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Items: 1 to 20 of 134


Trans-synaptic spread of tau pathology in vivo.

Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K.

PLoS One. 2012;7(2):e31302. doi: 10.1371/journal.pone.0031302. Epub 2012 Feb 1.


Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.

Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L.

PLoS One. 2012;7(9):e45881. doi: 10.1371/journal.pone.0045881. Epub 2012 Sep 24.


The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy.

Siman R, Cocca R, Dong Y.

PLoS One. 2015 Nov 5;10(11):e0142340. doi: 10.1371/journal.pone.0142340. eCollection 2015.


A rapid gene delivery-based mouse model for early-stage Alzheimer disease-type tauopathy.

Siman R, Lin YG, Malthankar-Phatak G, Dong Y.

J Neuropathol Exp Neurol. 2013 Nov;72(11):1062-71. doi: 10.1097/NEN.0000000000000006.


Propagation of tau pathology in a model of early Alzheimer's disease.

de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT.

Neuron. 2012 Feb 23;73(4):685-97. doi: 10.1016/j.neuron.2011.11.033. Erratum in: Neuron. 2012 Oct 18;76(2):461.


Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections.

Iba M, McBride JD, Guo JL, Zhang B, Trojanowski JQ, Lee VM.

Acta Neuropathol. 2015 Sep;130(3):349-62. doi: 10.1007/s00401-015-1458-4. Epub 2015 Jul 7.


Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.

Maurin H, Chong SA, Kraev I, Davies H, Kremer A, Seymour CM, Lechat B, Jaworski T, Borghgraef P, Devijver H, Callewaert G, Stewart MG, Van Leuven F.

PLoS One. 2014 Feb 3;9(2):e87605. doi: 10.1371/journal.pone.0087605. eCollection 2014.


Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.

Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D.

Cell Rep. 2015 May 26;11(8):1176-83. doi: 10.1016/j.celrep.2015.04.043. Epub 2015 May 14.


A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.

Ahmed Z, Cooper J, Murray TK, Garn K, McNaughton E, Clarke H, Parhizkar S, Ward MA, Cavallini A, Jackson S, Bose S, Clavaguera F, Tolnay M, Lavenir I, Goedert M, Hutton ML, O'Neill MJ.

Acta Neuropathol. 2014 May;127(5):667-83. doi: 10.1007/s00401-014-1254-6. Epub 2014 Feb 16.


A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.

Rockenstein E, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Bisquert A, Trejo-Morales M, Spencer B, Masliah E.

PLoS One. 2015 Mar 24;10(3):e0121570. doi: 10.1371/journal.pone.0121570. eCollection 2015.


Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer's disease.

Shao CY, Mirra SS, Sait HB, Sacktor TC, Sigurdsson EM.

Acta Neuropathol. 2011 Sep;122(3):285-92. doi: 10.1007/s00401-011-0843-x. Epub 2011 Jun 1.


Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains.

Boluda S, Iba M, Zhang B, Raible KM, Lee VM, Trojanowski JQ.

Acta Neuropathol. 2015 Feb;129(2):221-37. doi: 10.1007/s00401-014-1373-0. Epub 2014 Dec 24.


Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.

Stancu IC, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D, Dewachter I.

Acta Neuropathol. 2015 Jun;129(6):875-94. doi: 10.1007/s00401-015-1413-4. Epub 2015 Apr 11.


Depletion of microglia and inhibition of exosome synthesis halt tau propagation.

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T.

Nat Neurosci. 2015 Nov;18(11):1584-93. doi: 10.1038/nn.4132. Epub 2015 Oct 5.


Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.

Giannopoulos PF, Chu J, Sperow M, Li JG, Yu WH, Kirby LG, Abood M, Praticò D.

Biol Psychiatry. 2015 Nov 15;78(10):693-701. doi: 10.1016/j.biopsych.2015.01.015. Epub 2015 Feb 7.


Argyrophilic grain pathology as a natural model of tau propagation.

Rábano A, Rodal I, Cuadros R, Calero M, Hernández F, Ávila J.

J Alzheimers Dis. 2014;40 Suppl 1:S123-33. doi: 10.3233/JAD-132288.


A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E, Segal M, Ginzburg I, Abramsky O.

Exp Neurol. 2008 Jul;212(1):71-84. doi: 10.1016/j.expneurol.2008.03.007. Epub 2008 Mar 21.


Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.

Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.

Acta Neuropathol. 2014 May;127(5):685-98. doi: 10.1007/s00401-014-1259-1. Epub 2014 Feb 15.


Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.

Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M, Buée L.

Acta Neuropathol Commun. 2014 Jan 30;2:14. doi: 10.1186/2051-5960-2-14.


Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.

Dalby NO, Volbracht C, Helboe L, Larsen PH, Jensen HS, Egebjerg J, Elvang AB.

J Alzheimers Dis. 2014;40(2):429-42. doi: 10.3233/JAD-131358.


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