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Items: 1 to 20 of 215

1.

Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.

Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, Blond F, Delhomme N, Hahn M, Reifenberger J, Reifenberger G, Lichter P.

PLoS Genet. 2012;8(3):e1002572. doi: 10.1371/journal.pgen.1002572. Epub 2012 Mar 15.

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Thickened area of external granular layer and Ki-67 positive focus are early events of medulloblastoma in Ptch1⁺/⁻ mice.

Matsuo S, Takahashi M, Inoue K, Tamura K, Irie K, Kodama Y, Nishikawa A, Yoshida M.

Exp Toxicol Pathol. 2013 Sep;65(6):863-73. doi: 10.1016/j.etp.2012.12.005. Epub 2013 Jan 28.

PMID:
23369240
4.

Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons.

Farioli-Vecchioli S, Cinà I, Ceccarelli M, Micheli L, Leonardi L, Ciotti MT, De Bardi M, Di Rocco C, Pallini R, Cavallaro S, Tirone F.

J Neurosci. 2012 Oct 31;32(44):15547-64. doi: 10.1523/JNEUROSCI.0412-12.2012.

5.

Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.

Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7331-6. Epub 2003 May 30.

6.

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression.

Thomas WD, Chen J, Gao YR, Cheung B, Koach J, Sekyere E, Norris MD, Haber M, Ellis T, Wainwright B, Marshall GM.

Oncogene. 2009 Apr 2;28(13):1605-15. doi: 10.1038/onc.2009.3. Epub 2009 Feb 23.

PMID:
19234491
7.

Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum.

Tanori M, Santone M, Mancuso M, Pasquali E, Leonardi S, Di Majo V, Rebessi S, Saran A, Pazzaglia S.

Mol Cancer. 2010 Mar 9;9:53. doi: 10.1186/1476-4598-9-53.

8.

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.

Vaillant C, Valdivieso P, Nuciforo S, Kool M, Schwarzentruber-Schauerte A, Méreau H, Cabuy E, Lobrinus JA, Pfister S, Zuniga A, Frank S, Zeller R.

PLoS One. 2015 Apr 22;10(4):e0124870. doi: 10.1371/journal.pone.0124870. eCollection 2015.

9.

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ.

Development. 2005 May;132(10):2425-39. Epub 2005 Apr 20.

10.

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM.

Development. 2008 Oct;135(19):3291-300. doi: 10.1242/dev.022871. Epub 2008 Aug 28.

11.

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors.

Mille F, Tamayo-Orrego L, Lévesque M, Remke M, Korshunov A, Cardin J, Bouchard N, Izzi L, Kool M, Northcott PA, Taylor MD, Pfister SM, Charron F.

Dev Cell. 2014 Oct 13;31(1):34-47. doi: 10.1016/j.devcel.2014.08.010. Epub 2014 Sep 25.

12.

Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3.

Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F.

FASEB J. 2007 Jul;21(9):2215-25. Epub 2007 Mar 19.

13.

Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth.

Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, Kim KJ, Laterra J, Fults DW.

Cancer Res. 2008 Oct 1;68(19):7838-45. doi: 10.1158/0008-5472.CAN-08-1899.

14.

Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma.

Lee SJ, Lindsey S, Graves B, Yoo S, Olson JM, Langhans SA.

PLoS One. 2013 Aug 9;8(8):e71455. doi: 10.1371/journal.pone.0071455. eCollection 2013.

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Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.

Flora A, Klisch TJ, Schuster G, Zoghbi HY.

Science. 2009 Dec 4;326(5958):1424-7. doi: 10.1126/science.1181453. Erratum in: Science. 2010 Mar 19;327(5972):1454.

17.

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.

Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, Van Lohuizen M, Marino S.

Nature. 2004 Mar 18;428(6980):337-41.

PMID:
15029199
18.

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells.

Ferretti E, De Smaele E, Miele E, Laneve P, Po A, Pelloni M, Paganelli A, Di Marcotullio L, Caffarelli E, Screpanti I, Bozzoni I, Gulino A.

EMBO J. 2008 Oct 8;27(19):2616-27. doi: 10.1038/emboj.2008.172. Epub 2008 Aug 28.

19.

Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.

Briggs KJ, Corcoran-Schwartz IM, Zhang W, Harcke T, Devereux WL, Baylin SB, Eberhart CG, Watkins DN.

Genes Dev. 2008 Mar 15;22(6):770-85. doi: 10.1101/gad.1640908. Erratum in: Genes Dev. 2008 May 15;22(10):1410.

20.

Inhibitory potential of postnatal treatment with cyclopamine, a hedgehog signaling inhibitor, on medulloblastoma development in Ptch1 heterozygous mice.

Matsuo S, Takahashi M, Inoue K, Tamura K, Irie K, Kodama Y, Nishikawa A, Yoshida M.

Toxicol Pathol. 2014 Dec;42(8):1174-87. doi: 10.1177/0192623314530194. Epub 2014 May 26.

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