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Items: 1 to 20 of 140

1.

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.

Philbin VJ, Dowling DJ, Gallington LC, Cortés G, Tan Z, Suter EE, Chi KW, Shuckett A, Stoler-Barak L, Tomai M, Miller RL, Mansfield K, Levy O.

J Allergy Clin Immunol. 2012 Jul;130(1):195-204.e9. doi: 10.1016/j.jaci.2012.02.042. Epub 2012 Apr 21.

2.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O.

PLoS One. 2015 Aug 14;10(8):e0134640. doi: 10.1371/journal.pone.0134640. eCollection 2015.

3.

The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O.

PLoS One. 2013;8(3):e58164. doi: 10.1371/journal.pone.0058164. Epub 2013 Mar 4.

4.

Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells.

Levy O, Suter EE, Miller RL, Wessels MR.

Blood. 2006 Aug 15;108(4):1284-90. Epub 2006 Apr 25.

5.
6.

TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells.

Hurst J, Prinz N, Lorenz M, Bauer S, Chapman J, Lackner KJ, von Landenberg P.

Immunobiology. 2009;214(8):683-91. doi: 10.1016/j.imbio.2008.12.003. Epub 2009 Feb 26.

PMID:
19249118
7.

IL-4 blocks TH1-polarizing/inflammatory cytokine gene expression during monocyte-derived dendritic cell differentiation through histone hypoacetylation.

López-Bravo M, Minguito de la Escalera M, Domínguez PM, González-Cintado L, del Fresno C, Martín P, Martínez del Hoyo G, Ardavín C.

J Allergy Clin Immunol. 2013 Dec;132(6):1409-19. doi: 10.1016/j.jaci.2013.08.039. Epub 2013 Oct 17.

PMID:
24139608
8.

Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells.

Lemoine S, Jaron B, Tabka S, Ettreiki C, Deriaud E, Zhivaki D, Le Ray C, Launay O, Majlessi L, Tissieres P, Leclerc C, Lo-Man R.

J Allergy Clin Immunol. 2015 Nov;136(5):1355-68.e1-15. doi: 10.1016/j.jaci.2015.02.030. Epub 2015 Apr 10.

PMID:
25865351
9.

Zymosan Induces Immune Responses Comparable with Those of Adults in Monocytes, Dendritic Cells, and Monocyte-Derived Dendritic Cells from Cord Blood.

Nohmi K, Tokuhara D, Tachibana D, Saito M, Sakashita Y, Nakano A, Terada H, Katayama H, Koyama M, Shintaku H.

J Pediatr. 2015 Jul;167(1):155-62.e1-2. doi: 10.1016/j.jpeds.2015.03.035. Epub 2015 May 7.

PMID:
25957979
10.

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.

Dowling DJ, Scott EA, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninković J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell JA, Levy O.

J Allergy Clin Immunol. 2017 Mar 14. pii: S0091-6749(17)30242-7. doi: 10.1016/j.jaci.2016.12.985. [Epub ahead of print]

11.

Combined Toll-like receptor agonists synergistically increase production of inflammatory cytokines in human neonatal dendritic cells.

Krumbiegel D, Zepp F, Meyer CU.

Hum Immunol. 2007 Oct;68(10):813-22. Epub 2007 Aug 29.

PMID:
17961769
12.

Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.

van Haren SD, Dowling DJ, Foppen W, Christensen D, Andersen P, Reed SG, Hershberg RM, Baden LR, Levy O.

J Immunol. 2016 Dec 1;197(11):4413-4424. Epub 2016 Oct 28.

PMID:
27793997
13.

Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells.

Lombardi V, Van Overtvelt L, Horiot S, Moingeon P.

J Immunol. 2009 Mar 15;182(6):3372-9. doi: 10.4049/jimmunol.0801969.

14.

TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity.

Du J, Wu Z, Ren S, Wei Y, Gao M, Randolph GJ, Qu C.

Vaccine. 2010 Aug 31;28(38):6273-81. doi: 10.1016/j.vaccine.2010.06.117. Epub 2010 Jul 15.

15.

Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X, Tomai MA, Alkan SS, Vasilakos JP.

J Immunol. 2005 Feb 1;174(3):1259-68.

16.

Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity.

Dietsch GN, Lu H, Yang Y, Morishima C, Chow LQ, Disis ML, Hershberg RM.

PLoS One. 2016 Feb 29;11(2):e0148764. doi: 10.1371/journal.pone.0148764. eCollection 2016.

17.

Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.

Koopman G, Beenhakker N, Burm S, Bouwhuis O, Bajramovic J, Sommandas V, Mudde G, Mooij P, 't Hart BA, Bogers WM.

Clin Exp Immunol. 2013 Oct;174(1):161-71. doi: 10.1111/cei.12155.

18.

Temporal interleukin-1beta secretion from primary human peripheral blood monocytes by P2X7-independent and P2X7-dependent mechanisms.

Ward JR, West PW, Ariaans MP, Parker LC, Francis SE, Crossman DC, Sabroe I, Wilson HL.

J Biol Chem. 2010 Jul 23;285(30):23147-58. doi: 10.1074/jbc.M109.072793. Epub 2010 May 21.

19.

Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075.

Spranger S, Javorovic M, Bürdek M, Wilde S, Mosetter B, Tippmer S, Bigalke I, Geiger C, Schendel DJ, Frankenberger B.

J Immunol. 2010 Jul 1;185(1):738-47. doi: 10.4049/jimmunol.1000060. Epub 2010 May 28.

20.

Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants.

Burl S, Townend J, Njie-Jobe J, Cox M, Adetifa UJ, Touray E, Philbin VJ, Mancuso C, Kampmann B, Whittle H, Jaye A, Flanagan KL, Levy O.

PLoS One. 2011 Apr 13;6(4):e18185. doi: 10.1371/journal.pone.0018185.

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