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p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, Zwaka TP, Kyba M, Barton MC.

PLoS Biol. 2012;10(2):e1001268. doi: 10.1371/journal.pbio.1001268. Epub 2012 Feb 28.


Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation.

Zhang ZN, Chung SK, Xu Z, Xu Y.

Stem Cells. 2014 Jan;32(1):157-65. doi: 10.1002/stem.1532.


Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?

Gunaratne PH.

Curr Stem Cell Res Ther. 2009 Sep;4(3):168-77. Review.


Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells.

Card DA, Hebbar PB, Li L, Trotter KW, Komatsu Y, Mishina Y, Archer TK.

Mol Cell Biol. 2008 Oct;28(20):6426-38. doi: 10.1128/MCB.00359-08. Epub 2008 Aug 18.


OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation.

Ng WL, Chen G, Wang M, Wang H, Story M, Shay JW, Zhang X, Wang J, Amin AR, Hu B, Cucinotta FA, Wang Y.

Cell Death Dis. 2014 Jan 23;5:e1024. doi: 10.1038/cddis.2013.563.


p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells.

Wang B, Li D, Kovalchuk O.

Cell Cycle. 2013 Jul 1;12(13):2073-83. doi: 10.4161/cc.25135. Epub 2013 Jun 6.


Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells.

Akdemir KC, Jain AK, Allton K, Aronow B, Xu X, Cooney AJ, Li W, Barton MC.

Nucleic Acids Res. 2014 Jan;42(1):205-23. doi: 10.1093/nar/gkt866. Epub 2013 Sep 27.


miR-34a regulates mouse neural stem cell differentiation.

Aranha MM, Santos DM, Solá S, Steer CJ, Rodrigues CM.

PLoS One. 2011;6(8):e21396. doi: 10.1371/journal.pone.0021396. Epub 2011 Aug 3.


MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.

Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS.

Cell. 2009 May 15;137(4):647-58. doi: 10.1016/j.cell.2009.02.038. Epub 2009 Apr 30.


A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation.

Rosa A, Brivanlou AH.

EMBO J. 2011 Jan 19;30(2):237-48. doi: 10.1038/emboj.2010.319. Epub 2010 Dec 10.


Functional analysis of the acetylation of human p53 in DNA damage responses.

Chung SK, Zhu S, Xu Y, Fu X.

Protein Cell. 2014 Jul;5(7):544-51. doi: 10.1007/s13238-014-0048-x. Epub 2014 Apr 2.


Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.

Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T, Appella E, Nagashima M, Takenoshita S, Yokota J, Harris CC.

Cancer Res. 2008 May 1;68(9):3193-203. doi: 10.1158/0008-5472.CAN-07-2780.


Regulation of apoptosis and differentiation by p53 in human embryonic stem cells.

Qin H, Yu T, Qing T, Liu Y, Zhao Y, Cai J, Li J, Song Z, Qu X, Zhou P, Wu J, Ding M, Deng H.

J Biol Chem. 2007 Feb 23;282(8):5842-52. Epub 2006 Dec 19.


p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression.

Novello C, Pazzaglia L, Conti A, Quattrini I, Pollino S, Perego P, Picci P, Benassi MS.

PLoS One. 2014 Dec 9;9(12):e114757. doi: 10.1371/journal.pone.0114757. eCollection 2014.


Regulation of p53 in embryonic stem cells.

Solozobova V, Blattner C.

Exp Cell Res. 2010 Sep 10;316(15):2434-46. doi: 10.1016/j.yexcr.2010.06.006. Epub 2010 Jun 11.


Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation.

Jung CJ, Iyengar S, Blahnik KR, Ajuha TP, Jiang JX, Farnham PJ, Zern M.

PLoS One. 2011;6(11):e27740. doi: 10.1371/journal.pone.0027740. Epub 2011 Nov 28.


miR-34 miRNAs provide a barrier for somatic cell reprogramming.

Choi YJ, Lin CP, Ho JJ, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks GG, Hannon GJ, He L.

Nat Cell Biol. 2011 Oct 23;13(11):1353-60. doi: 10.1038/ncb2366.


Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathway.

Yang A, Shi G, Zhou C, Lu R, Li H, Sun L, Jin Y.

J Biol Chem. 2011 Dec 16;286(50):43370-82. doi: 10.1074/jbc.M111.225185. Epub 2011 Oct 19.


The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation.

Liu FY, Tang XC, Deng M, Chen P, Ji W, Zhang X, Gong L, Woodward Z, Liu J, Zhang L, Sun S, Liu JP, Wu K, Wu MX, Liu XL, Yu MB, Liu Y, Li DW.

Curr Mol Med. 2012 Sep;12(8):917-28.


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