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Items: 1 to 20 of 94

1.

Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).

Tweats D, Bourdin Trunz B, Torreele E.

Mutagenesis. 2012 Sep;27(5):523-32. doi: 10.1093/mutage/ges015. Epub 2012 Apr 26.

PMID:
22539226
2.

Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.

Torreele E, Bourdin Trunz B, Tweats D, Kaiser M, Brun R, Mazué G, Bray MA, Pécoul B.

PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. doi: 10.1371/journal.pntd.0000923.

3.

1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.

Trunz BB, Jędrysiak R, Tweats D, Brun R, Kaiser M, Suwiński J, Torreele E.

Eur J Med Chem. 2011 May;46(5):1524-35. doi: 10.1016/j.ejmech.2011.01.071. Epub 2011 Feb 26.

PMID:
21353728
4.

Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness.

Kaiser M, Bray MA, Cal M, Bourdin Trunz B, Torreele E, Brun R.

Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8. doi: 10.1128/AAC.00246-11. Epub 2011 Sep 12.

5.

Fexinidazole: a potential new drug candidate for Chagas disease.

Bahia MT, de Andrade IM, Martins TA, do Nascimento ÁF, Diniz Lde F, Caldas IS, Talvani A, Trunz BB, Torreele E, Ribeiro I.

PLoS Negl Trop Dis. 2012;6(11):e1870. doi: 10.1371/journal.pntd.0001870. Epub 2012 Nov 1.

6.

Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies.

Tarral A, Blesson S, Mordt OV, Torreele E, Sassella D, Bray MA, Hovsepian L, Evène E, Gualano V, Felices M, Strub-Wourgaft N.

Clin Pharmacokinet. 2014 Jun;53(6):565-80. doi: 10.1007/s40262-014-0136-3.

7.

Development of novel drugs for human African trypanosomiasis.

Brun R, Don R, Jacobs RT, Wang MZ, Barrett MP.

Future Microbiol. 2011 Jun;6(6):677-91. doi: 10.2217/fmb.11.44. Review.

8.

Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

Wilkinson SR, Bot C, Kelly JM, Hall BS.

Curr Top Med Chem. 2011;11(16):2072-84. Review.

PMID:
21619510
9.

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Wyllie S, Patterson S, Stojanovski L, Simeons FR, Norval S, Kime R, Read KD, Fairlamb AH.

Sci Transl Med. 2012 Feb 1;4(119):119re1. doi: 10.1126/scitranslmed.3003326.

10.
11.

In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N'-diacetyl metabolites.

Garrigue JL, Ballantyne M, Kumaravel T, Lloyd M, Nohynek GJ, Kirkland D, Toutain H.

Mutat Res. 2006 Sep 19;608(1):58-71. Epub 2006 Jun 30.

PMID:
16807077
12.

An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one].

Nohynek GJ, Kirkland D, Marzin D, Toutain H, Leclerc-Ribaud C, Jinnai H.

Food Chem Toxicol. 2004 Jan;42(1):93-105.

PMID:
14630133
14.

A DBS method for quantitation of the new oral trypanocidal drug fexinidazole and its active metabolites.

Filali-Ansary A, Augé C, Abgrall A, Souchaud M, Pellissier F, Mordt OV, Blesson S, Sanderink GJ.

Bioanalysis. 2016 Oct;8(19):2045-63. doi: 10.4155/bio-2016-0110. Epub 2016 Sep 9.

PMID:
27611920
15.

Genotoxicity assessment of S-equol in bacterial mutation, chromosomal aberration, and rodent bone marrow micronucleus tests.

Schwen R, Jackson R, Proudlock R.

Food Chem Toxicol. 2010 Dec;48(12):3481-5. doi: 10.1016/j.fct.2010.09.027. Epub 2010 Sep 27.

PMID:
20875837
16.

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

Kirkland D, Pfuhler S, Tweats D, Aardema M, Corvi R, Darroudi F, Elhajouji A, Glatt H, Hastwell P, Hayashi M, Kasper P, Kirchner S, Lynch A, Marzin D, Maurici D, Meunier JR, Müller L, Nohynek G, Parry J, Parry E, Thybaud V, Tice R, van Benthem J, Vanparys P, White P.

Mutat Res. 2007 Mar 30;628(1):31-55. Epub 2007 Jan 13.

PMID:
17293159
18.

In vitro and in vivo chromosomal aberrations induced by megazol.

Nesslany F, Brugier S, Mouriès MA, Le Curieux F, Marzin D.

Mutat Res. 2004 Jun 13;560(2):147-58.

PMID:
15157652
19.

Recent Updates on Development of Drug Molecules for Human African Trypanosomiasis.

Singh Grewal A, Pandita D, Bhardwaj S, Lather V.

Curr Top Med Chem. 2016;16(20):2245-65. Review.

PMID:
27072715
20.

Mutagenic and clastogenic activity of the chloro-nitroimidazole radiosensitizer P40 in vitro and in vivo.

Konopacka M, Wideł M, Grzybowska E, Suwiński J.

Pol J Pharmacol Pharm. 1992 May-Jun;44(3):299-306.

PMID:
1470567

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