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A TIRF microscopy technique for real-time, simultaneous imaging of the TCR and its associated signaling proteins.

Crites TJ, Chen L, Varma R.

J Vis Exp. 2012 Mar 22;(61). pii: 3892. doi: 10.3791/3892.


Real-time live imaging of T-cell signaling complex formation.

Noy E, Pauker MH, Barda-Saad M.

J Vis Exp. 2013 Jun 23;(76). doi: 10.3791/50076.


Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains.

Montixi C, Langlet C, Bernard AM, Thimonier J, Dubois C, Wurbel MA, Chauvin JP, Pierres M, He HT.

EMBO J. 1998 Sep 15;17(18):5334-48.


Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.

Le Bras S, Foucault I, Foussat A, Brignone C, Acuto O, Deckert M.

J Biol Chem. 2004 Apr 9;279(15):15550-60.


Lck is required for activation-induced T cell death after TCR ligation with partial agonists.

Yu XZ, Levin SD, Madrenas J, Anasetti C.

J Immunol. 2004 Feb 1;172(3):1437-43.


Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML.

Nature. 2014 Mar 6;507(7490):118-23. doi: 10.1038/nature12951.


The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex.

Thome M, Germain V, DiSanto JP, Acuto O.

Eur J Immunol. 1996 Sep;26(9):2093-2100.


Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay.

Axmann M, Schütz GJ, Huppa JB.

J Vis Exp. 2015 Oct 30;(105):e53157. doi: 10.3791/53157.


Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling.

Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH.

J Biol Chem. 2001 Jun 1;276(22):18908-14.


Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis.

Størvold GL, Landskron J, Strozynski M, Arntzen MØ, Koehler CJ, Kalland ME, Taskén K, Thiede B.

J Proteomics. 2013 Oct 8;91:344-57. doi: 10.1016/j.jprot.2013.07.019.


T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.

Dong S, Corre B, Nika K, Pellegrini S, Michel F.

PLoS One. 2010 Nov 30;5(11):e15114. doi: 10.1371/journal.pone.0015114.

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