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Items: 1 to 20 of 79

1.

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.

Yoshimi M, Goyama S, Kawazu M, Nakagawa M, Ichikawa M, Imai Y, Kumano K, Asai T, Mulloy JC, Kraft AS, Takahashi T, Shirafuji N, Kurokawa M.

Eur J Immunol. 2012 Apr;42(4):1044-50. doi: 10.1002/eji.201040746.

2.

Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation.

Tachibana M, Tezuka C, Muroi S, Nishimoto S, Katsumoto T, Nakajima A, Kitabayashi I, Taniuchi I.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):536-42. doi: 10.1016/j.bbrc.2008.01.124. Epub 2008 Feb 6.

PMID:
18261462
3.

A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation.

Dowdy CR, Frederick D, Zaidi SK, Colby JL, Lian JB, van Wijnen AJ, Gerstein RM, Stein JL, Stein GS.

Exp Hematol. 2013 Nov;41(11):980-991.e1. doi: 10.1016/j.exphem.2013.06.006. Epub 2013 Jun 30.

4.

Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.

Tornack J, Seiler K, Grützkau A, Grün JR, Onodera M, Melchers F, Tsuneto M.

PLoS One. 2013 Jul 29;8(7):e70116. doi: 10.1371/journal.pone.0070116. Print 2013.

5.

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.

Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng GS, Steen H, Cantor AB.

Genes Dev. 2012 Jul 15;26(14):1587-601. doi: 10.1101/gad.192054.112. Epub 2012 Jul 3.

6.

Regulation of RUNX1/AML1 during the G2/M transition.

Wang S, Zhang Y, Soosairajah J, Kraft AS.

Leuk Res. 2007 Jun;31(6):839-51. Epub 2006 Oct 4.

PMID:
17023045
7.

Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.

Mizutani S, Yoshida T, Zhao X, Nimer SD, Taniwaki M, Okuda T.

Br J Haematol. 2015 Sep;170(6):859-73. doi: 10.1111/bjh.13499. Epub 2015 May 26.

8.

RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.

Draper JE, Sroczynska P, Tsoulaki O, Leong HS, Fadlullah MZ, Miller C, Kouskoff V, Lacaud G.

PLoS Genet. 2016 Jan 25;12(1):e1005814. doi: 10.1371/journal.pgen.1005814. eCollection 2016 Jan. Erratum in: PLoS Genet. 2016 May;12(5):e1006084.

9.

Multifunctional reversible knockout/reporter system enabling fully functional reconstitution of the AML1/Runx1 locus and rescue of hematopoiesis.

Samokhvalov IM, Thomson AM, Lalancette C, Liakhovitskaia A, Ure J, Medvinsky A.

Genesis. 2006 Mar;44(3):115-21.

PMID:
16496309
10.

RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation.

Cammenga J, Niebuhr B, Horn S, Bergholz U, Putz G, Buchholz F, Löhler J, Stocking C.

Cancer Res. 2007 Jan 15;67(2):537-45.

11.

Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis.

Pozner A, Lotem J, Xiao C, Goldenberg D, Brenner O, Negreanu V, Levanon D, Groner Y.

BMC Dev Biol. 2007 Jul 12;7:84.

12.

Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.

Guo H, Friedman AD.

J Biol Chem. 2011 Jan 7;286(1):208-15. doi: 10.1074/jbc.M110.149013. Epub 2010 Nov 8.

13.

Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis.

Kalev-Zylinska ML, Horsfield JA, Flores MV, Postlethwait JH, Vitas MR, Baas AM, Crosier PS, Crosier KE.

Development. 2002 Apr;129(8):2015-30.

14.

Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.

Bluteau D, Gilles L, Hilpert M, Antony-Debré I, James C, Debili N, Camara-Clayette V, Wagner-Ballon O, Cordette-Lagarde V, Robert T, Ripoche H, Gonin P, Swierczek S, Prchal J, Vainchenker W, Favier R, Raslova H.

Blood. 2011 Dec 8;118(24):6310-20. doi: 10.1182/blood-2010-12-325555. Epub 2011 Jul 1.

15.

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis.

Sroczynska P, Lancrin C, Kouskoff V, Lacaud G.

Blood. 2009 Dec 17;114(26):5279-89. doi: 10.1182/blood-2009-05-222307. Epub 2009 Oct 26.

16.
17.

A role for RUNX1 in hematopoiesis and myeloid leukemia.

Ichikawa M, Yoshimi A, Nakagawa M, Nishimoto N, Watanabe-Okochi N, Kurokawa M.

Int J Hematol. 2013 Jun;97(6):726-34. doi: 10.1007/s12185-013-1347-3. Epub 2013 Apr 24. Review.

PMID:
23613270
18.

A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model.

Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Z, Okuda T, Oda H, Tsuji K, Honda H.

Dev Biol. 2010 Sep 15;345(2):226-36. doi: 10.1016/j.ydbio.2010.07.015. Epub 2010 Jul 18.

19.

DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo.

Webber BR, Iacovino M, Choi SH, Tolar J, Kyba M, Blazar BR.

Blood. 2013 Oct 24;122(17):2978-86. doi: 10.1182/blood-2013-03-489369. Epub 2013 Sep 12.

20.

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.

Bee T, Swiers G, Muroi S, Pozner A, Nottingham W, Santos AC, Li PS, Taniuchi I, de Bruijn MF.

Blood. 2010 Apr 15;115(15):3042-50. doi: 10.1182/blood-2009-08-238626. Epub 2010 Feb 4.

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