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Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo.

Berens TJ, Toczyski DP.

Mol Biol Cell. 2012 Mar;23(6):1058-67. doi: 10.1091/mbc.E11-10-0852. Epub 2012 Feb 1.


Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1.

Chen SH, Zhou H.

J Biol Chem. 2009 Jul 10;284(28):18593-604. doi: 10.1074/jbc.M109.018242. Epub 2009 May 19.


Requirement of replication checkpoint protein kinases Mec1/Rad53 for postreplication repair in yeast.

Gangavarapu V, Santa Maria SR, Prakash S, Prakash L.

MBio. 2011 May 17;2(3):e00079-11. doi: 10.1128/mBio.00079-11. Print 2011.


Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.

Bandhu A, Kang J, Fukunaga K, Goto G, Sugimoto K.

PLoS Genet. 2014 Feb 20;10(2):e1004136. doi: 10.1371/journal.pgen.1004136. eCollection 2014 Feb.


Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork.

Naylor ML, Li JM, Osborn AJ, Elledge SJ.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12765-70. doi: 10.1073/pnas.0904623106. Epub 2009 Jun 10.


The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.

Navadgi-Patil VM, Kumar S, Burgers PM.

J Biol Chem. 2011 Nov 25;286(47):40999-1007. doi: 10.1074/jbc.M111.283994. Epub 2011 Sep 28.


A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae.

Janke R, Herzberg K, Rolfsmeier M, Mar J, Bashkirov VI, Haghnazari E, Cantin G, Yates JR 3rd, Heyer WD.

Nucleic Acids Res. 2010 Apr;38(7):2302-13. doi: 10.1093/nar/gkp1222. Epub 2010 Jan 8.


Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

Hustedt N, Seeber A, Sack R, Tsai-Pflugfelder M, Bhullar B, Vlaming H, van Leeuwen F, Guénolé A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM.

Mol Cell. 2015 Jan 22;57(2):273-89. doi: 10.1016/j.molcel.2014.11.016. Epub 2014 Dec 18.


The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint.

Majka J, Niedziela-Majka A, Burgers PM.

Mol Cell. 2006 Dec 28;24(6):891-901.


CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.

Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP.

PLoS Biol. 2010 Jan 26;8(1):e1000286. doi: 10.1371/journal.pbio.1000286.


The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.

Navadgi-Patil VM, Burgers PM.

Mol Cell. 2009 Dec 11;36(5):743-53. doi: 10.1016/j.molcel.2009.10.014.


Dpb11 activates the Mec1-Ddc2 complex.

Mordes DA, Nam EA, Cortez D.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18730-4. doi: 10.1073/pnas.0806621105. Epub 2008 Nov 21.


Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase.

Navadgi-Patil VM, Burgers PM.

J Biol Chem. 2008 Dec 19;283(51):35853-9. doi: 10.1074/jbc.M807435200. Epub 2008 Oct 15.


Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.

Cobb JA, Schleker T, Rojas V, Bjergbaek L, Tercero JA, Gasser SM.

Genes Dev. 2005 Dec 15;19(24):3055-69.


Yet another job for Dna2: Checkpoint activation.

Wanrooij PH, Burgers PM.

DNA Repair (Amst). 2015 Aug;32:17-23. doi: 10.1016/j.dnarep.2015.04.009. Epub 2015 May 1. Review.


Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.

Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, Durocher D.

Curr Biol. 2005 Aug 9;15(15):1364-75.


Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase.

Navadgi-Patil VM, Burgers PM.

Biochem Soc Trans. 2011 Apr;39(2):600-5. doi: 10.1042/BST0390600. Review.


A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.

Navadgi-Patil VM, Burgers PM.

DNA Repair (Amst). 2009 Sep 2;8(9):996-1003. doi: 10.1016/j.dnarep.2009.03.011. Epub 2009 May 22. Review.


Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.

Clerici M, Paciotti V, Baldo V, Romano M, Lucchini G, Longhese MP.

EMBO J. 2001 Nov 15;20(22):6485-98.

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