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Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs.

Yen HY, Gabet Y, Liu Y, Martin A, Wu NL, Pike MC, Frenkel B, Maxson R, Dubeau L.

Lab Invest. 2012 Jun;92(6):802-11. doi: 10.1038/labinvest.2012.58. Epub 2012 Apr 9.


Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer.

Hong H, Yen HY, Brockmeyer A, Liu Y, Chodankar R, Pike MC, Stanczyk FZ, Maxson R, Dubeau L.

Cancer Res. 2010 Jan 1;70(1):221-8. doi: 10.1158/0008-5472.CAN-09-3232. Epub 2009 Dec 22.


Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent.

Liu Y, Pike MC, Wu N, Lin YG, Mucowski S, Punj V, Tang Y, Yen HY, Stanczyk FZ, Enbom E, Austria T, Widschwendter M, Maxson R, Dubeau L.

PLoS One. 2015 Oct 21;10(10):e0139013. doi: 10.1371/journal.pone.0139013. eCollection 2015.


Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression.

Hu Y, Ghosh S, Amleh A, Yue W, Lu Y, Katz A, Li R.

Oncogene. 2005 Dec 15;24(56):8343-8.


Brca1 is expressed independently of hormonal stimulation in the mouse ovary.

Phillips KW, Goldsworthy SM, Bennett LM, Brownlee HA, Wiseman RW, Davis BJ.

Lab Invest. 1997 Mar;76(3):419-25.


Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors.

Upton DH, Fuller ES, Colvin EK, Walters KA, Jimenez M, Desai R, Handelsman DJ, Howell VM, Allan CM.

Horm Cancer. 2015 Aug;6(4):142-52. doi: 10.1007/s12672-015-0222-5. Epub 2015 May 6.


A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State.

Liu Y, Yen HY, Austria T, Pettersson J, Peti-Peterdi J, Maxson R, Widschwendter M, Dubeau L.

EBioMedicine. 2015 Sep 9;2(10):1318-30. doi: 10.1016/j.ebiom.2015.08.034. eCollection 2015 Oct.


Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells.

Lu Y, Amleh A, Sun J, Jin X, McCullough SD, Baer R, Ren D, Li R, Hu Y.

Mol Endocrinol. 2007 Mar;21(3):651-63. Epub 2006 Dec 21.


Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo.

Bayne S, Li H, Jones ME, Pinto AR, van Sinderen M, Drummond A, Simpson ER, Liu JP.

Protein Cell. 2011 Apr;2(4):333-46. doi: 10.1007/s13238-011-1033-2. Epub 2011 May 15.


Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells.

Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Deng C, Pike MC, Shuler CF, Maxson R, Dubeau L.

Curr Biol. 2005 Mar 29;15(6):561-5.


IGF-1 gene expression is differentially regulated by estrogen receptors α and β in mouse endometrial stromal cells and ovarian granulosa cells.

Ogo Y, Taniuchi S, Ojima F, Hayashi S, Murakami I, Saito Y, Takeuchi S, Kudo T, Takahashi S.

J Reprod Dev. 2014;60(3):216-23. Epub 2014 Mar 25.


Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19).

Guo J, Yuan Y, Lu D, Du B, Xiong L, Shi J, Yang L, Liu W, Yuan X, Zhang G, Wang F.

Toxicol Appl Pharmacol. 2014 Aug 15;279(1):23-32. doi: 10.1016/j.taap.2014.05.008. Epub 2014 May 20.


Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS.

Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu XM, Zhang XH, Chung YW, Huang P, Huang H, Chan HC.

J Clin Endocrinol Metab. 2012 Mar;97(3):923-32. doi: 10.1210/jc.2011-1363. Epub 2011 Dec 14.


Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53.

Quinn BA, Brake T, Hua X, Baxter-Jones K, Litwin S, Ellenson LH, Connolly DC.

PLoS One. 2009 Dec 31;4(12):e8404. doi: 10.1371/journal.pone.0008404.


The prevention of breast cancer through reduced ovarian steroid exposure.

Spicer DV, Pike MC.

Acta Oncol. 1992;31(2):167-74. Review.


Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure.

Andreu-Vieyra C, Chen R, Matzuk MM.

Mol Endocrinol. 2008 Sep;22(9):2141-61. doi: 10.1210/me.2008-0033. Epub 2008 Jul 3.


The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro.

McNatty KP, Makris A, DeGrazia C, Osathanondh R, Ryan KJ.

J Clin Endocrinol Metab. 1979 Nov;49(5):687-99.


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