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Items: 1 to 20 of 146

1.

The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription.

Mak AB, Nixon AM, Moffat J.

Cancer Res. 2012 Apr 15;72(8):1929-34. doi: 10.1158/0008-5472.CAN-11-3589. Epub 2012 Feb 14.

2.

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3.

Ahmad K, Scholz B, Capelo R, Schweighöfer I, Kahnt AS, Marschalek R, Steinhilber D.

Oncotarget. 2015 Sep 22;6(28):25784-800. doi: 10.18632/oncotarget.4703.

3.

The heterodimerization domains of MLL-FYRN and FYRC--are potential target structures in t(4;11) leukemia.

Pless B, Oehm C, Knauer S, Stauber RH, Dingermann T, Marschalek R.

Leukemia. 2011 Apr;25(4):663-70. doi: 10.1038/leu.2010.308. Epub 2011 Jan 14.

PMID:
21233834
4.

t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL.

Kumar AR, Yao Q, Li Q, Sam TA, Kersey JH.

Leuk Res. 2011 Mar;35(3):305-9. doi: 10.1016/j.leukres.2010.08.011. Epub 2010 Sep 25.

5.

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

Bursen A, Schwabe K, Rüster B, Henschler R, Ruthardt M, Dingermann T, Marschalek R.

Blood. 2010 Apr 29;115(17):3570-9. doi: 10.1182/blood-2009-06-229542. Epub 2010 Mar 1.

6.

MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment.

Ugale A, Säwén P, Dudenhöffer-Pfeifer M, Wahlestedt M, Norddahl GL, Bryder D.

Oncogene. 2017 Jun 1;36(22):3207-3212. doi: 10.1038/onc.2016.470. Epub 2017 Jan 9.

PMID:
28068328
7.

AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription.

Okuda H, Kanai A, Ito S, Matsui H, Yokoyama A.

Nat Commun. 2015 Nov 23;6:8869. doi: 10.1038/ncomms9869.

8.

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

Gessner A, Thomas M, Castro PG, Büchler L, Scholz A, Brümmendorf TH, Soria NM, Vormoor J, Greil J, Heidenreich O.

Leukemia. 2010 Oct;24(10):1751-9. doi: 10.1038/leu.2010.155. Epub 2010 Aug 5.

PMID:
20686504
9.

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.

Biswas D, Milne TA, Basrur V, Kim J, Elenitoba-Johnson KS, Allis CD, Roeder RG.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15751-6. doi: 10.1073/pnas.1111498108. Epub 2011 Sep 6.

10.

Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O.

Blood. 2005 Nov 15;106(10):3559-66. Epub 2005 Jul 26.

11.

Molecular characterization of a rare MLL-AF4 (MLL-AFF1) fusion rearrangement in infant leukemia.

Bizarro S, Cerveira N, Correia C, Lisboa S, Peixoto A, Norton L, Teixeira MR.

Cancer Genet Cytogenet. 2007 Oct 1;178(1):61-4.

PMID:
17889710
12.
13.

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.

Lin S, Luo RT, Ptasinska A, Kerry J, Assi SA, Wunderlich M, Imamura T, Kaberlein JJ, Rayes A, Althoff MJ, Anastasi J, O'Brien MM, Meetei AR, Milne TA, Bonifer C, Mulloy JC, Thirman MJ.

Cancer Cell. 2016 Nov 14;30(5):737-749. doi: 10.1016/j.ccell.2016.10.008.

14.

Estradiol induces gene proximity and MLL-MLLT3 fusion in an activation-induced cytidine deaminase-mediated pathway.

Wright RL, Slemmons KK, Vaughan AT.

Leuk Lymphoma. 2015 May;56(5):1460-5. doi: 10.3109/10428194.2014.954112. Epub 2014 Nov 25.

PMID:
25130479
15.

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia.

Sanjuan-Pla A, Bueno C, Prieto C, Acha P, Stam RW, Marschalek R, Menéndez P.

Blood. 2015 Dec 17;126(25):2676-85. doi: 10.1182/blood-2015-09-667378. Epub 2015 Oct 13. Review.

16.

Frat2 mediates the oncogenic activation of Rac by MLL fusions.

Walf-Vorderwülbecke V, de Boer J, Horton SJ, van Amerongen R, Proost N, Berns A, Williams O.

Blood. 2012 Dec 6;120(24):4819-28. doi: 10.1182/blood-2012-05-432534. Epub 2012 Oct 16.

17.

MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.

Monroe SC, Jo SY, Sanders DS, Basrur V, Elenitoba-Johnson KS, Slany RK, Hess JL.

Exp Hematol. 2011 Jan;39(1):77-86.e1-5. doi: 10.1016/j.exphem.2010.09.003. Epub 2010 Sep 18.

18.

The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.

Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14028-33. Epub 2005 Sep 16.

19.

The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.

Osaki H, Walf-Vorderwülbecke V, Mangolini M, Zhao L, Horton SJ, Morrone G, Schuringa JJ, de Boer J, Williams O.

Leukemia. 2013 Jul;27(7):1461-8. doi: 10.1038/leu.2013.42. Epub 2013 Feb 13.

PMID:
23403462
20.

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