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Items: 1 to 20 of 89

1.

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Mat├ęs JM, Alonso FJ, Wang C, Seo Y, Chen X, Bishop JM.

Cell Metab. 2012 Feb 8;15(2):157-70. doi: 10.1016/j.cmet.2011.12.015.

2.

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2.

Xiao D, Ren P, Su H, Yue M, Xiu R, Hu Y, Liu H, Qing G.

Oncotarget. 2015 Dec 1;6(38):40655-66. doi: 10.18632/oncotarget.5821.

3.

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.

Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ.

Cancer Res. 2009 Oct 15;69(20):7986-93. doi: 10.1158/0008-5472.CAN-09-2266. Epub 2009 Oct 13. Erratum in: Cancer Res. 2010 Feb 1;70(3):1275. Bachoo, Robert G [corrected to Bachoo, Robert M].

4.

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction.

Fogal V, Babic I, Chao Y, Pastorino S, Mukthavaram R, Jiang P, Cho YJ, Pingle SC, Crawford JR, Piccioni DE, Kesari S.

Oncotarget. 2015 Jan 20;6(2):1157-70.

5.

Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.

Dang CV.

Cancer Res. 2010 Feb 1;70(3):859-62. doi: 10.1158/0008-5472.CAN-09-3556. Epub 2010 Jan 19. Review.

6.

MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.

Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A.

EMBO Rep. 2017 Apr;18(4):569-585. doi: 10.15252/embr.201643068. Epub 2017 Feb 20.

PMID:
28219903
7.

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.

Bott AJ, Peng IC, Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokowski D, Lu W, Pan JA, Powers S, Rabinowitz J, Hatzoglou M, Murphy DJ, Jones R, Wu S, Girnun G, Zong WX.

Cell Metab. 2015 Dec 1;22(6):1068-77. doi: 10.1016/j.cmet.2015.09.025. Epub 2015 Oct 23.

8.

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.

Jeong SM, Lee A, Lee J, Haigis MC.

J Biol Chem. 2014 Feb 14;289(7):4135-44. doi: 10.1074/jbc.M113.525949. Epub 2013 Dec 24.

9.
10.

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18782-7. doi: 10.1073/pnas.0810199105. Epub 2008 Nov 24.

11.

Synergy between truncated c-Met (cyto-Met) and c-Myc in liver oncogenesis: importance of TGF-beta signalling in the control of liver homeostasis and transformation.

Amicone L, Terradillos O, Calvo L, Costabile B, Cicchini C, Della Rocca C, Lozupone F, Piacentini M, Buendia MA, Tripodi M.

Oncogene. 2002 Feb 21;21(9):1335-45.

12.

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.

Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV.

Nature. 2009 Apr 9;458(7239):762-5. doi: 10.1038/nature07823. Epub 2009 Feb 15.

13.

The molecular determinants of de novo nucleotide biosynthesis in cancer cells.

Tong X, Zhao F, Thompson CB.

Curr Opin Genet Dev. 2009 Feb;19(1):32-7. doi: 10.1016/j.gde.2009.01.002. Epub 2009 Feb 5. Review.

14.

Therapeutic targeting of Myc-reprogrammed cancer cell metabolism.

Dang CV.

Cold Spring Harb Symp Quant Biol. 2011;76:369-74. doi: 10.1101/sqb.2011.76.011296. Epub 2011 Sep 29. Review.

PMID:
21960526
15.

MYC-induced cancer cell energy metabolism and therapeutic opportunities.

Dang CV, Le A, Gao P.

Clin Cancer Res. 2009 Nov 1;15(21):6479-83. doi: 10.1158/1078-0432.CCR-09-0889. Epub 2009 Oct 27. Review.

16.

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.

Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR.

Nat Commun. 2015 Nov 12;6:8873. doi: 10.1038/ncomms9873.

17.

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.

Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV.

Cell Metab. 2012 Jan 4;15(1):110-21. doi: 10.1016/j.cmet.2011.12.009.

18.

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW, Phang JM.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8983-8. doi: 10.1073/pnas.1203244109. Epub 2012 May 21.

19.

Studying Myc's role in metabolism regulation.

Le A, Dang CV.

Methods Mol Biol. 2013;1012:213-9. doi: 10.1007/978-1-62703-429-6_14.

20.

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition.

Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Maciel TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D.

Blood. 2015 Sep 10;126(11):1346-56. doi: 10.1182/blood-2015-01-621870. Epub 2015 Jul 17.

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