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Items: 1 to 20 of 138

1.

A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death.

Baldwin AC, Green CD, Olson LK, Moxley MA, Corbett JA.

Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1390-8. doi: 10.1152/ajpendo.00519.2011. Epub 2012 Mar 20.

2.

Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response.

Sommerweiss D, Gorski T, Richter S, Garten A, Kiess W.

Biochem Biophys Res Commun. 2013 Nov 29;441(4):770-6. doi: 10.1016/j.bbrc.2013.10.130. Epub 2013 Nov 1.

3.

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17.

4.

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.

PMID:
15297438
5.

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.

Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2008 Apr;57(4):846-59. doi: 10.2337/db07-0595. Epub 2008 Jan 3.

6.

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. doi: 10.1152/ajpendo.00478.2007. Epub 2008 Jan 15.

7.

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

Diabetes. 2008 Nov;57(11):3034-44. doi: 10.2337/db07-1802. Epub 2008 Jun 30.

8.

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG.

Diabetes. 2001 Aug;50(8):1771-7.

9.

Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate.

Thörn K, Bergsten P.

J Cell Biochem. 2010 Oct 1;111(2):497-507. doi: 10.1002/jcb.22734.

PMID:
20524206
10.

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.

Green CD, Olson LK.

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E640-9. doi: 10.1152/ajpendo.00544.2010. Epub 2011 Jan 25.

11.

A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS).

Choi SE, Lee YJ, Jang HJ, Lee KW, Kim YS, Jun HS, Kang SS, Chun J, Kang Y.

Arch Biochem Biophys. 2008 Jul 15;475(2):109-14. doi: 10.1016/j.abb.2008.04.015. Epub 2008 Apr 18.

PMID:
18455496
12.

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A.

Endocrinology. 2006 Jul;147(7):3398-407. Epub 2006 Apr 6.

PMID:
16601139
14.

ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells.

Chu KY, Lin Y, Hendel A, Kulpa JE, Brownsey RW, Johnson JD.

J Biol Chem. 2010 Oct 15;285(42):32606-15. doi: 10.1074/jbc.M110.157172. Epub 2010 Aug 7.

15.

Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression.

Sol EM, Sargsyan E, Akusjärvi G, Bergsten P.

Biochem Biophys Res Commun. 2008 Oct 31;375(4):517-21. doi: 10.1016/j.bbrc.2008.08.013. Epub 2008 Aug 13.

PMID:
18706397
16.

Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway.

Chen YY, Sun LQ, Wang BA, Zou XM, Mu YM, Lu JM.

Int J Mol Med. 2013 Dec;32(6):1401-6. doi: 10.3892/ijmm.2013.1530. Epub 2013 Oct 18.

PMID:
24142192
18.

Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response.

Sargsyan E, Artemenko K, Manukyan L, Bergquist J, Bergsten P.

Biochim Biophys Acta. 2016 Sep;1861(9 Pt A):1151-60. doi: 10.1016/j.bbalip.2016.06.012. Epub 2016 Jun 22.

PMID:
27344025
19.

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

Metabolism. 2002 Oct;51(10):1340-7.

PMID:
12370856
20.

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M.

Diabetes. 2009 Dec;58(12):2851-62. doi: 10.2337/db09-0685. Epub 2009 Aug 31.

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