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Items: 1 to 20 of 193


Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein.

Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H.

Inflammation. 2012 Oct;35(5):1611-7. doi: 10.1007/s10753-012-9476-z.


Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.

Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA.

Biochim Biophys Acta. 2006 Oct;1763(10):1051-8. Epub 2006 Aug 5.


Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins.

Fan H, Zingarelli B, Peck OM, Teti G, Tempel GE, Halushka PV, Spicher K, Boulay G, Birnbaumer L, Cook JA.

Am J Physiol Cell Physiol. 2005 Aug;289(2):C293-301. Epub 2005 Mar 23. Erratum in: Am J Physiol Cell Physiol. 2005 Nov;289(5):C1360. Spicher, Karsten [added]; Boulay, Guylain [added]; Birnbaumer, Lutz [added].


Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis.

Fan H, Li P, Zingarelli B, Borg K, Halushka PV, Birnbaumer L, Cook JA.

Biochim Biophys Acta. 2011 Mar;1813(3):466-72. doi: 10.1016/j.bbamcr.2011.01.012. Epub 2011 Jan 19.


Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart.

Waterson RE, Thompson CG, Mabe NW, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR.

Cardiovasc Res. 2011 Jul 1;91(1):45-52. doi: 10.1093/cvr/cvr054. Epub 2011 Feb 23.


Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.

Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA.

Immunology. 2007 Sep;122(1):116-23. Epub 2007 May 2.


RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling.

Liu B, Zhang N, Liu Z, Fu Y, Feng S, Wang S, Cao Y, Li D, Liang D, Li F, Song X, Yang Z.

Mol Cell Biochem. 2013 Jun;378(1-2):183-93. doi: 10.1007/s11010-013-1609-7. Epub 2013 Mar 13.


Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice.

Jung YO, Cho ML, Lee SY, Oh HJ, Park JS, Park MK, Park MJ, Ju JH, Kim SI, Park SH, Kim HY, Min JK.

Immunol Lett. 2009 Apr 27;123(2):138-43. doi: 10.1016/j.imlet.2009.03.004. Epub 2009 Mar 21.


Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice.

Dasu MR, Park S, Devaraj S, Jialal I.

Endocrinology. 2009 Aug;150(8):3457-64. doi: 10.1210/en.2008-1757. Epub 2009 Apr 23.


Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.

Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R.

Anesth Analg. 2009 Nov;109(5):1500-5. doi: 10.1213/ANE.0b013e3181ba7815.


Gαi2 signaling: friend or foe in cardiac injury and heart failure?

Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR.

Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):443-53. doi: 10.1007/s00210-011-0705-z. Epub 2012 Mar 14.


PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages.

Cabanski M, Steinmüller M, Marsh LM, Surdziel E, Seeger W, Lohmeyer J.

Am J Respir Cell Mol Biol. 2008 Jan;38(1):26-31. Epub 2007 Aug 9.


Protective effects of Sparstolonin B, a selective TLR2 and TLR4 antagonist, on mouse endotoxin shock.

Liang Q, Dong S, Lei L, Liu J, Zhang J, Li J, Duan J, Fan D.

Cytokine. 2015 Oct;75(2):302-9. doi: 10.1016/j.cyto.2014.12.003. Epub 2015 Jan 5.


Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR.

Diabetes. 2008 Jan;57(1):77-85. Epub 2007 Oct 10.


Heterotrimeric Gi/Go proteins modulate endothelial TLR signaling independent of the MyD88-dependent pathway.

Dauphinee SM, Voelcker V, Tebaykina Z, Wong F, Karsan A.

Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2246-53. doi: 10.1152/ajpheart.01194.2010. Epub 2011 Sep 23.


Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide.

Matera G, Muto V, Vinci M, Zicca E, Abdollahi-Roodsaz S, van de Veerdonk FL, Kullberg BJ, Liberto MC, van der Meer JW, Focà A, Netea MG, Joosten LA.

Clin Vaccine Immunol. 2009 Dec;16(12):1804-9. doi: 10.1128/CVI.00310-09. Epub 2009 Oct 14.


Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.

Means TK, Jones BW, Schromm AB, Shurtleff BA, Smith JA, Keane J, Golenbock DT, Vogel SN, Fenton MJ.

J Immunol. 2001 Mar 15;166(6):4074-82.

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