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Items: 1 to 20 of 126

1.

Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis.

Greathouse KL, Bredfeldt T, Everitt JI, Lin K, Berry T, Kannan K, Mittelstadt ML, Ho SM, Walker CL.

Mol Cancer Res. 2012 Apr;10(4):546-57. doi: 10.1158/1541-7786.MCR-11-0605.

2.

Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.

Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL.

Mol Endocrinol. 2010 May;24(5):993-1006. doi: 10.1210/me.2009-0438. Epub 2010 Mar 29.

3.

Epigenomic reprogramming of the developing reproductive tract and disease susceptibility in adulthood.

Walker CL.

Birth Defects Res A Clin Mol Teratol. 2011 Aug;91(8):666-71. doi: 10.1002/bdra.20827. Epub 2011 Jun 7. Review.

4.

Developmental exposure to endocrine disrupting chemicals alters the epigenome: Identification of reprogrammed targets.

Prusinski L, Al-Hendy A, Yang Q.

Gynecol Obstet Res. 2016 Jul;3(1):1-6. Epub 2016 May 3.

5.

Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells.

Grimaldi G, Christian M, Steel JH, Henriet P, Poutanen M, Brosens JJ.

Mol Endocrinol. 2011 Nov;25(11):1892-903. doi: 10.1210/me.2011-1139. Epub 2011 Sep 8.

6.

Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation.

Yang Q, Diamond MP, Al-Hendy A.

Front Pharmacol. 2016 Mar 1;7:40. doi: 10.3389/fphar.2016.00040. eCollection 2016. Review.

7.

Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats.

Cook JD, Davis BJ, Goewey JA, Berry TD, Walker CL.

Reprod Sci. 2007 Feb;14(2):121-36.

PMID:
17636224
8.

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).

McCabe MT, Graves AP, Ganji G, Diaz E, Halsey WS, Jiang Y, Smitheman KN, Ott HM, Pappalardi MB, Allen KE, Chen SB, Della Pietra A 3rd, Dul E, Hughes AM, Gilbert SA, Thrall SH, Tummino PJ, Kruger RG, Brandt M, Schwartz B, Creasy CL.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2989-94. doi: 10.1073/pnas.1116418109. Epub 2012 Feb 8.

9.

Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.

Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A, Atadja P, Bhalla K.

Mol Cancer Ther. 2006 Dec;5(12):3096-104.

10.

Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.

Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, Kleer CG.

Cancer Res. 2011 Mar 15;71(6):2360-70. doi: 10.1158/0008-5472.CAN-10-1933.

11.
12.

EZH2 methyltransferase and H3K27 methylation in breast cancer.

Yoo KH, Hennighausen L.

Int J Biol Sci. 2012;8(1):59-65. Epub 2011 Nov 18. Review.

13.

EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.

Cheng AS, Lau SS, Chen Y, Kondo Y, Li MS, Feng H, Ching AK, Cheung KF, Wong HK, Tong JH, Jin H, Choy KW, Yu J, To KF, Wong N, Huang TH, Sung JJ.

Cancer Res. 2011 Jun 1;71(11):4028-39. doi: 10.1158/0008-5472.CAN-10-3342. Epub 2011 Apr 21.

14.

Histone methyltransferase EZH2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-A and diethylstilbestrol.

Bhan A, Hussain I, Ansari KI, Bobzean SA, Perrotti LI, Mandal SS.

J Mol Biol. 2014 Oct 9;426(20):3426-41. doi: 10.1016/j.jmb.2014.07.025. Epub 2014 Aug 1.

PMID:
25088689
15.

EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.

Hwang C, Giri VN, Wilkinson JC, Wright CW, Wilkinson AS, Cooney KA, Duckett CS.

Breast Cancer Res Treat. 2008 Jan;107(2):235-42. Epub 2007 Apr 24.

PMID:
17453341
16.

Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line.

Karanikolas BD, Figueiredo ML, Wu L.

Mol Cancer Res. 2009 Sep;7(9):1456-65. doi: 10.1158/1541-7786.MCR-09-0121. Epub 2009 Sep 1.

17.

Role of hPHF1 in H3K27 methylation and Hox gene silencing.

Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y.

Mol Cell Biol. 2008 Mar;28(5):1862-72. Epub 2007 Dec 17.

18.

Identification of uterine leiomyoma genes developmentally reprogrammed by neonatal exposure to diethylstilbestrol.

Greathouse KL, Cook JD, Lin K, Davis BJ, Berry TD, Bredfeldt TG, Walker CL.

Reprod Sci. 2008 Oct;15(8):765-78. doi: 10.1177/1933719108322440.

PMID:
19017814
19.

Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.

Friedman J, Cho WK, Chu CK, Keedy KS, Archin NM, Margolis DM, Karn J.

J Virol. 2011 Sep;85(17):9078-89. doi: 10.1128/JVI.00836-11. Epub 2011 Jun 29.

20.

Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells.

Dreger H, Ludwig A, Weller A, Stangl V, Baumann G, Meiners S, Stangl K.

Hypertension. 2012 Nov;60(5):1176-83. doi: 10.1161/HYPERTENSIONAHA.112.191098. Epub 2012 Sep 10.

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