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Items: 1 to 20 of 129

1.

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease.

Hickey MA, Zhu C, Medvedeva V, Lerner RP, Patassini S, Franich NR, Maiti P, Frautschy SA, Zeitlin S, Levine MS, Chesselet MF.

Mol Neurodegener. 2012 Apr 4;7:12. doi: 10.1186/1750-1326-7-12.

2.

Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease.

Hickey MA, Zhu C, Medvedeva V, Franich NR, Levine MS, Chesselet MF.

Mol Cell Neurosci. 2012 Feb;49(2):149-57. doi: 10.1016/j.mcn.2011.10.007. Epub 2011 Oct 20.

3.

Sex differences in behavior and striatal ascorbate release in the 140 CAG knock-in mouse model of Huntington's disease.

Dorner JL, Miller BR, Barton SJ, Brock TJ, Rebec GV.

Behav Brain Res. 2007 Mar 12;178(1):90-7. Epub 2007 Jan 18.

4.

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice.

Hickey MA, Kosmalska A, Enayati J, Cohen R, Zeitlin S, Levine MS, Chesselet MF.

Neuroscience. 2008 Nov 11;157(1):280-95. doi: 10.1016/j.neuroscience.2008.08.041. Epub 2008 Aug 27.

5.

Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.

Wegrzynowicz M, Bichell TJ, Soares BD, Loth MK, McGlothan JS, Mori S, Alikhan FS, Hua K, Coughlin JM, Holt HK, Jetter CS, Pomper MG, Osmand AP, Guilarte TR, Bowman AB.

J Huntingtons Dis. 2015;4(1):17-36.

6.

Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.

Rising AC, Xu J, Carlson A, Napoli VV, Denovan-Wright EM, Mandel RJ.

Exp Neurol. 2011 Apr;228(2):173-82. doi: 10.1016/j.expneurol.2010.12.017. Epub 2010 Dec 28.

7.

Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

Menalled LB, Kudwa AE, Miller S, Fitzpatrick J, Watson-Johnson J, Keating N, Ruiz M, Mushlin R, Alosio W, McConnell K, Connor D, Murphy C, Oakeshott S, Kwan M, Beltran J, Ghavami A, Brunner D, Park LC, Ramboz S, Howland D.

PLoS One. 2012;7(12):e49838. doi: 10.1371/journal.pone.0049838. Epub 2012 Dec 20.

8.

An independent study of the preclinical efficacy of C2-8 in the R6/2 transgenic mouse model of Huntington's disease.

Wang N, Lu XH, Sandoval SV, Yang XW.

J Huntingtons Dis. 2013;2(4):443-51. doi: 10.3233/JHD-130074.

9.

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

Heikkinen T, Lehtimäki K, Vartiainen N, Puoliväli J, Hendricks SJ, Glaser JR, Bradaia A, Wadel K, Touller C, Kontkanen O, Yrjänheikki JM, Buisson B, Howland D, Beaumont V, Munoz-Sanjuan I, Park LC.

PLoS One. 2012;7(12):e50717. doi: 10.1371/journal.pone.0050717. Epub 2012 Dec 20.

10.

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.

Smith GA, Rocha EM, McLean JR, Hayes MA, Izen SC, Isacson O, Hallett PJ.

Hum Mol Genet. 2014 Sep 1;23(17):4510-27. doi: 10.1093/hmg/ddu166. Epub 2014 Apr 12.

PMID:
24728190
11.

Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease.

Wang Z, Stefanko DP, Guo Y, Toy WA, Petzinger GM, Jakowec MW, Holschneider DP.

Neuroreport. 2016 Jun 15;27(9):632-9. doi: 10.1097/WNR.0000000000000587.

PMID:
27082842
12.

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease.

Peng Q, Wu B, Jiang M, Jin J, Hou Z, Zheng J, Zhang J, Duan W.

PLoS One. 2016 Feb 9;11(2):e0148839. doi: 10.1371/journal.pone.0148839. eCollection 2016.

13.

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.

14.

Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice.

Brooks S, Higgs G, Jones L, Dunnett SB.

Brain Res Bull. 2012 Jun 1;88(2-3):182-8. doi: 10.1016/j.brainresbull.2010.05.004. Epub 2010 May 8.

PMID:
20457230
15.

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.

Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF.

J Comp Neurol. 2003 Oct 6;465(1):11-26.

PMID:
12926013
16.

Protection by dietary restriction in the YAC128 mouse model of Huntington's disease: Relation to genes regulating histone acetylation and HTT.

Moreno CL, Ehrlich ME, Mobbs CV.

Neurobiol Dis. 2016 Jan;85:25-34. doi: 10.1016/j.nbd.2015.09.012. Epub 2015 Oct 17.

17.

Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington's Disease.

Rattray I, Smith EJ, Crum WR, Walker TA, Gale R, Bates GP, Modo M.

PLoS One. 2017 Jan 18;12(1):e0168556. doi: 10.1371/journal.pone.0168556. eCollection 2017.

18.

Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease.

Cummings DM, Cepeda C, Levine MS.

ASN Neuro. 2010 Jun 18;2(3):e00036. doi: 10.1042/AN20100007.

19.

A Longitudinal Motor Characterisation of the HdhQ111 Mouse Model of Huntington's Disease.

Yhnell E, Dunnett SB, Brooks SP.

J Huntingtons Dis. 2016 May 31;5(2):149-61. doi: 10.3233/JHD-160191.

20.

Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein.

Cheng PH, Li CL, Her LS, Chang YF, Chan AW, Chen CM, Yang SH.

Brain Struct Funct. 2013 Jan;218(1):283-94. doi: 10.1007/s00429-012-0401-x. Epub 2012 Mar 16.

PMID:
22422149

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