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Items: 1 to 20 of 75

1.

Efficiency and specificity in microRNA biogenesis.

Barad O, Mann M, Chapnik E, Shenoy A, Blelloch R, Barkai N, Hornstein E.

Nat Struct Mol Biol. 2012 May 13;19(6):650-2. doi: 10.1038/nsmb.2293.

2.

Post-transcriptional control of DGCR8 expression by the Microprocessor.

Triboulet R, Chang HM, Lapierre RJ, Gregory RI.

RNA. 2009 Jun;15(6):1005-11. doi: 10.1261/rna.1591709. Epub 2009 Apr 21.

3.

The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.

Roth BM, Ishimaru D, Hennig M.

J Biol Chem. 2013 Sep 13;288(37):26785-99. doi: 10.1074/jbc.M112.446880. Epub 2013 Jul 26.

4.

A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.

Herbert KM, Sarkar SK, Mills M, Delgado De la Herran HC, Neuman KC, Steitz JA.

RNA. 2016 Feb;22(2):175-83. doi: 10.1261/rna.054684.115. Epub 2015 Dec 18.

5.

Autoregulatory mechanisms controlling the Microprocessor.

Triboulet R, Gregory RI.

Adv Exp Med Biol. 2010;700:56-66. Review.

PMID:
21627030
6.

Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes.

Bellemer C, Bortolin-Cavaillé ML, Schmidt U, Jensen SM, Kjems J, Bertrand E, Cavaillé J.

J Cell Sci. 2012 Jun 1;125(Pt 11):2709-20. doi: 10.1242/jcs.100354. Epub 2012 Mar 5.

7.

The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.

Tu CC, Zhong Y, Nguyen L, Tsai A, Sridevi P, Tarn WY, Wang JY.

Sci Signal. 2015 Jun 30;8(383):ra64. doi: 10.1126/scisignal.aaa4468.

8.

A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA.

Burke JM, Kelenis DP, Kincaid RP, Sullivan CS.

RNA. 2014 Jul;20(7):1068-77. doi: 10.1261/rna.044537.114. Epub 2014 May 22.

9.

Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8.

Barr I, Guo F.

Methods Mol Biol. 2014;1095:73-86. doi: 10.1007/978-1-62703-703-7_5.

10.

Posttranscriptional crossregulation between Drosha and DGCR8.

Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, Yeom KH, Yang WY, Haussler D, Blelloch R, Kim VN.

Cell. 2009 Jan 9;136(1):75-84. doi: 10.1016/j.cell.2008.10.053.

11.

BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex.

Kawai S, Amano A.

J Cell Biol. 2012 Apr 16;197(2):201-8. doi: 10.1083/jcb.201110008. Epub 2012 Apr 9.

12.

Autoregulatory mechanisms controlling the microprocessor.

Triboulet R, Gregory RI.

Adv Exp Med Biol. 2011;700:56-66.

PMID:
21755473
13.

Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.

Shenoy A, Blelloch R.

PLoS One. 2009 Sep 11;4(9):e6971. doi: 10.1371/journal.pone.0006971.

14.

SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.

Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J.

Nucleic Acids Res. 2015 Sep 18;43(16):7945-60. doi: 10.1093/nar/gkv741. Epub 2015 Jul 21.

15.

Cellular functions of the microprocessor.

Macias S, Cordiner RA, Cáceres JF.

Biochem Soc Trans. 2013 Aug;41(4):838-43. doi: 10.1042/BST20130011. Review.

PMID:
23863141
16.

Nucleolin protein interacts with microprocessor complex to affect biogenesis of microRNAs 15a and 16.

Pickering BF, Yu D, Van Dyke MW.

J Biol Chem. 2011 Dec 23;286(51):44095-103. doi: 10.1074/jbc.M111.265439. Epub 2011 Nov 2.

17.

Processing of microRNA primary transcripts requires heme in mammalian cells.

Weitz SH, Gong M, Barr I, Weiss S, Guo F.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1861-6. doi: 10.1073/pnas.1309915111. Epub 2014 Jan 21.

18.

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.

Macias S, Plass M, Stajuda A, Michlewski G, Eyras E, Cáceres JF.

Nat Struct Mol Biol. 2012 Aug;19(8):760-6. doi: 10.1038/nsmb.2344. Epub 2012 Jul 15.

19.

N6-methyladenosine marks primary microRNAs for processing.

Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF.

Nature. 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281. Epub 2015 Mar 18.

20.

Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site.

Ma H, Wu Y, Choi JG, Wu H.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20687-92. doi: 10.1073/pnas.1311639110. Epub 2013 Dec 2.

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