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Items: 1 to 20 of 90


Identifying functionally important conformational changes in proteins: activation of the yeast α-factor receptor Ste2p.

Taslimi A, Mathew E, Celić A, Wessel S, Dumont ME.

J Mol Biol. 2012 May 18;418(5):367-78. doi: 10.1016/j.jmb.2012.02.024. Epub 2012 Mar 3.


Identification of residues involved in homodimer formation located within a β-strand region of the N-terminus of a Yeast G protein-coupled receptor.

Uddin MS, Kim H, Deyo A, Naider F, Becker JM.

J Recept Signal Transduct Res. 2012 Apr;32(2):65-75. doi: 10.3109/10799893.2011.647352. Epub 2012 Jan 24.


Changes in conformation at the cytoplasmic ends of the fifth and sixth transmembrane helices of a yeast G protein-coupled receptor in response to ligand binding.

Umanah GK, Huang LY, Maccarone JM, Naider F, Becker JM.

Biochemistry. 2011 Aug 16;50(32):6841-54. doi: 10.1021/bi200254h. Epub 2011 Jul 12.


Cross-linking of a DOPA-containing peptide ligand into its G protein-coupled receptor.

Umanah GK, Son C, Ding F, Naider F, Becker JM.

Biochemistry. 2009 Mar 10;48(9):2033-44. doi: 10.1021/bi802061z.


Identification of amino acids at two dimer interface regions of the alpha-factor receptor (Ste2).

Wang HX, Konopka JB.

Biochemistry. 2009 Aug 4;48(30):7132-9. doi: 10.1021/bi900424h.


The first extracellular loop of the Saccharomyces cerevisiae G protein-coupled receptor Ste2p undergoes a conformational change upon ligand binding.

Hauser M, Kauffman S, Lee BK, Naider F, Becker JM.

J Biol Chem. 2007 Apr 6;282(14):10387-97. Epub 2007 Feb 9.


Multiple regulatory roles of the carboxy terminus of Ste2p a yeast GPCR.

Kim KM, Lee YH, Akal-Strader A, Uddin MS, Hauser M, Naider F, Becker JM.

Pharmacol Res. 2012 Jan;65(1):31-40. doi: 10.1016/j.phrs.2011.11.002. Epub 2011 Nov 10.


Interacting residues in an activated state of a G protein-coupled receptor.

Lee YH, Naider F, Becker JM.

J Biol Chem. 2006 Jan 27;281(4):2263-72. Epub 2005 Nov 28.


Novobiocin and peptide analogs of α-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p.

Rymer JK, Hauser M, Bourdon AK, Campagna SR, Naider F, Becker JM.

Biochim Biophys Acta. 2015 Apr;1848(4):916-24. doi: 10.1016/j.bbamem.2014.12.024. Epub 2015 Jan 7.


Quantification of mutation-derived bias for alternate mating functionalities of the Saccharomyces cerevisiae Ste2p pheromone receptor.

Choudhary P, Loewen MC.

J Biochem. 2016 Jan;159(1):49-58. doi: 10.1093/jb/mvv072. Epub 2015 Jul 30.


Functional and physical interactions among Saccharomyces cerevisiae α-factor receptors.

Gehret AU, Connelly SM, Dumont ME.

Eukaryot Cell. 2012 Oct;11(10):1276-88. doi: 10.1128/EC.00172-12. Epub 2012 Aug 24.


Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae.

Zuber J, Danial SA, Connelly SM, Naider F, Dumont ME.

Biochemistry. 2015 Mar 10;54(9):1787-806. doi: 10.1021/bi501314t. Epub 2015 Feb 24.


Expression and biophysical analysis of two double-transmembrane domain-containing fragments from a yeast G protein-coupled receptor.

Cohen LS, Arshava B, Estephan R, Englander J, Kim H, Hauser M, Zerbe O, Ceruso M, Becker JM, Naider F.

Biopolymers. 2008;90(2):117-30. doi: 10.1002/bip.20950.


The N-terminus of the yeast G protein-coupled receptor Ste2p plays critical roles in surface expression, signaling, and negative regulation.

Uddin MS, Hauser M, Naider F, Becker JM.

Biochim Biophys Acta. 2016 Apr;1858(4):715-24. doi: 10.1016/j.bbamem.2015.12.017. Epub 2015 Dec 17.


GPCR-Gα protein precoupling: Interaction between Ste2p, a yeast GPCR, and Gpa1p, its Gα protein, is formed before ligand binding via the Ste2p C-terminal domain and the Gpa1p N-terminal domain.

Cevheroğlu O, Becker JM, Son ÇD.

Biochim Biophys Acta. 2017 Dec;1859(12):2435-2446. doi: 10.1016/j.bbamem.2017.09.022. Epub 2017 Sep 27.


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