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A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis.

Xu T, Tripathi SK, Feng Q, Lorenz MC, Wright MA, Jacob MR, Mask MM, Baerson SR, Li XC, Clark AM, Agarwal AK.

Antimicrob Agents Chemother. 2012 Jun;56(6):2894-907. doi: 10.1128/AAC.05663-11. Epub 2012 Mar 19.


Potent in vitro antifungal activities of naturally occurring acetylenic acids.

Li XC, Jacob MR, Khan SI, Ashfaq MK, Babu KS, Agarwal AK, Elsohly HN, Manly SP, Clark AM.

Antimicrob Agents Chemother. 2008 Jul;52(7):2442-8. doi: 10.1128/AAC.01297-07. Epub 2008 May 5.


Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.

Agarwal AK, Xu T, Jacob MR, Feng Q, Lorenz MC, Walker LA, Clark AM.

Eukaryot Cell. 2008 Feb;7(2):387-400. Epub 2007 Dec 21.


Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.

Li XC, Jacob MR, ElSohly HN, Nagle DG, Smillie TJ, Walker LA, Clark AM.

J Nat Prod. 2003 Aug;66(8):1132-5.


Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.

Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.

Antimicrob Agents Chemother. 1995 Nov;39(11):2378-86.


2,6-hexadecadiynoic acid and 2,6-nonadecadiynoic acid: novel synthesized acetylenic fatty acids as potent antifungal agents.

Carballeira NM, Sanabria D, Cruz C, Parang K, Wan B, Franzblau S.

Lipids. 2006 May;41(5):507-11.


Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants.

Sun N, Fonzi W, Chen H, She X, Zhang L, Zhang L, Calderone R.

Antimicrob Agents Chemother. 2013 Jan;57(1):532-42. doi: 10.1128/AAC.01520-12. Epub 2012 Nov 12.


The marine sponge-derived polyketide endoperoxide plakortide F acid mediates its antifungal activity by interfering with calcium homeostasis.

Xu T, Feng Q, Jacob MR, Avula B, Mask MM, Baerson SR, Tripathi SK, Mohammed R, Hamann MT, Khan IA, Walker LA, Clark AM, Agarwal AK.

Antimicrob Agents Chemother. 2011 Apr;55(4):1611-21. doi: 10.1128/AAC.01022-10. Epub 2011 Feb 7.


Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae.

Coste AT, Ramsdale M, Ischer F, Sanglard D.

Microbiology. 2008 May;154(Pt 5):1491-501. doi: 10.1099/mic.0.2007/016063-0.


ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.

Holmes AR, Lin YH, Niimi K, Lamping E, Keniya M, Niimi M, Tanabe K, Monk BC, Cannon RD.

Antimicrob Agents Chemother. 2008 Nov;52(11):3851-62. doi: 10.1128/AAC.00463-08. Epub 2008 Aug 18.


Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase.

Billack B, Santoro M, Lau-Cam C.

Microb Drug Resist. 2009 Jun;15(2):77-83. doi: 10.1089/mdr.2009.0872.


Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans.

Barker KS, Crisp S, Wiederhold N, Lewis RE, Bareither B, Eckstein J, Barbuch R, Bard M, Rogers PD.

J Antimicrob Chemother. 2004 Aug;54(2):376-85. Epub 2004 Jun 16.


Fatty acid profile and influence of oxythiamine on fatty acid content in Malassezia pachydermatis, Candida albicans and Saccharomyces cerevisiae.

Tylicki A, Siemieniuk M, Dobrzyn P, Ziolkowska G, Nowik M, Czyzewska U, Pyrkowska A.

Mycoses. 2012 May;55(3):e106-13. doi: 10.1111/j.1439-0507.2011.02152.x. Epub 2011 Nov 9.


Total synthesis and further scrutiny of the in vitro antifungal activity of 6-nonadecynoic acid.

Carballeira NM, Sanabria D, Parang K.

Arch Pharm (Weinheim). 2005 Sep;338(9):441-3.


Potent synergistic effect of doxycycline with fluconazole against Candida albicans is mediated by interference with iron homeostasis.

Fiori A, Van Dijck P.

Antimicrob Agents Chemother. 2012 Jul;56(7):3785-96. doi: 10.1128/AAC.06017-11. Epub 2012 May 7.


Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans.

Gamarra S, Rocha EM, Zhang YQ, Park S, Rao R, Perlin DS.

Antimicrob Agents Chemother. 2010 May;54(5):1753-61. doi: 10.1128/AAC.01728-09. Epub 2010 Mar 1.

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