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Items: 1 to 20 of 56

1.

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments.

Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ.

Cancer Res. 2012 Aug 15;72(16):3938-47. doi: 10.1158/0008-5472.CAN-11-3881. Epub 2012 Jun 19.

2.

Autophagy on acid.

Wojtkowiak JW, Gillies RJ.

Autophagy. 2012 Nov;8(11):1688-9. doi: 10.4161/auto.21501. Epub 2012 Aug 9.

3.

Autophagy is a protective mechanism for human melanoma cells under acidic stress.

Marino ML, Pellegrini P, Di Lernia G, Djavaheri-Mergny M, Brnjic S, Zhang X, Hägg M, Linder S, Fais S, Codogno P, De Milito A.

J Biol Chem. 2012 Aug 31;287(36):30664-76. doi: 10.1074/jbc.M112.339127. Epub 2012 Jul 3.

4.

Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment.

Rausch V, Liu L, Apel A, Rettig T, Gladkich J, Labsch S, Kallifatidis G, Kaczorowski A, Groth A, Gross W, Gebhard MM, Schemmer P, Werner J, Salnikov AV, Zentgraf H, Büchler MW, Herr I.

J Pathol. 2012 Jul;227(3):325-35. doi: 10.1002/path.3994. Epub 2012 Apr 18.

PMID:
22262369
5.

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies.

Pellegrini P, Strambi A, Zipoli C, Hägg-Olofsson M, Buoncervello M, Linder S, De Milito A.

Autophagy. 2014 Apr;10(4):562-71. doi: 10.4161/auto.27901. Epub 2014 Jan 31.

6.

Acid-induced autophagy protects human lung cancer cells from apoptosis by activating ER stress.

Xie WY, Zhou XD, Li Q, Chen LX, Ran DH.

Exp Cell Res. 2015 Dec 10;339(2):270-9. doi: 10.1016/j.yexcr.2015.11.005. Epub 2015 Nov 10.

PMID:
26559141
7.

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.

Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F.

Cell Cycle. 2010 Sep 1;9(17):3515-33. Epub 2010 Sep 9.

8.

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels.

Parks SK, Mazure NM, Counillon L, Pouysségur J.

J Cell Physiol. 2013 Sep;228(9):1854-62. doi: 10.1002/jcp.24346.

PMID:
23459996
10.

Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells.

Paglin S, Lee NY, Nakar C, Fitzgerald M, Plotkin J, Deuel B, Hackett N, McMahill M, Sphicas E, Lampen N, Yahalom J.

Cancer Res. 2005 Dec 1;65(23):11061-70.

11.

AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro.

Chaachouay H, Fehrenbacher B, Toulany M, Schaller M, Multhoff G, Rodemann HP.

Radiother Oncol. 2015 Sep;116(3):409-16. doi: 10.1016/j.radonc.2015.08.012. Epub 2015 Aug 26.

PMID:
26318663
12.

Autophagic clearance of mitochondria in the kidney copes with metabolic acidosis.

Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Matsuda J, Kitamura H, Niimura F, Matsusaka T, Iwatani H, Matsui I, Kaimori J, Kioka H, Isaka Y, Rakugi H.

J Am Soc Nephrol. 2014 Oct;25(10):2254-66. doi: 10.1681/ASN.2013090986. Epub 2014 Apr 3.

13.

Acidic priming enhances metastatic potential of cancer cells.

Riemann A, Schneider B, Gündel D, Stock C, Thews O, Gekle M.

Pflugers Arch. 2014 Nov;466(11):2127-38. doi: 10.1007/s00424-014-1458-6. Epub 2014 Feb 16.

PMID:
24531759
14.

Modulation of autophagic activity by extracellular pH.

Xu T, Su H, Ganapathy S, Yuan ZM.

Autophagy. 2011 Nov;7(11):1316-22. doi: 10.4161/auto.7.11.17785. Epub 2011 Nov 1.

15.

Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment.

Yang N, Liu C, Peck AR, Girondo MA, Yanac AF, Tran TH, Utama FE, Tanaka T, Freydin B, Chervoneva I, Hyslop T, Kovatich AJ, Hooke JA, Shriver CD, Rui H.

Breast Cancer Res. 2013;15(5):R73.

16.

Acid-mediated tumor invasion: a multidisciplinary study.

Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, Gillies RJ.

Cancer Res. 2006 May 15;66(10):5216-23.

17.

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells.

Akar U, Chaves-Reyez A, Barria M, Tari A, Sanguino A, Kondo Y, Kondo S, Arun B, Lopez-Berestein G, Ozpolat B.

Autophagy. 2008 Jul;4(5):669-79. Epub 2008 Apr 10.

PMID:
18424910
18.

Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer.

Robey IF, Martin NK.

BMC Cancer. 2011 Jun 10;11:235. doi: 10.1186/1471-2407-11-235.

19.

Sonic hedgehog promotes autophagy of vascular smooth muscle cells.

Li H, Li J, Li Y, Singh P, Cao L, Xu LJ, Li D, Wang Y, Xie Z, Gui Y, Zheng XL.

Am J Physiol Heart Circ Physiol. 2012 Dec 1;303(11):H1319-31. doi: 10.1152/ajpheart.00160.2012. Epub 2012 Sep 28.

20.

Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.

Prasad P, Gordijo CR, Abbasi AZ, Maeda A, Ip A, Rauth AM, DaCosta RS, Wu XY.

ACS Nano. 2014 Apr 22;8(4):3202-12. doi: 10.1021/nn405773r. Epub 2014 Apr 4. Erratum in: ACS Nano. 2014 Jun 24;8(6):6510.

PMID:
24702320

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