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Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.

Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10024-9. doi: 10.1073/pnas.1120755109. Epub 2012 Jun 4. Erratum in: Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18625.


Constitutive MEK1 activation rescues anthrax lethal toxin-induced vascular effects in vivo.

Bolcome RE 3rd, Chan J.

Infect Immun. 2010 Dec;78(12):5043-53. doi: 10.1128/IAI.00604-10. Epub 2010 Sep 20.


Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.

Chauncey KM, Lopez MC, Sidhu G, Szarowicz SE, Baker HV, Quinn C, Southwick FS.

BMC Immunol. 2012 Jul 2;13:33. doi: 10.1186/1471-2172-13-33.


Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice.

Gozes Y, Moayeri M, Wiggins JF, Leppla SH.

Infect Immun. 2006 Feb;74(2):1266-72.


Anthrax lethal toxin has direct and potent inhibitory effects on B cell proliferation and immunoglobulin production.

Fang H, Xu L, Chen TY, Cyr JM, Frucht DM.

J Immunol. 2006 May 15;176(10):6155-61.


Erythropoiesis suppression is associated with anthrax lethal toxin-mediated pathogenic progression.

Chang HH, Wang TP, Chen PK, Lin YY, Liao CH, Lin TK, Chiang YW, Lin WB, Chiang CY, Kau JH, Huang HH, Hsu HL, Liao CY, Sun DS.

PLoS One. 2013 Aug 19;8(8):e71718. doi: 10.1371/journal.pone.0071718. eCollection 2013.


Bacillus anthracis genomic DNA enhances lethal toxin-induced cytotoxicity through TNF-α production.

Jeon JH, Kim YH, Choi MK, Kim KA, Lee HR, Jang J, Kim YR, Chun JH, Eo SK, Kim TS, Rhie GE.

BMC Microbiol. 2014 Dec 4;14:300. doi: 10.1186/s12866-014-0300-9.


Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria.

Sun C, Fang H, Xie T, Auth RD, Patel N, Murray PR, Snoy PJ, Frucht DM.

PLoS One. 2012;7(3):e33583. doi: 10.1371/journal.pone.0033583. Epub 2012 Mar 16.


Anthrax lethal toxin blocks MAPK kinase-dependent IL-2 production in CD4+ T cells.

Fang H, Cordoba-Rodriguez R, Lankford CS, Frucht DM.

J Immunol. 2005 Apr 15;174(8):4966-71.


Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis.

Terra JK, France B, Cote CK, Jenkins A, Bozue JA, Welkos SL, Bhargava R, Ho CL, Mehrabian M, Pan C, Lusis AJ, Davis RC, LeVine SM, Bradley KA.

PLoS Pathog. 2011 Dec;7(12):e1002469. doi: 10.1371/journal.ppat.1002469. Epub 2011 Dec 29.


Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis.

Tuo QH, Zeng H, Stinnett A, Yu H, Aschner JL, Liao DF, Chen JX.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2547-57. doi: 10.1152/ajpheart.01250.2007. Epub 2008 Apr 11.


Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background.

Weigel KJ, Rues L, Doyle EJ, Buchheit CL, Wood JG, Gallagher RJ, Kelly LE, Radel JD, Bradley KA, LeVine SM.

PLoS One. 2012;7(7):e40126. doi: 10.1371/journal.pone.0040126. Epub 2012 Jul 5.


Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.

David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM.

Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L851-62. doi: 10.1152/ajplung.00459.2010. Epub 2011 Mar 18.


Bacillus anthracis: a multi-faceted role for anthrax lethal toxin in thwarting host immune defenses.

Xu L, Frucht DM.

Int J Biochem Cell Biol. 2007;39(1):20-4. Epub 2006 Sep 1.


MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function.

Okugawa S, Moayeri M, Eckhaus MA, Crown D, Miller-Randolph S, Liu S, Akira S, Leppla SH.

Infect Immun. 2011 Jan;79(1):118-24. doi: 10.1128/IAI.00963-10. Epub 2010 Oct 25.


Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability.

Rolando M, Munro P, Stefani C, Auberger P, Flatau G, Lemichez E.

Infect Immun. 2009 Sep;77(9):3596-601. doi: 10.1128/IAI.00186-09. Epub 2009 Jun 22.


The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway.

Thurston G, Daly C.

Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a006550. doi: 10.1101/cshperspect.a006650. Review.


Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells.

Hayes AJ, Huang WQ, Mallah J, Yang D, Lippman ME, Li LY.

Microvasc Res. 1999 Nov;58(3):224-37.


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