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Items: 1 to 20 of 193

1.

Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.

Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV Jr, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB.

Cell Metab. 2012 Jun 6;15(6):873-84. doi: 10.1016/j.cmet.2012.05.002.

2.

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferré P, Foufelle F.

J Clin Invest. 2009 May;119(5):1201-15. doi: 10.1172/JCI37007. Epub 2009 Apr 13.

3.

Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.

Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C.

J Biol Chem. 2004 May 7;279(19):20314-26. Epub 2004 Feb 25.

4.

Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.

Yan F, Wang Q, Lu M, Chen W, Song Y, Jing F, Guan Y, Wang L, Lin Y, Bo T, Zhang J, Wang T, Xin W, Yu C, Guan Q, Zhou X, Gao L, Xu C, Zhao J.

J Hepatol. 2014 Dec;61(6):1358-64. doi: 10.1016/j.jhep.2014.06.037. Epub 2014 Jul 10.

PMID:
25016220
5.

E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.

Tong X, Li P, Zhang D, VanDommelen K, Gupta N, Rui L, Omary MB, Yin L.

J Lipid Res. 2016 Jul;57(7):1219-30. doi: 10.1194/jlr.M067181. Epub 2016 Jun 1.

6.

Clusterin decreases hepatic SREBP-1c expression and lipid accumulation.

Seo HY, Kim MK, Jung YA, Jang BK, Yoo EK, Park KG, Lee IK.

Endocrinology. 2013 May;154(5):1722-30. doi: 10.1210/en.2012-2009. Epub 2013 Mar 20. Erratum in: Endocrinology. 2013 Jun;154(6):2254.

PMID:
23515283
7.

Reversion of steatosis by SREBP-1c antisense oligonucleotide did not improve hepatic insulin action in diet-induced obesity mice.

Vitto MF, Luz G, Luciano TF, Marques SO, Souza DR, Pinho RA, Lira FS, Cintra DE, De Souza CT.

Horm Metab Res. 2012 Nov;44(12):885-90. doi: 10.1055/s-0032-1321819. Epub 2012 Aug 29.

PMID:
22932913
8.

The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression.

Stoeckman AK, Towle HC.

J Biol Chem. 2002 Jul 26;277(30):27029-35. Epub 2002 May 16.

9.

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus.

Shimomura I, Bashmakov Y, Horton JD.

J Biol Chem. 1999 Oct 15;274(42):30028-32.

10.

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.

Matsuzaka T, Shimano H, Yahagi N, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Tomita S, Sekiya M, Hasty A, Nakagawa Y, Sone H, Toyoshima H, Ishibashi S, Osuga J, Yamada N.

Diabetes. 2004 Mar;53(3):560-9.

11.

Hepatic differentiated embryo-chondrocyte-expressed gene 1 (Dec1) inhibits sterol regulatory element-binding protein-1c (Srebp-1c) expression and alleviates fatty liver phenotype.

Shen L, Cui A, Xue Y, Cui Y, Dong X, Gao Y, Yang H, Fang F, Chang Y.

J Biol Chem. 2014 Aug 22;289(34):23332-42. doi: 10.1074/jbc.M113.526343. Epub 2014 Jul 3.

12.
13.

Modulation of hepatic sterol regulatory element-binding protein-1c-mediated gene expression contributes to Salacia oblonga root-elicited improvement of fructose-induced fatty liver in rats.

Liu L, Yang M, Lin X, Li Y, Liu C, Yang Y, Yamahara J, Wang J, Li Y.

J Ethnopharmacol. 2013 Dec 12;150(3):1045-52. doi: 10.1016/j.jep.2013.10.020. Epub 2013 Oct 21.

PMID:
24157375
14.

Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice.

Qin X, Xie X, Fan Y, Tian J, Guan Y, Wang X, Zhu Y, Wang N.

Hepatology. 2008 Aug;48(2):432-41. doi: 10.1002/hep.22334.

PMID:
18627005
15.

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

Yamamoto T, Watanabe K, Inoue N, Nakagawa Y, Ishigaki N, Matsuzaka T, Takeuchi Y, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Yahagi N, Gotoda T, Yamada N, Shimano H.

J Lipid Res. 2010 Jul;51(7):1859-70. doi: 10.1194/jlr.M004234. Epub 2010 Feb 23.

16.

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.

Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.

J Biol Chem. 2002 May 31;277(22):19353-7. Epub 2002 Mar 28.

17.

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

Sajan MP, Standaert ML, Nimal S, Varanasi U, Pastoor T, Mastorides S, Braun U, Leitges M, Farese RV.

J Lipid Res. 2009 Jun;50(6):1133-45. doi: 10.1194/jlr.M800520-JLR200. Epub 2009 Feb 6.

18.

Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion.

Pettinelli P, Del Pozo T, Araya J, Rodrigo R, Araya AV, Smok G, Csendes A, Gutierrez L, Rojas J, Korn O, Maluenda F, Diaz JC, Rencoret G, Braghetto I, Castillo J, Poniachik J, Videla LA.

Biochim Biophys Acta. 2009 Nov;1792(11):1080-6. doi: 10.1016/j.bbadis.2009.08.015. Epub 2009 Sep 4.

19.

Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis.

Zhang YL, Hernandez-Ono A, Siri P, Weisberg S, Conlon D, Graham MJ, Crooke RM, Huang LS, Ginsberg HN.

J Biol Chem. 2006 Dec 8;281(49):37603-15. Epub 2006 Sep 12.

20.

Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins.

Miao J, Haas JT, Manthena P, Wang Y, Zhao E, Vaitheesvaran B, Kurland IJ, Biddinger SB.

J Lipid Res. 2014 Apr;55(4):659-67. doi: 10.1194/jlr.M043711. Epub 2014 Feb 10.

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