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Wip1-dependent signaling pathways in health and diseases.

Zhu YH, Bulavin DV.

Prog Mol Biol Transl Sci. 2012;106:307-25. doi: 10.1016/B978-0-12-396456-4.00001-8. Review.


Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.

Yoda A, Toyoshima K, Watanabe Y, Onishi N, Hazaka Y, Tsukuda Y, Tsukada J, Kondo T, Tanaka Y, Minami Y.

J Biol Chem. 2008 Jul 4;283(27):18969-79. doi: 10.1074/jbc.M800560200. Epub 2008 May 15.


Wip1 phosphatase modulates ATM-dependent signaling pathways.

Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, Timofeev ON, Dudgeon C, Fornace AJ, Anderson CW, Minami Y, Appella E, Bulavin DV.

Mol Cell. 2006 Sep 1;23(5):757-64.


Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.

Darlington Y, Nguyen TA, Moon SH, Herron A, Rao P, Zhu C, Lu X, Donehower LA.

Oncogene. 2012 Mar 1;31(9):1155-65. doi: 10.1038/onc.2011.303. Epub 2011 Jul 18.


Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.

Lu X, Nguyen TA, Donehower LA.

Cell Cycle. 2005 Aug;4(8):1060-4. Epub 2005 Aug 26.


Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.

Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ Jr, Anderson CW, Appella E, Bulavin DV.

J Exp Med. 2006 Dec 25;203(13):2793-9. Epub 2006 Dec 11.


The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases.

Yamaguchi H, Durell SR, Chatterjee DK, Anderson CW, Appella E.

Biochemistry. 2007 Nov 6;46(44):12594-603. Epub 2007 Oct 16.


Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.

Schito ML, Demidov ON, Saito S, Ashwell JD, Appella E.

J Immunol. 2006 Apr 15;176(8):4818-25.


WIP1 phosphatase at the crossroads of cancer and aging.

Le Guezennec X, Bulavin DV.

Trends Biochem Sci. 2010 Feb;35(2):109-14. doi: 10.1016/j.tibs.2009.09.005. Epub 2009 Oct 29. Review.


Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.

Demidov ON, Zhu Y, Kek C, Goloudina AR, Motoyama N, Bulavin DV.

Cell Death Differ. 2012 Nov;19(11):1761-8. doi: 10.1038/cdd.2012.57. Epub 2012 May 4.


Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.

Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA.

J Biol Chem. 2010 Apr 23;285(17):12935-47. doi: 10.1074/jbc.M109.071696. Epub 2010 Jan 29.


The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

Demidov ON, Kek C, Shreeram S, Timofeev O, Fornace AJ, Appella E, Bulavin DV.

Oncogene. 2007 Apr 12;26(17):2502-6. Epub 2006 Oct 2.


The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

Lu X, Nguyen TA, Moon SH, Darlington Y, Sommer M, Donehower LA.

Cancer Metastasis Rev. 2008 Jun;27(2):123-35. doi: 10.1007/s10555-008-9127-x. Review.


The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression.

Han HS, Yu E, Song JY, Park JY, Jang SJ, Choi J.

Mol Cancer Res. 2009 May;7(5):713-23. doi: 10.1158/1541-7786.MCR-08-0247. Epub 2009 May 12.


Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers.

Yu E, Ahn YS, Jang SJ, Kim MJ, Yoon HS, Gong G, Choi J.

Breast Cancer Res Treat. 2007 Mar;101(3):269-78. Epub 2006 Aug 9.


The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.

Oliva-Trastoy M, Berthonaud V, Chevalier A, Ducrot C, Marsolier-Kergoat MC, Mann C, Leteurtre F.

Oncogene. 2007 Mar 1;26(10):1449-58. Epub 2006 Aug 28.


The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA.

Cancer Cell. 2007 Oct;12(4):342-54.


Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.

Song JY, Han HS, Sabapathy K, Lee BM, Yu E, Choi J.

J Biol Chem. 2010 Mar 19;285(12):9067-76. doi: 10.1074/jbc.M109.070003. Epub 2010 Jan 21.


Wip1-dependent regulation of autophagy, obesity, and atherosclerosis.

Le Guezennec X, Brichkina A, Huang YF, Kostromina E, Han W, Bulavin DV.

Cell Metab. 2012 Jul 3;16(1):68-80. doi: 10.1016/j.cmet.2012.06.003.


Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis.

Xia Y, Ongusaha P, Lee SW, Liou YC.

J Biol Chem. 2009 Jun 26;284(26):17428-37. doi: 10.1074/jbc.M109.007823. Epub 2009 Apr 24.

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