammett MV, Scott HS, Boyd RL.

J Immunol. 2009 Mar 1;182(5):2690-9. doi: 10.4049/jimmunol.0801752.

18.

Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla.

Nishijima H, Kitano S, Miyachi H, Morimoto J, Kawano H, Hirota F, Morita R, Mouri Y, Masuda K, Imoto I, Ikuta K, Matsumoto M.

J Immunol. 2015 Nov 15;195(10):4641-9. doi: 10.4049/jimmunol.1501026. Epub 2015 Oct 9.

19.

[Function of Aire in central and peripheral immune tolerance].

Hanafusa T.

Nihon Rinsho Meneki Gakkai Kaishi. 2014;37(3):133-8. Review. Japanese.

20.

Disruption of immunological tolerance: role of AIRE gene in autoimmunity.

Rizzi M, Ferrera F, Filaci G, Indiveri F.

Autoimmun Rev. 2006 Feb;5(2):145-7. Epub 2005 Sep 13. Review.

PMID:
16431348

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