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Items: 1 to 20 of 108

1.

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.

Khare SD, Kipnis Y, Greisen P Jr, Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H, Sussman JL, Stoddard BL, Tawfik DS, Baker D.

Nat Chem Biol. 2012 Feb 5;8(3):294-300. doi: 10.1038/nchembio.777.

2.

Protein design: A metalloenzyme reloaded.

Höcker B.

Nat Chem Biol. 2012 Feb 15;8(3):224-5. doi: 10.1038/nchembio.800. No abstract available.

PMID:
22337091
3.

Simulating the catalytic effect of a designed mononuclear zinc metalloenzyme that catalyzes the hydrolysis of phosphate triesters.

Singh MK, Chu ZT, Warshel A.

J Phys Chem B. 2014 Oct 23;118(42):12146-52. doi: 10.1021/jp507592g. Epub 2014 Oct 13.

4.

Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering.

Der BS, Edwards DR, Kuhlman B.

Biochemistry. 2012 May 8;51(18):3933-40. doi: 10.1021/bi201881p. Epub 2012 Apr 24.

5.

Crystallographic observation of a trapped tetrahedral intermediate in a metalloenzyme.

Wilson DK, Quiocho FA.

Nat Struct Biol. 1994 Oct;1(10):691-4.

PMID:
7634072
6.

Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.

Tsai PC, Fox N, Bigley AN, Harvey SP, Barondeau DP, Raushel FM.

Biochemistry. 2012 Aug 14;51(32):6463-75. Epub 2012 Jul 31.

7.

Catalytic zinc site and mechanism of the metalloenzyme PR-AMP cyclohydrolase.

D'Ordine RL, Linger RS, Thai CJ, Davisson VJ.

Biochemistry. 2012 Jul 24;51(29):5791-803. doi: 10.1021/bi300391m. Epub 2012 Jul 9.

8.

Computational redesign of metalloenzymes for catalyzing new reactions.

Greisen P Jr, Khare SD.

Methods Mol Biol. 2014;1216:265-73. doi: 10.1007/978-1-4939-1486-9_14. Review.

PMID:
25213421
9.

Design of a zinc-finger hydrolase with a synthetic αββ protein.

Srivastava KR, Durani S.

PLoS One. 2014 May 9;9(5):e96234. doi: 10.1371/journal.pone.0096234. eCollection 2014.

10.

Site-directed mutagenesis maps interactions that enhance cognate and limit promiscuous catalysis by an alkaline phosphatase superfamily phosphodiesterase.

Wiersma-Koch H, Sunden F, Herschlag D.

Biochemistry. 2013 Dec 23;52(51):9167-76. doi: 10.1021/bi4010045. Epub 2013 Dec 11.

11.

Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.

Chu Y, Williams NH, Hengge AC.

Biochemistry. 2017 Aug 1;56(30):3923-3933. doi: 10.1021/acs.biochem.7b00441. Epub 2017 Jul 21.

PMID:
28678475
12.

Site-directed mutagenesis of active site glutamate-217 in mouse adenosine deaminase.

Mohamedali KA, Kurz LC, Rudolph FB.

Biochemistry. 1996 Feb 6;35(5):1672-80.

PMID:
8634299
14.

Identification of human butyrylcholinesterase organophosphate-resistant variants through a novel mammalian enzyme functional screen.

Zhang J, Chen S, Ralph EC, Dwyer M, Cashman JR.

J Pharmacol Exp Ther. 2012 Dec;343(3):673-82. doi: 10.1124/jpet.112.198499. Epub 2012 Sep 6.

15.

The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis.

Ely F, Hadler KS, Gahan LR, Guddat LW, Ollis DL, Schenk G.

Biochem J. 2010 Dec 15;432(3):565-73. doi: 10.1042/BJ20101054.

PMID:
20868365
16.

Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter.

Ely F, Pedroso MM, Gahan LR, Ollis DL, Guddat LW, Schenk G.

J Inorg Biochem. 2012 Jan;106(1):19-22. doi: 10.1016/j.jinorgbio.2011.09.015. Epub 2011 Sep 17.

PMID:
22112835
17.

A designed supramolecular protein assembly with in vivo enzymatic activity.

Song WJ, Tezcan FA.

Science. 2014 Dec 19;346(6216):1525-8. doi: 10.1126/science.1259680.

PMID:
25525249
18.

Engineering a zinc binding site into the de novo designed protein DS119 with a βαβ structure.

Zhu C, Zhang C, Liang H, Lai L.

Protein Cell. 2011 Dec;2(12):1006-13. doi: 10.1007/s13238-011-1121-3. Epub 2012 Jan 10.

19.

Detoxification of organophosphate nerve agents by bacterial phosphotriesterase.

Ghanem E, Raushel FM.

Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):459-70. Review.

PMID:
15982683
20.

ADAR proteins: structure and catalytic mechanism.

Goodman RA, Macbeth MR, Beal PA.

Curr Top Microbiol Immunol. 2012;353:1-33. doi: 10.1007/82_2011_144. Review.

PMID:
21769729

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