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Items: 1 to 20 of 90

1.
2.

Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P.

J Biomol Screen. 2008 Jan;13(1):17-28. doi: 10.1177/1087057107310806.

PMID:
18227223
3.

2D and 3D cell microarrays in pharmacology.

Gidrol X, Fouqué B, Ghenim L, Haguet V, Picollet-D'hahan N, Schaack B.

Curr Opin Pharmacol. 2009 Oct;9(5):664-8. doi: 10.1016/j.coph.2009.05.002. Epub 2009 Jun 10. Review.

PMID:
19520607
4.

A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.

Mathews LA, Keller JM, Goodwin BL, Guha R, Shinn P, Mull R, Thomas CJ, de Kluyver RL, Sayers TJ, Ferrer M.

J Biomol Screen. 2012 Oct;17(9):1231-42. Epub 2012 Aug 27.

PMID:
22927676
5.

Novel trends in high-throughput screening.

Mayr LM, Bojanic D.

Curr Opin Pharmacol. 2009 Oct;9(5):580-8. doi: 10.1016/j.coph.2009.08.004. Epub 2009 Sep 21. Review.

PMID:
19775937
6.

The multicellular tumor spheroid model for high-throughput cancer drug discovery.

LaBarbera DV, Reid BG, Yoo BH.

Expert Opin Drug Discov. 2012 Sep;7(9):819-30. doi: 10.1517/17460441.2012.708334. Epub 2012 Jul 12. Review.

PMID:
22788761
7.

Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei.

Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Ioset JR, Cordeiro-da-Silva A, Freitas-Junior LH.

J Biomol Screen. 2015 Jan;20(1):70-81. doi: 10.1177/1087057114556236. Epub 2014 Oct 23.

PMID:
25342146
8.

Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption.

Mezna M, Wong AC, Ainger M, Scott RW, Hammonds T, Olson MF.

J Biomol Screen. 2012 Apr;17(4):460-8. doi: 10.1177/1087057111430529. Epub 2011 Dec 7.

9.

Validating a firefly luciferase-based high-throughput screening assay for antimalarial drug discovery.

Che P, Cui L, Kutsch O, Cui L, Li Q.

Assay Drug Dev Technol. 2012 Feb;10(1):61-8. doi: 10.1089/adt.2011.0378. Epub 2011 Nov 3.

10.

3D in vitro tissue models and their potential for drug screening.

Kimlin L, Kassis J, Virador V.

Expert Opin Drug Discov. 2013 Dec;8(12):1455-66. doi: 10.1517/17460441.2013.852181. Epub 2013 Oct 22. Review.

PMID:
24144315
11.

Targeting the DNA damage response in oncology: past, present and future perspectives.

Basu B, Yap TA, Molife LR, de Bono JS.

Curr Opin Oncol. 2012 May;24(3):316-24. doi: 10.1097/CCO.0b013e32835280c6. Review.

PMID:
22476188
12.

Apparent activity in high-throughput screening: origins of compound-dependent assay interference.

Thorne N, Auld DS, Inglese J.

Curr Opin Chem Biol. 2010 Jun;14(3):315-24. doi: 10.1016/j.cbpa.2010.03.020. Epub 2010 Apr 22. Review.

13.

Enhancing reproducibility in cancer drug screening: how do we move forward?

Hatzis C, Bedard PL, Birkbak NJ, Beck AH, Aerts HJ, Stem DF, Shi L, Clarke R, Quackenbush J, Haibe-Kains B.

Cancer Res. 2014 Aug 1;74(15):4016-23. doi: 10.1158/0008-5472.CAN-14-0725. Epub 2014 Jul 11. Review. Erratum in: Cancer Res. 2014 Sep 15;74(18):5348. Stern, David F [corrected to Stem, David F].

14.

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5423-8. doi: 10.1073/pnas.1114278109. Epub 2012 Mar 19.

15.

First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass.

Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ, Mumm JS.

Elife. 2015 Jul 28;4. doi: 10.7554/eLife.08261.

16.

Feasibility of implementing cell-based pathway reporter assays in early high-throughput screening assay cascades for antibody drug discovery.

Smith AJ, Hancock MK, Bi K, Andrews J, Harrison P, Vaughan TJ.

J Biomol Screen. 2012 Jul;17(6):713-26. doi: 10.1177/1087057112442962. Epub 2012 Apr 11.

PMID:
22496095
17.

Screening methods for influenza antiviral drug discovery.

Atkins C, Evans CW, White EL, Noah JW.

Expert Opin Drug Discov. 2012 May;7(5):429-38. doi: 10.1517/17460441.2012.674510. Epub 2012 Mar 22. Review.

PMID:
22435452
18.

Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.

Rong J, Pass I, Diaz PW, Ngo TA, Sauer M, Magnuson G, Zeng FY, Hassig CA, Jackson MR, Cosford ND, Matsuzawa S, Reed JC.

J Biomol Screen. 2015 Dec;20(10):1232-45. doi: 10.1177/1087057115600414. Epub 2015 Aug 11.

PMID:
26265713
19.

High-throughput screening normalized to biological response: application to antiviral drug discovery.

Patel DA, Patel AC, Nolan WC, Huang G, Romero AG, Charlton N, Agapov E, Zhang Y, Holtzman MJ.

J Biomol Screen. 2014 Jan;19(1):119-30. doi: 10.1177/1087057113496848. Epub 2013 Jul 16.

20.

Hypothesis testing in high-throughput screening for drug discovery.

Prummer M.

J Biomol Screen. 2012 Apr;17(4):519-29. doi: 10.1177/1087057111431278. Epub 2012 Jan 10.

PMID:
22233646

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