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Items: 1 to 20 of 199

1.

Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor.

Zhang C, de Silva S, Wang JH, Wu L.

PLoS One. 2012;7(5):e37477. doi: 10.1371/journal.pone.0037477. Epub 2012 May 4.

2.

Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.

Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M.

PLoS Pathog. 2013;9(7):e1003496. doi: 10.1371/journal.ppat.1003496. Epub 2013 Jul 18.

3.

Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins.

Wei W, Guo H, Gao Q, Markham R, Yu XF.

J Virol. 2014 Jan;88(1):583-91. doi: 10.1128/JVI.02866-13. Epub 2013 Oct 30.

4.

Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1.

Li J, Xu F, Hu S, Zhou J, Mei S, Zhao X, Cen S, Jin Q, Liang C, Guo F.

Biochem J. 2015 Jun 1;468(2):303-13. doi: 10.1042/BJ20141331.

PMID:
25791246
5.

Degradation of SAMHD1 by Vpx Is Independent of Uncoating.

Jáuregui P, Logue EC, Schultz ML, Fung S, Landau NR.

J Virol. 2015 May;89(10):5701-13. doi: 10.1128/JVI.03575-14. Epub 2015 Mar 11.

6.

Characterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentiviruses.

Kobayashi T, Takeuchi JS, Ren F, Matsuda K, Sato K, Kimura Y, Misawa N, Yoshikawa R, Nakano Y, Yamada E, Tanaka H, Hirsch VM, Koyanagi Y.

Sci Rep. 2014 Jul 2;4:5529. doi: 10.1038/srep05529.

7.

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM, Skowronski J.

J Biol Chem. 2012 Apr 6;287(15):12550-8. doi: 10.1074/jbc.M112.340711. Epub 2012 Feb 23.

8.

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.

Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Münch J, Snoeck J, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A, Benkirane M.

Cell Host Microbe. 2012 Feb 16;11(2):205-17. doi: 10.1016/j.chom.2012.01.007. Epub 2012 Feb 1.

9.

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.

Brandariz-Nuñez A, Valle-Casuso JC, White TE, Laguette N, Benkirane M, Brojatsch J, Diaz-Griffero F.

Retrovirology. 2012 Jun 12;9:49. doi: 10.1186/1742-4690-9-49.

10.

The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.

Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M.

Cell Host Microbe. 2012 Feb 16;11(2):194-204. doi: 10.1016/j.chom.2012.01.004. Epub 2012 Jan 26.

11.

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22.

12.

Down-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz.

Nakano Y, Matsuda K, Yoshikawa R, Yamada E, Misawa N, Hirsch VM, Koyanagi Y, Sato K.

J Gen Virol. 2015 Sep;96(9):2867-77. doi: 10.1099/vir.0.000207. Epub 2015 Jun 3.

13.

HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.

DeLucia M, Mehrens J, Wu Y, Ahn J.

J Biol Chem. 2013 Jun 28;288(26):19116-26. doi: 10.1074/jbc.M113.469007. Epub 2013 May 15.

14.

Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile α Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors.

Wu Y, Koharudin LM, Mehrens J, DeLucia M, Byeon CH, Byeon IJ, Calero G, Ahn J, Gronenborn AM.

J Biol Chem. 2015 Jul 17;290(29):17935-45. doi: 10.1074/jbc.M115.665513. Epub 2015 Jun 4.

15.

A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.

Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W, Yu XF.

Cell Microbiol. 2012 Nov;14(11):1745-56. doi: 10.1111/j.1462-5822.2012.01835.x. Epub 2012 Aug 9.

PMID:
22776683
16.

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.

Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O, Benkirane M.

Nature. 2011 May 25;474(7353):654-7. doi: 10.1038/nature10117.

17.

Natural infection of a household pet red-capped mangabey (Cercocebus torquatus torquatus) with a new simian immunodeficiency virus.

Georges-Courbot MC, Lu CY, Makuwa M, Telfer P, Onanga R, Dubreuil G, Chen Z, Smith SM, Georges A, Gao F, Hahn BH, Marx PA.

J Virol. 1998 Jan;72(1):600-8.

18.

Transactivation is a conserved function among primate lentivirus Vpr proteins but is not shared by Vpx.

Philippon V, Matsuda Z, Essex M.

J Hum Virol. 1999 May-Jun;2(3):167-74.

PMID:
10413368
19.
20.

Gene loss and adaptation to hominids underlie the ancient origin of HIV-1.

Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.

Cell Host Microbe. 2013 Jul 17;14(1):85-92. doi: 10.1016/j.chom.2013.06.002.

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