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Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication.

Parussini F, Tang Q, Moin SM, Mital J, Urban S, Ward GE.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7463-8. doi: 10.1073/pnas.1114661109. Epub 2012 Apr 20.


Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail.

Krishnamurthy S, Deng B, Del Rio R, Buchholz KR, Treeck M, Urban S, Boothroyd J, Lam YW, Ward GE.

MBio. 2016 Sep 13;7(5). pii: e00754-16. doi: 10.1128/mBio.00754-16.


Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.

Howell SA, Hackett F, Jongco AM, Withers-Martinez C, Kim K, Carruthers VB, Blackman MJ.

Mol Microbiol. 2005 Sep;57(5):1342-56.


Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode.

Santos JM, Ferguson DJ, Blackman MJ, Soldati-Favre D.

Science. 2011 Jan 28;331(6016):473-7. doi: 10.1126/science.1199284. Epub 2010 Dec 23.


Toxoplasma gondii homologue of plasmodium apical membrane antigen 1 is involved in invasion of host cells.

Hehl AB, Lekutis C, Grigg ME, Bradley PJ, Dubremetz JF, Ortega-Barria E, Boothroyd JC.

Infect Immun. 2000 Dec;68(12):7078-86.


Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasites.

Zhang H, Compaore MK, Lee EG, Liao M, Zhang G, Sugimoto C, Fujisaki K, Nishikawa Y, Xuan X.

Mol Biochem Parasitol. 2007 Feb;151(2):205-12. Epub 2006 Nov 30.


Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii.

Buguliskis JS, Brossier F, Shuman J, Sibley LD.

PLoS Pathog. 2010 Apr 22;6(4):e1000858. doi: 10.1371/journal.ppat.1000858.


The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites.

Lamarque M, Besteiro S, Papoin J, Roques M, Vulliez-Le Normand B, Morlon-Guyot J, Dubremetz JF, Fauquenoy S, Tomavo S, Faber BW, Kocken CH, Thomas AW, Boulanger MJ, Bentley GA, Lebrun M.

PLoS Pathog. 2011 Feb 10;7(2):e1001276. doi: 10.1371/journal.ppat.1001276.


An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding Selectivity.

Parker ML, Boulanger MJ.

PLoS One. 2015 May 8;10(5):e0126206. doi: 10.1371/journal.pone.0126206. eCollection 2015.


The C-terminus of Toxoplasma RON2 provides the crucial link between AMA1 and the host-associated invasion complex.

Tyler JS, Boothroyd JC.

PLoS Pathog. 2011 Feb 10;7(2):e1001282. doi: 10.1371/journal.ppat.1001282.


Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.

Tonkin ML, Roques M, Lamarque MH, Pugnière M, Douguet D, Crawford J, Lebrun M, Boulanger MJ.

Science. 2011 Jul 22;333(6041):463-7. doi: 10.1126/science.1204988.


Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii.

Opitz C, Di Cristina M, Reiss M, Ruppert T, Crisanti A, Soldati D.

EMBO J. 2002 Apr 2;21(7):1577-85.


Focus on the ringleader: the role of AMA1 in apicomplexan invasion and replication.

Tyler JS, Treeck M, Boothroyd JC.

Trends Parasitol. 2011 Sep;27(9):410-20. doi: 10.1016/ Epub 2011 Jun 12. Review.


Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii.

Crawford J, Tonkin ML, Grujic O, Boulanger MJ.

J Biol Chem. 2010 May 14;285(20):15644-52. doi: 10.1074/jbc.M109.092619. Epub 2010 Mar 19.


Functional analysis of rhomboid proteases during Toxoplasma invasion.

Shen B, Buguliskis JS, Lee TD, Sibley LD.

MBio. 2014 Oct 21;5(5):e01795-14. doi: 10.1128/mBio.01795-14.


Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion.

Besteiro S, Michelin A, Poncet J, Dubremetz JF, Lebrun M.

PLoS Pathog. 2009 Feb;5(2):e1000309. doi: 10.1371/journal.ppat.1000309. Epub 2009 Feb 27.


Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion.

Bargieri DY, Andenmatten N, Lagal V, Thiberge S, Whitelaw JA, Tardieux I, Meissner M, Ménard R.

Nat Commun. 2013;4:2552. doi: 10.1038/ncomms3552.


Host cell binding of GRA10, a novel, constitutively secreted dense granular protein from Toxoplasma gondii.

Ahn HJ, Kim S, Nam HW.

Biochem Biophys Res Commun. 2005 Jun 3;331(2):614-20.


C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells.

Brossier F, Jewett TJ, Lovett JL, Sibley LD.

J Biol Chem. 2003 Feb 21;278(8):6229-34. Epub 2002 Dec 5.

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