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Items: 1 to 20 of 101

1.

G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.

Nino G, Hu A, Grunstein JS, McDonough J, Kreiger PA, Josephson MB, Choi JK, Grunstein MM.

PLoS One. 2012;7(2):e32078. doi: 10.1371/journal.pone.0032078. Epub 2012 Feb 22.

2.

Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells.

Hu A, Diener BL, Josephson MB, Grunstein MM.

PLoS One. 2015 Mar 5;10(3):e0118712. doi: 10.1371/journal.pone.0118712. eCollection 2015.

3.

Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle.

Nino G, Hu A, Grunstein JS, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L746-57. doi: 10.1152/ajplung.00079.2009. Epub 2009 Aug 7.

4.

Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.

Hu A, Nino G, Grunstein JS, Fatma S, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1055-67. doi: 10.1152/ajplung.00021.2008. Epub 2008 Mar 21.

5.

Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.

Nino G, Hu A, Grunstein JS, Grunstein MM.

J Allergy Clin Immunol. 2010 May;125(5):1020-7. doi: 10.1016/j.jaci.2010.02.007. Epub 2010 Apr 14.

6.

Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling.

Shan X, Hu A, Veler H, Fatma S, Grunstein JS, Chuang S, Grunstein MM.

Am J Physiol Lung Cell Mol Physiol. 2006 Sep;291(3):L324-33. Epub 2006 Mar 31.

7.

Angiotensin II stimulates fibronectin protein synthesis via a Gβγ/arachidonic acid-dependent pathway.

Alexander LD, Ding Y, Alagarsamy S, Cui X.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F287-302. doi: 10.1152/ajprenal.00094.2014. Epub 2014 Jun 11.

8.

Smooth muscle CaMKIIδ promotes allergen-induced airway hyperresponsiveness and inflammation.

Spinelli AM, Liu Y, Sun LY, González-Cobos JC, Backs J, Trebak M, Singer HA.

Pflugers Arch. 2015 Dec;467(12):2541-54. doi: 10.1007/s00424-015-1713-5. Epub 2015 Jun 20.

10.

Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12.

Huang J, Nalli AD, Mahavadi S, Kumar DP, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2014 May 1;306(9):G802-10. doi: 10.1152/ajpgi.00440.2013. Epub 2014 Feb 27.

11.

Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle.

Hakonarson H, Maskeri N, Carter C, Chuang S, Grunstein MM.

J Clin Invest. 1999 Sep;104(5):657-67.

12.

Autocrine signaling by IL-10 mediates altered responsiveness of atopic sensitized airway smooth muscle.

Grunstein MM, Hakonarson H, Leiter J, Chen M, Whelan R, Grunstein JS, Chuang S.

Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1130-7.

13.

Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.

Takada E, Furuhata M, Nakae S, Ichijo H, Sudo K, Mizuguchi J.

Int Arch Allergy Immunol. 2013;162(2):104-14. doi: 10.1159/000353240. Epub 2013 Jul 31.

14.

Mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2-dependent pathways are essential for CD8+ T cell-mediated airway hyperresponsiveness and inflammation.

Ohnishi H, Takeda K, Domenico J, Lucas JJ, Miyahara N, Swasey CH, Dakhama A, Gelfand EW.

J Allergy Clin Immunol. 2009 Jan;123(1):249-57. doi: 10.1016/j.jaci.2008.10.054.

PMID:
19130938
16.
17.

Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation.

Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols HL, Abel M, Ionescu LI, Puttagunta L, Thebaud B, Gordon J, DeFea K, Hollenberg MD, Vliagoftis H.

Clin Exp Allergy. 2015 Dec;45(12):1844-55. doi: 10.1111/cea.12628.

PMID:
26312432
18.

Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma.

Deng YM, Xie QM, Tang HF, Sun JG, Deng JF, Chen JQ, Yang SY.

Eur J Pharmacol. 2006 Oct 10;547(1-3):125-35. Epub 2006 Jul 13.

PMID:
16956605
19.

Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of G{alpha}i3.

Flynn RS, Mahavadi S, Murthy KS, Kellum JM, Kuemmerle JF.

Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1232-8. doi: 10.1152/ajpgi.00323.2009. Epub 2009 Oct 1.

20.

Effects of (±)-praeruptorin A on airway inflammation, airway hyperresponsiveness and NF-κB signaling pathway in a mouse model of allergic airway disease.

Xiong Y, Wang J, Wu F, Li J, Zhou L, Kong L.

Eur J Pharmacol. 2012 May 15;683(1-3):316-24. doi: 10.1016/j.ejphar.2012.03.004. Epub 2012 Mar 15.

PMID:
22449378

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