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Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.

Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA.

J Biol Chem. 2012 Apr 27;287(18):15076-86. doi: 10.1074/jbc.M111.332361.


An extended CCR5 ECL2 peptide forms a helix that binds HIV-1 gp120 through non-specific hydrophobic interactions.

Abayev M, Moseri A, Tchaicheeyan O, Kessler N, Arshava B, Naider F, Scherf T, Anglister J.

FEBS J. 2015 May;282(10):1906-21. doi: 10.1111/febs.13243.


A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120.

Quinlan BD, Joshi VR, Gardner MR, Ebrahimi KH, Farzan M.

J Virol. 2014 Mar;88(6):3353-8. doi: 10.1128/JVI.03800-13.


Peptide ligands selected with CD4-induced epitopes on native dualtropic HIV-1 envelope proteins mimic extracellular coreceptor domains and bind to HIV-1 gp120 independently of coreceptor usage.

Dervillez X, Klaukien V, Dürr R, Koch J, Kreutz A, Haarmann T, Stoll M, Lee D, Carlomagno T, Schnierle B, Möbius K, Königs C, Griesinger C, Dietrich U.

J Virol. 2010 Oct;84(19):10131-8. doi: 10.1128/JVI.00165-10.


Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120.

Cormier EG, Persuh M, Thompson DA, Lin SW, Sakmar TP, Olson WC, Dragic T.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5762-7.


Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry.

Lam SN, Acharya P, Wyatt R, Kwong PD, Bewley CA.

Bioorg Med Chem. 2008 Dec 1;16(23):10113-20. doi: 10.1016/j.bmc.2008.10.005.


CCR5 N-terminus peptides enhance X4 HIV-1 infection by CXCR4 up-regulation.

Dettin M, Zanchetta M, Pasquato A, Borrello M, Piatier-Tonneau D, Di Bello C, De Rossi A.

Biochem Biophys Res Commun. 2003 Aug 1;307(3):640-6.


Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120.

Brower ET, Schön A, Klein JC, Freire E.

Biochemistry. 2009 Feb 3;48(4):779-85. doi: 10.1021/bi8021476.


A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.

Siciliano SJ, Kuhmann SE, Weng Y, Madani N, Springer MS, Lineberger JE, Danzeisen R, Miller MD, Kavanaugh MP, DeMartino JA, Kabat D.

J Biol Chem. 1999 Jan 22;274(4):1905-13.


A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry.

Farzan M, Vasilieva N, Schnitzler CE, Chung S, Robinson J, Gerard NP, Gerard C, Choe H, Sodroski J.

J Biol Chem. 2000 Oct 27;275(43):33516-21.


A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti- HIV-1 activity independently of coreceptor usage.

Connell BJ, Baleux F, Coic YM, Clayette P, Bonnaffé D, Lortat-Jacob H.

Chem Biol. 2012 Jan 27;19(1):131-9. doi: 10.1016/j.chembiol.2011.12.009.


Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.

Lin G, Bertolotti-Ciarlet A, Haggarty B, Romano J, Nolan KM, Leslie GJ, Jordan AP, Huang CC, Kwong PD, Doms RW, Hoxie JA.

J Virol. 2007 Sep;81(18):9956-66.


Theoretical studies on the interactions and interferences of HIV-1 glycoprotein gp120 and its coreceptor CCR5.

Da LT, Wu YD.

J Chem Inf Model. 2011 Feb 28;51(2):359-69. doi: 10.1021/ci1003448.


Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120: implications of the interaction with chemokine receptor CCR5.

Morikis D, Rizos AK, Spandidos DA, Krambovitis E.

Int J Mol Med. 2007 Mar;19(3):343-51.


Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.

Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD.

Science. 2007 Sep 28;317(5846):1930-4.

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