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Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer.

Dusek RL, Bascom JL, Vogel H, Baron S, Borowsky AD, Bissell MJ, Attardi LD.

Breast Cancer Res. 2012 Apr 20;14(2):R65.


Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.

Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian BC, Attardi LD.

PLoS Genet. 2010 Oct 21;6(10):e1001168. doi: 10.1371/journal.pgen.1001168.


Perp is a p63-regulated gene essential for epithelial integrity.

Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD.

Cell. 2005 Mar 25;120(6):843-56.


A new Perp in the lineup: linking p63 and desmosomal adhesion.

Ihrie RA, Attardi LD.

Cell Cycle. 2005 Jul;4(7):873-6.


p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis.

Yallowitz AR, Alexandrova EM, Talos F, Xu S, Marchenko ND, Moll UM.

Cell Death Differ. 2014 Apr;21(4):645-54. doi: 10.1038/cdd.2013.199.


Mice lacking the p53/p63 target gene Perp are resistant to papilloma development.

Marques MR, Horner JS, Ihrie RA, Bronson RT, Attardi LD.

Cancer Res. 2005 Aug 1;65(15):6551-6.


Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

Cheung AM, Elia A, Tsao MS, Done S, Wagner KU, Hennighausen L, Hakem R, Mak TW.

Cancer Res. 2004 Mar 15;64(6):1959-65.


Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors.

Li H, Cherukuri P, Li N, Cowling V, Spinella M, Cole M, Godwin AK, Wells W, DiRenzo J.

Cancer Res. 2007 Jan 15;67(2):501-10.


Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia.

Teulière J, Faraldo MM, Deugnier MA, Shtutman M, Ben-Ze'ev A, Thiery JP, Glukhova MA.

Development. 2005 Jan;132(2):267-77.


p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast.

Barbareschi M, Pecciarini L, Cangi MG, Macrì E, Rizzo A, Viale G, Doglioni C.

Am J Surg Pathol. 2001 Aug;25(8):1054-60.


Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, Schwertfeger KL, Lange CA.

Breast Cancer Res. 2011 Sep 17;13(5):R89. doi: 10.1186/bcr2946.


Myoepithelial cell differentiation markers in ductal carcinoma in situ progression.

Russell TD, Jindal S, Agunbiade S, Gao D, Troxell M, Borges VF, Schedin P.

Am J Pathol. 2015 Nov;185(11):3076-89. doi: 10.1016/j.ajpath.2015.07.004.


p63 Sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling.

Memmi EM, Sanarico AG, Giacobbe A, Peschiaroli A, Frezza V, Cicalese A, Pisati F, Tosoni D, Zhou H, Tonon G, Antonov A, Melino G, Pelicci PG, Bernassola F.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3499-504. doi: 10.1073/pnas.1500762112.


Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.

King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC, Weinberg WC.

Carcinogenesis. 2006 Jan;27(1):53-63.


The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland.

Prosperi JR, Becher KR, Willson TA, Collins MH, Witte DP, Goss KH.

J Cell Physiol. 2009 Aug;220(2):319-31. doi: 10.1002/jcp.21766.


Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.

Ramamoorthy S, Tufail R, Hokayem JE, Jorda M, Zhao W, Reis Z, Nawaz Z.

Breast Cancer Res Treat. 2012 Feb;132(1):97-108. doi: 10.1007/s10549-011-1567-2.


Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.

Yazinski SA, Westcott PM, Ong K, Pinkas J, Peters RM, Weiss RS.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21282-7. doi: 10.1073/pnas.0904965106.


The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner.

Serber DW, Rogala A, Makarem M, Rosson GB, Simin K, Godfrey V, Van Dyke T, Eaves CJ, Bultman SJ.

PLoS One. 2012;7(2):e31346. doi: 10.1371/journal.pone.0031346.


Inappropriate P-cadherin expression in the mouse mammary epithelium is compatible with normal mammary gland function.

Radice GL, Sauer CL, Kostetskii I, Peralta Soler A, Knudsen KA.

Differentiation. 2003 Aug;71(6):361-73.

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