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Items: 1 to 20 of 78


Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism.

Welf ES, Ahmed S, Johnson HE, Melvin AT, Haugh JM.

J Cell Biol. 2012 Apr 2;197(1):105-14. doi: 10.1083/jcb.201108152.


In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling.

Melvin AT, Welf ES, Wang Y, Irvine DJ, Haugh JM.

Biophys J. 2011 Apr 20;100(8):1893-901. doi: 10.1016/j.bpj.2011.02.047.


Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.

Weiger MC, Wang CC, Krajcovic M, Melvin AT, Rhoden JJ, Haugh JM.

J Cell Sci. 2009 Feb 1;122(Pt 3):313-23. doi: 10.1242/jcs.037564. Epub 2009 Jan 6.


The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts.

Thevathasan JV, Tan E, Zheng H, Lin YC, Li Y, Inoue T, Fivaz M.

Mol Biol Cell. 2013 Jul;24(14):2228-37. doi: 10.1091/mbc.E12-12-0905. Epub 2013 May 15.


Ras activated ERK and PI3K pathways differentially affect directional movement of cultured fibroblasts.

Sepe L, Ferrari MC, Cantarella C, Fioretti F, Paolella G.

Cell Physiol Biochem. 2013;31(1):123-42. doi: 10.1159/000343355. Epub 2013 Jan 29.


PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.

Zeller KS, Idevall-Hagren O, Stefansson A, Velling T, Jackson SP, Downward J, Tengholm A, Johansson S.

Cell Signal. 2010 Dec;22(12):1838-48. doi: 10.1016/j.cellsig.2010.07.011. Epub 2010 Jul 25. Erratum in: Cell Signal. 2012 Apr;24(4):971-2.


Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling.

Weiger MC, Ahmed S, Welf ES, Haugh JM.

Biophys J. 2010 Jan 6;98(1):67-75. doi: 10.1016/j.bpj.2009.09.051.


F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling.

Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM.

J Cell Biol. 2015 Feb 16;208(4):443-55. doi: 10.1083/jcb.201406102. Epub 2015 Feb 9.


Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species.

Bäumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M, Rosenkranz S.

J Biol Chem. 2008 Mar 21;283(12):7864-76. Epub 2007 Dec 10.


IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade.

Mitra A, Raychaudhuri SK, Raychaudhuri SP.

Cytokine. 2012 Oct;60(1):38-42. doi: 10.1016/j.cyto.2012.06.316. Epub 2012 Jul 25.


Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells.

Henry MK, Nimbalkar D, Hohl RJ, Quelle FW.

Exp Cell Res. 2004 Sep 10;299(1):257-66.


Specific roles for the PI3K and the MEK-ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model.

Menu E, Kooijman R, Van Valckenborgh E, Asosingh K, Bakkus M, Van Camp B, Vanderkerken K.

Br J Cancer. 2004 Mar 8;90(5):1076-83.


ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.

Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH.

Oncogene. 2005 Apr 28;24(19):3154-65.


Suppression of the PI3K-Akt pathway is involved in the decreased adhesion and migration of bone marrow-derived mesenchymal stem cells from non-obese diabetic mice.

Li L, Xia Y, Wang Z, Cao X, Da Z, Guo G, Qian J, Liu X, Fan Y, Sun L, Sang A, Gu Z.

Cell Biol Int. 2011 Sep;35(9):961-6. doi: 10.1042/CBI20100544. Erratum in: Cell Biol Int. 2011;35(10):1063.


Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker.

Jamieson JS, Tumbarello DA, Hallé M, Brown MC, Tremblay ML, Turner CE.

J Cell Sci. 2005 Dec 15;118(Pt 24):5835-47. Epub 2005 Nov 29.


Quantitative analysis of phosphoinositide 3-kinase (PI3K) signaling using live-cell total internal reflection fluorescence (TIRF) microscopy.

Johnson HE, Haugh JM.

Curr Protoc Cell Biol. 2013 Dec 2;61:14.14.1-14.14.24. doi: 10.1002/0471143030.cb1414s61.


Deposition of laminin 5 by keratinocytes regulates integrin adhesion and signaling.

Nguyen BP, Gil SG, Carter WG.

J Biol Chem. 2000 Oct 13;275(41):31896-907.


The tight junction protein, occludin, regulates the directional migration of epithelial cells.

Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, Huang Q, Zhang F, Bao H, Jia L, Wu X, Zhu X, Zhang X, Zhang Z, Chen Z.

Dev Cell. 2010 Jan 19;18(1):52-63. doi: 10.1016/j.devcel.2009.12.008.


H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblasts.

Fuentes-Calvo I, Blázquez-Medela AM, Eleno N, Santos E, López-Novoa JM, Martínez-Salgado C.

Am J Physiol Cell Physiol. 2012 Feb 15;302(4):C686-97. doi: 10.1152/ajpcell.00103.2011. Epub 2011 Nov 16.

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