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Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity.

Malley R, Anderson PW.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3623-7. doi: 10.1073/pnas.1121383109. Epub 2012 Feb 2. Review.


Protection against Pneumococcal colonization and fatal pneumonia by a trivalent conjugate of a fusion protein with the cell wall polysaccharide.

Lu YJ, Forte S, Thompson CM, Anderson PW, Malley R.

Infect Immun. 2009 May;77(5):2076-83. doi: 10.1128/IAI.01554-08. Epub 2009 Mar 2.


Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide.

Malley R, Srivastava A, Lipsitch M, Thompson CM, Watkins C, Tzianabos A, Anderson PW.

Infect Immun. 2006 Apr;74(4):2187-95.


Intranasal vaccination with γ-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses.

Babb R, Chen A, Hirst TR, Kara EE, McColl SR, Ogunniyi AD, Paton JC, Alsharifi M.

Clin Sci (Lond). 2016 May;130(9):697-710. doi: 10.1042/CS20150699. Epub 2016 Feb 1.


Options for inactivation, adjuvant, and route of topical administration of a killed, unencapsulated pneumococcal whole-cell vaccine.

Lu YJ, Yadav P, Clements JD, Forte S, Srivastava A, Thompson CM, Seid R, Look J, Alderson M, Tate A, Maisonneuve JF, Robertson G, Anderson PW, Malley R.

Clin Vaccine Immunol. 2010 Jun;17(6):1005-12. doi: 10.1128/CVI.00036-10. Epub 2010 Apr 28.


Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses.

Wilson R, Cohen JM, Jose RJ, de Vogel C, Baxendale H, Brown JS.

Mucosal Immunol. 2015 May;8(3):627-39. doi: 10.1038/mi.2014.95. Epub 2014 Oct 29.


Mechanisms in the serotype-independent pneumococcal immunity induced in mice by intranasal vaccination with the cell wall polysaccharide.

Lu YJ, Skovsted IC, Thompson CM, Anderson PW, Malley R.

Microb Pathog. 2009 Sep;47(3):177-82. doi: 10.1016/j.micpath.2009.06.008. Epub 2009 Jul 3.


Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine.

Moffitt KL, Yadav P, Weinberger DM, Anderson PW, Malley R.

Vaccine. 2012 Jun 19;30(29):4316-22. doi: 10.1016/j.vaccine.2012.01.034.


Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model.

Bogaert D, Weinberger D, Thompson C, Lipsitch M, Malley R.

Infect Immun. 2009 Apr;77(4):1613-22. doi: 10.1128/IAI.00871-08. Epub 2009 Jan 21.


Mucosal and systemic immunization with a novel attenuated pneumococcal vaccine candidate confer serotype independent protection against Streptococcus pneumoniae in mice.

Wu K, Yao R, Wang H, Pang D, Liu Y, Xu H, Zhang S, Zhang X, Yin Y.

Vaccine. 2014 Jul 16;32(33):4179-88. doi: 10.1016/j.vaccine.2014.05.019. Epub 2014 Jun 2.


Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development.

Malley R.

J Mol Med (Berl). 2010 Feb;88(2):135-42. doi: 10.1007/s00109-009-0579-4. Epub 2010 Jan 5. Review.


Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species.

Pletz MW, Maus U, Krug N, Welte T, Lode H.

Int J Antimicrob Agents. 2008 Sep;32(3):199-206. doi: 10.1016/j.ijantimicag.2008.01.021. Epub 2008 Apr 18. Review.


Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells.

Trzciński K, Thompson CM, Srivastava A, Basset A, Malley R, Lipsitch M.

Infect Immun. 2008 Jun;76(6):2678-84. doi: 10.1128/IAI.00141-08. Epub 2008 Apr 7.


CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization.

Malley R, Trzcinski K, Srivastava A, Thompson CM, Anderson PW, Lipsitch M.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4848-53. Epub 2005 Mar 21.


The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.

Richards L, Ferreira DM, Miyaji EN, Andrew PW, Kadioglu A.

Immunobiology. 2010 Apr;215(4):251-63. doi: 10.1016/j.imbio.2009.12.004. Epub 2009 Dec 28.


Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae.

Li Y, Gierahn T, Thompson CM, Trzciński K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M.

PLoS Pathog. 2012;8(11):e1002989. doi: 10.1371/journal.ppat.1002989. Epub 2012 Nov 8.


Pneumococcal conjugate vaccine for young children.

Selman S, Hayes D, Perin LA, Hayes WS.

Manag Care. 2000 Sep;9(9):49-52, 54, 56-7 passim. Review.


Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine.

Moffitt KL, Malley R, Lu YJ.

PLoS One. 2012;7(8):e43445. doi: 10.1371/journal.pone.0043445. Epub 2012 Aug 14.


Interleukin-17A mediates acquired immunity to pneumococcal colonization.

Lu YJ, Gross J, Bogaert D, Finn A, Bagrade L, Zhang Q, Kolls JK, Srivastava A, Lundgren A, Forte S, Thompson CM, Harney KF, Anderson PW, Lipsitch M, Malley R.

PLoS Pathog. 2008 Sep 19;4(9):e1000159. doi: 10.1371/journal.ppat.1000159.


Mucosal immunization with recombinant fusion protein DnaJ-ΔA146Ply enhances cross-protective immunity against Streptococcus pneumoniae infection in mice via interleukin 17A.

Liu Y, Wang H, Zhang S, Zeng L, Xu X, Wu K, Wang W, Yin N, Song Z, Zhang X, Yin Y.

Infect Immun. 2014 Apr;82(4):1666-75. doi: 10.1128/IAI.01391-13. Epub 2014 Feb 3.

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