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TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex.

Thillainadesan G, Chitilian JM, Isovic M, Ablack JN, Mymryk JS, Tini M, Torchia J.

Mol Cell. 2012 Jun 8;46(5):636-49. doi: 10.1016/j.molcel.2012.03.027. Epub 2012 May 3.


Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex.

Thillainadesan G, Isovic M, Loney E, Andrews J, Tini M, Torchia J.

Mol Cell Biol. 2008 Oct;28(19):6066-77. doi: 10.1128/MCB.00246-08. Epub 2008 Jul 14.


Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.

Peng B, Fleming JB, Breslin T, Grau AM, Fojioka S, Abbruzzese JL, Evans DB, Ayers D, Wathen K, Wu T, Robertson KD, Chiao PJ.

Clin Cancer Res. 2002 Nov;8(11):3628-38.


E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.

Li JM, Hu PP, Shen X, Yu Y, Wang XF.

Proc Natl Acad Sci U S A. 1997 May 13;94(10):4948-53.


Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site.

Li JM, Nichols MA, Chandrasekharan S, Xiong Y, Wang XF.

J Biol Chem. 1995 Nov 10;270(45):26750-3.


Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression.

Quesnel B, Guillerm G, Vereecque R, Wattel E, Preudhomme C, Bauters F, Vanrumbeke M, Fenaux P.

Blood. 1998 Apr 15;91(8):2985-90.


Ectopic expression of Cdk6 circumvents transforming growth factor-beta mediated growth inhibition.

Zhang F, Taipale M, Heiskanen A, Laiho M.

Oncogene. 2001 Sep 13;20(41):5888-96.


The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.

Datto MB, Hu PP, Kowalik TF, Yingling J, Wang XF.

Mol Cell Biol. 1997 Apr;17(4):2030-7.


Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition.

Lakshmikuttyamma A, Scott SA, DeCoteau JF, Geyer CR.

Oncogene. 2010 Jan 28;29(4):576-88. doi: 10.1038/onc.2009.361. Epub 2009 Nov 2.


Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation.

Schmidt M, Koller R, Haviernik P, Bies J, Maciag K, Wolff L.

Oncogene. 2001 Sep 27;20(43):6205-14.


[Phenylhexyl isothiocyanate induces gene p15 demethylation by down-regulating DNA methyltransferases in Molt-4 cells].

Jiang SH, Ma XD, Huang YQ, Xu YL, Zheng RJ.

Yao Xue Xue Bao. 2009 Apr;44(4):350-4. Chinese.


Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia.

Scott SA, Kimura T, Dong WF, Ichinohasama R, Bergen S, Kerviche A, Sheridan D, DeCoteau JF.

Leuk Res. 2004 Dec;28(12):1293-301.


Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene.

Hitomi T, Matsuzaki Y, Yasuda S, Kawanaka M, Yogosawa S, Koyama M, Tantin D, Sakai T.

FEBS Lett. 2007 Mar 20;581(6):1087-92. Epub 2007 Feb 14.


Id2 suppression of p15 counters TGF-beta-mediated growth inhibition of melanoma cells.

Schlegel NC, Eichhoff OM, Hemmi S, Werner S, Dummer R, Hoek KS.

Pigment Cell Melanoma Res. 2009 Aug;22(4):445-53. doi: 10.1111/j.1755-148X.2009.00571.x. Epub 2009 Apr 24.


Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor.

Xu W, Angelis K, Danielpour D, Haddad MM, Bischof O, Campisi J, Stavnezer E, Medrano EE.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5924-9.

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