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NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.

Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, Shimada Y, Arima C, Kato S, Tomida S, Suzuki M, Osada H, Takahashi T.

Cancer Cell. 2012 Mar 20;21(3):348-61. doi: 10.1016/j.ccr.2012.02.008.


Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma.

Ida L, Yamaguchi T, Yanagisawa K, Kajino T, Shimada Y, Suzuki M, Takahashi T.

Cancer Sci. 2016 Feb;107(2):155-61. doi: 10.1111/cas.12858. Epub 2016 Feb 8.


ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.

Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, Hotta N, Shimada Y, Isomura H, Suzuki M, Fujimoto T, Takahashi T.

Nat Commun. 2016 Jan 4;7:10060. doi: 10.1038/ncomms10060.


Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells.

Sutton P, Borgia JA, Bonomi P, Plate JM.

Mol Cancer. 2013 Jul 16;12:76. doi: 10.1186/1476-4598-12-76.


Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis.

Gentile A, Lazzari L, Benvenuti S, Trusolino L, Comoglio PM.

Cancer Res. 2011 Apr 15;71(8):3132-41. doi: 10.1158/0008-5472.CAN-10-2662. Epub 2011 Apr 12.


Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells.

Akca H, Tani M, Hishida T, Matsumoto S, Yokota J.

Lung Cancer. 2006 Oct;54(1):25-33. Epub 2006 Jul 26.


Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation.

Contessa JN, Abell A, Mikkelsen RB, Valerie K, Schmidt-Ullrich RK.

Breast Cancer Res Treat. 2006 Jan;95(1):17-27.


Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma.

Liu Y, Yang H, Chen T, Luo Y, Xu Z, Li Y, Yang J.

PLoS One. 2015 May 15;10(5):e0127092. doi: 10.1371/journal.pone.0127092. eCollection 2015.


Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.

Yamada T, Matsumoto K, Wang W, Li Q, Nishioka Y, Sekido Y, Sone S, Yano S.

Clin Cancer Res. 2010 Jan 1;16(1):174-83. doi: 10.1158/1078-0432.CCR-09-1204. Epub 2009 Dec 15.


Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells.

Su JC, Lin KL, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR.

Life Sci. 2010 Jan 30;86(5-6):207-13. doi: 10.1016/j.lfs.2009.12.006. Epub 2009 Dec 28.


NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.

Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T.

Cancer Cell. 2013 Jun 10;23(6):718-23. doi: 10.1016/j.ccr.2013.04.002. Review.


Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.

Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, Yuspa SH.

J Biol Chem. 1996 Mar 8;271(10):5325-31.


Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF.

Deb TB, Su L, Wong L, Bonvini E, Wells A, David M, Johnson GR.

J Biol Chem. 2001 May 4;276(18):15554-60. Epub 2001 Feb 5.


c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential.

Marcotte R, Zhou L, Kim H, Roskelly CD, Muller WJ.

Mol Cell Biol. 2009 Nov;29(21):5858-71. doi: 10.1128/MCB.01731-08. Epub 2009 Aug 24.


Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling.

Conde E, Angulo B, Tang M, Morente M, Torres-Lanzas J, Lopez-Encuentra A, Lopez-Rios F, Sanchez-Cespedes M.

Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):710-7.


EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF.

Chou YT, Lin HH, Lien YC, Wang YH, Hong CF, Kao YR, Lin SC, Chang YC, Lin SY, Chen SJ, Chen HC, Yeh SD, Wu CW.

Cancer Res. 2010 Nov 1;70(21):8822-31. doi: 10.1158/0008-5472.CAN-10-0638. Epub 2010 Oct 26.


Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.

Samarakoon R, Higgins CE, Higgins SP, Kutz SM, Higgins PJ.

J Cell Physiol. 2005 Jul;204(1):236-46.


p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.

Wu W, Silbajoris RA, Whang YE, Graves LM, Bromberg PA, Samet JM.

Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L883-9. Epub 2005 Jun 24.

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