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Items: 1 to 20 of 110

1.

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.

Dong Z, Davidson D, Pérez-Quintero LA, Kurosaki T, Swat W, Veillette A.

Immunity. 2012 Jun 29;36(6):974-85. doi: 10.1016/j.immuni.2012.03.023. Epub 2012 Jun 7.

2.

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.

Pérez-Quintero LA, Roncagalli R, Guo H, Latour S, Davidson D, Veillette A.

J Exp Med. 2014 Apr 7;211(4):727-42. doi: 10.1084/jem.20132038. Epub 2014 Mar 31.

3.

Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).

Eissmann P, Beauchamp L, Wooters J, Tilton JC, Long EO, Watzl C.

Blood. 2005 Jun 15;105(12):4722-9. Epub 2005 Feb 15.

4.

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.

Chen R, Relouzat F, Roncagalli R, Aoukaty A, Tan R, Latour S, Veillette A.

Mol Cell Biol. 2004 Jun;24(12):5144-56.

5.

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.

Wu N, Zhong MC, Roncagalli R, Pérez-Quintero LA, Guo H, Zhang Z, Lenoir C, Dong Z, Latour S, Veillette A.

Nat Immunol. 2016 Apr;17(4):387-96. doi: 10.1038/ni.3369. Epub 2016 Feb 15.

PMID:
26878112
6.
7.

Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.

Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL.

Immunity. 2012 Jun 29;36(6):1003-16. doi: 10.1016/j.immuni.2012.05.017. Epub 2012 Jun 7.

8.

NK cell regulation by SLAM family receptors and SAP-related adapters.

Veillette A.

Immunol Rev. 2006 Dec;214:22-34. Review.

PMID:
17100873
9.

The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation.

Gu C, Tangye SG, Sun X, Luo Y, Lin Z, Wu J.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14447-52. Epub 2006 Sep 18.

10.

SAP couples Fyn to SLAM immune receptors.

Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ.

Nat Cell Biol. 2003 Feb;5(2):155-60.

PMID:
12545174
12.

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor.

Roncagalli R, Taylor JE, Zhang S, Shi X, Chen R, Cruz-Munoz ME, Yin L, Latour S, Veillette A.

Nat Immunol. 2005 Oct;6(10):1002-10. Epub 2005 Aug 28.

PMID:
16127454
13.

SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.

Simarro M, Lanyi A, Howie D, Poy F, Bruggeman J, Choi M, Sumegi J, Eck MJ, Terhorst C.

Int Immunol. 2004 May;16(5):727-36. Epub 2004 Apr 13.

PMID:
15096483
14.

The adaptor 3BP2 activates CD244-mediated cytotoxicity in PKC- and SAP-dependent mechanisms.

Saborit-Villarroya I, Martinez-Barriocanal A, Oliver-Vila I, Engel P, Sayos J, Martin M.

Mol Immunol. 2008 Jul;45(12):3446-53. doi: 10.1016/j.molimm.2008.03.021. Epub 2008 May 13.

PMID:
18479751
15.

SAP and SLAM expression in anti-CD3 activated lymphocytes correlates with cytotoxic activity.

Mehrle S, Frank S, Schmidt J, Schmidt-Wolf IG, Märten A.

Immunol Cell Biol. 2005 Feb;83(1):33-9.

PMID:
15661039
16.

Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.

Menard L, Cantaert T, Chamberlain N, Tangye SG, Riminton S, Church JA, Klion A, Cunningham-Rundles C, Nichols KE, Meffre E.

J Allergy Clin Immunol. 2014 Apr;133(4):1149-61. doi: 10.1016/j.jaci.2013.10.051. Epub 2013 Dec 25.

17.

Role of SLAM-associated protein in the pathogenesis of autoimmune diseases and immunological disorders.

Furukawa H, Tohma S, Kitazawa H, Komori H, Nose M, Ono M.

Arch Immunol Ther Exp (Warsz). 2010 Feb;58(1):37-44. doi: 10.1007/s00005-009-0060-7. Epub 2010 Jan 5. Review.

PMID:
20049647
18.

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.

Nichols KE, Ma CS, Cannons JL, Schwartzberg PL, Tangye SG.

Immunol Rev. 2005 Feb;203:180-99. Review.

PMID:
15661030
19.

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

Ma CS, Nichols KE, Tangye SG.

Annu Rev Immunol. 2007;25:337-79. Review.

PMID:
17201683
20.

Differential requirement for the SAP-Fyn interaction during NK T cell development and function.

Nunez-Cruz S, Yeo WC, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE.

J Immunol. 2008 Aug 15;181(4):2311-20.

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