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Items: 1 to 20 of 90

1.

Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI.

Gallagher JJ, Zhang X, Ziomek GJ, Jacobs RE, Bearer EL.

Neuroimage. 2012 Apr 15;60(3):1856-66. doi: 10.1016/j.neuroimage.2012.01.132. Epub 2012 Feb 10.

2.

Hippocampal to basal forebrain transport of Mn2+ is impaired by deletion of KLC1, a subunit of the conventional kinesin microtubule-based motor.

Medina CS, Biris O, Falzone TL, Zhang X, Zimmerman AJ, Bearer EL.

Neuroimage. 2017 Jan 15;145(Pt A):44-57. doi: 10.1016/j.neuroimage.2016.09.035. Epub 2016 Oct 14.

3.

Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI.

Wang FH, Appelkvist P, Klason T, Gissberg O, Bogstedt A, Eliason K, Martinsson S, Briem S, Andersson A, Visser SA, Ivarsson M, Lindberg M, Agerman K, Sandin J.

Eur J Neurosci. 2012 Nov;36(9):3165-72. doi: 10.1111/j.1460-9568.2012.08258.x. Epub 2012 Sep 10.

PMID:
22958226
4.

Laminar specific detection of APP induced neurodegeneration and recovery using MEMRI in an olfactory based Alzheimer's disease mouse model.

Saar G, Cheng N, Belluscio L, Koretsky AP.

Neuroimage. 2015 Sep;118:183-92. doi: 10.1016/j.neuroimage.2015.05.045. Epub 2015 May 27.

5.

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.

Rodrigues EM, Weissmiller AM, Goldstein LS.

Hum Mol Genet. 2012 Nov 1;21(21):4587-601. doi: 10.1093/hmg/dds297. Epub 2012 Jul 27.

6.
7.

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.

Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS.

Hum Mol Genet. 2008 Nov 15;17(22):3474-86. doi: 10.1093/hmg/ddn240. Epub 2008 Aug 11.

8.

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.

Gunawardena S, Yang G, Goldstein LS.

Hum Mol Genet. 2013 Oct 1;22(19):3828-43. doi: 10.1093/hmg/ddt237. Epub 2013 May 24.

9.

Manganese-enhanced MRI of the rat visual pathway: acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn(2+).

Thuen M, Berry M, Pedersen TB, Goa PE, Summerfield M, Haraldseth O, Sandvig A, Brekken C.

J Magn Reson Imaging. 2008 Oct;28(4):855-65. doi: 10.1002/jmri.21504.

PMID:
18821627
10.

Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain.

Hernandez CM, Beck WD, Naughton SX, Poddar I, Adam BL, Yanasak N, Middleton C, Terry AV Jr.

Neurotoxicology. 2015 Mar;47:17-26. doi: 10.1016/j.neuro.2015.01.002. Epub 2015 Jan 19.

PMID:
25614231
11.

Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease.

Kins S, Lauther N, Szodorai A, Beyreuther K.

Neurodegener Dis. 2006;3(4-5):218-26. Review.

12.

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.

Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J.

Mol Neurodegener. 2012 Nov 22;7:59. doi: 10.1186/1750-1326-7-59.

13.

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport.

Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, Nakaya T, Hata S, Saito Y, Uchida S, Okada Y, Nairn AC, Davis RJ, Yamamoto T, Kinjo M, Taru H, Suzuki T.

Mol Biol Cell. 2014 Nov 5;25(22):3569-80. doi: 10.1091/mbc.E14-06-1111. Epub 2014 Aug 27.

14.

The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.

Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG.

EMBO J. 1996 Oct 1;15(19):5218-29.

15.

In vivo hippocampal microdialysis reveals impairment of NMDA receptor-cGMP signaling in APP(SW) and APP(SW)/PS1(L166P) Alzheimer's transgenic mice.

Duszczyk M, Kuszczyk M, Guridi M, Lazarewicz JW, Sadowski MJ.

Neurochem Int. 2012 Dec;61(7):976-80. doi: 10.1016/j.neuint.2012.07.017. Epub 2012 Jul 27.

16.

R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer's disease as determined by MEMRI.

Smith KD, Paylor R, Pautler RG.

Magn Reson Med. 2011 May;65(5):1423-9. doi: 10.1002/mrm.22733. Epub 2010 Dec 8.

17.

SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport.

Hermey G, Schmidt N, Bluhm B, Mensching D, Ostermann K, Rupp C, Kuhl D, Kins S.

J Neurochem. 2015 Oct;135(1):60-75. doi: 10.1111/jnc.13221. Epub 2015 Aug 26.

18.

Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice.

Kandimalla KK, Wengenack TM, Curran GL, Gilles EJ, Poduslo JF.

J Pharmacol Exp Ther. 2007 Aug;322(2):541-9. Epub 2007 May 15.

19.

APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone.

Laßek M, Weingarten J, Wegner M, Mueller BF, Rohmer M, Baeumlisberger D, Arrey TN, Hick M, Ackermann J, Acker-Palmer A, Koch I, Müller U, Karas M, Volknandt W.

PLoS Comput Biol. 2016 Apr 19;12(4):e1004832. doi: 10.1371/journal.pcbi.1004832. eCollection 2016 Apr.

20.

Alzheimer's disease: an intracellular movement disorder?

Zhu X, Moreira PI, Smith MA, Perry G.

Trends Mol Med. 2005 Sep;11(9):391-3.

PMID:
16087404

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