Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 80

1.

3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.

Annedi SC, Maddaford SP, Ramnauth J, Renton P, Speed J, Rakhit S, Andrews JS, Porreca F.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1980-4. doi: 10.1016/j.bmcl.2012.01.031. Epub 2012 Jan 21.

PMID:
22318159
2.

Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.

Annedi SC, Maddaford SP, Mladenova G, Ramnauth J, Rakhit S, Andrews JS, Lee DK, Zhang D, Porreca F, Bunton D, Christie L.

J Med Chem. 2011 Oct 27;54(20):7408-16. doi: 10.1021/jm201063u. Epub 2011 Oct 5.

PMID:
21923116
3.

1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.

Renton P, Speed J, Maddaford S, Annedi SC, Ramnauth J, Rakhit S, Andrews J.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5301-4. doi: 10.1016/j.bmcl.2011.07.022. Epub 2011 Jul 14.

PMID:
21813276
4.

Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).

Annedi SC, Ramnauth J, Cossette M, Maddaford SP, Dove P, Rakhit S, Andrews JS, Porreca F.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2510-3. doi: 10.1016/j.bmcl.2012.02.004. Epub 2012 Feb 9.

PMID:
22370270
5.

Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.

Annedi SC, Ramnauth J, Maddaford SP, Renton P, Rakhit S, Mladenova G, Dove P, Silverman S, Andrews JS, Felice MD, Porreca F.

J Med Chem. 2012 Jan 26;55(2):943-55. doi: 10.1021/jm201564u. Epub 2012 Jan 10.

PMID:
22175766
6.

First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.

Mladenova G, Annedi SC, Ramnauth J, Maddaford SP, Rakhit S, Andrews JS, Zhang D, Porreca F.

J Med Chem. 2012 Apr 12;55(7):3488-501. doi: 10.1021/jm300138g. Epub 2012 Apr 4.

PMID:
22420844
7.

Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, Porreca F.

J Med Chem. 2011 Aug 11;54(15):5562-75. doi: 10.1021/jm200648s. Epub 2011 Jul 8.

9.

1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.

Maddaford S, Renton P, Speed J, Annedi SC, Ramnauth J, Rakhit S, Andrews J, Mladenova G, Majuta L, Porreca F.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5234-8. doi: 10.1016/j.bmcl.2011.07.042. Epub 2011 Jul 22.

10.

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.

Hah JM, Martásek P, Roman LJ, Silverman RB.

J Med Chem. 2003 Apr 24;46(9):1661-9.

PMID:
12699384
11.

Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice.

Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H.

Neuropharmacology. 2009 Mar;56(3):702-8. doi: 10.1016/j.neuropharm.2008.12.003. Epub 2008 Dec 16.

PMID:
19111753
12.

Role of neuronal nitric oxide synthase in the antiallodynic effects of intrathecal EGCG in a neuropathic pain rat model.

Choi JI, Kim WM, Lee HG, Kim YO, Yoon MH.

Neurosci Lett. 2012 Feb 21;510(1):53-7. doi: 10.1016/j.neulet.2011.12.070. Epub 2012 Jan 10.

PMID:
22249118
13.

Nitric oxide synthase isoform inhibition before whole body ischemia reperfusion in pigs: vital or protective?

Adams JA, Wu D, Bassuk J, Arias J, Lozano H, Kurlansky P, Lamas GA.

Resuscitation. 2007 Sep;74(3):516-25. Epub 2007 Apr 26.

PMID:
17466432
14.

Novel inhibitors of nitric oxide synthase with antioxidant properties.

Salerno L, Modica MN, Romeo G, Pittalà V, Siracusa MA, Amato ME, Acquaviva R, Di Giacomo C, Sorrenti V.

Eur J Med Chem. 2012 Mar;49:118-26. doi: 10.1016/j.ejmech.2012.01.002. Epub 2012 Jan 11.

PMID:
22280820
15.

Involvement of neuronal, inducible and endothelial nitric oxide synthases in capsaicin-induced muscle hypersensitivity.

Lee JS, Zhang Y, Ro JY.

Eur J Pain. 2009 Oct;13(9):924-8. doi: 10.1016/j.ejpain.2008.11.009. Epub 2008 Dec 11.

PMID:
19084437
16.

Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.

Annedi SC, Maddaford SP, Ramnauth J, Renton P, Rybak T, Silverman S, Rakhit S, Mladenova G, Dove P, Andrews JS, Zhang D, Porreca F.

Eur J Med Chem. 2012 Sep;55:94-107. doi: 10.1016/j.ejmech.2012.07.006. Epub 2012 Jul 14.

PMID:
22840695
17.

Role of neuronal nitric-oxide synthase in estrogen-induced relaxation in rat resistance arteries.

Lekontseva O, Chakrabarti S, Jiang Y, Cheung CC, Davidge ST.

J Pharmacol Exp Ther. 2011 Nov;339(2):367-75. doi: 10.1124/jpet.111.183798. Epub 2011 Aug 1.

18.

Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.

Chu YC, Guan Y, Skinner J, Raja SN, Johns RA, Tao YX.

Pain. 2005 Dec 15;119(1-3):113-23. Epub 2005 Nov 16.

PMID:
16297560
20.

Neuronal nitric oxide synthase-derived hydrogen peroxide is a major endothelium-dependent relaxing factor.

Capettini LS, Cortes SF, Gomes MA, Silva GA, Pesquero JL, Lopes MJ, Teixeira MM, Lemos VS.

Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2503-11. doi: 10.1152/ajpheart.00731.2008. Epub 2008 Oct 24.

PMID:
18952716

Supplemental Content

Support Center