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LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.

Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, van Bilsen M, Bakker J, Binder CJ, Lütjohann D, Staels B, Hofker MH, Shiri-Sverdlov R.

PLoS One. 2012;7(1):e30668. doi: 10.1371/journal.pone.0030668. Epub 2012 Jan 25.


Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis.

Wouters K, van Gorp PJ, Bieghs V, Gijbels MJ, Duimel H, Lütjohann D, Kerksiek A, van Kruchten R, Maeda N, Staels B, van Bilsen M, Shiri-Sverdlov R, Hofker MH.

Hepatology. 2008 Aug;48(2):474-86. doi: 10.1002/hep.22363.


The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice.

Bieghs V, Hendrikx T, van Gorp PJ, Verheyen F, Guichot YD, Walenbergh SM, Jeurissen ML, Gijbels M, Rensen SS, Bast A, Plat J, Kalhan SC, Koek GH, Leitersdorf E, Hofker MH, Lütjohann D, Shiri-Sverdlov R.

Gastroenterology. 2013 Jan;144(1):167-178.e1. doi: 10.1053/j.gastro.2012.09.062. Epub 2012 Oct 3.


Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice.

Jeurissen ML, Walenbergh SM, Houben T, Hendrikx T, Li J, Oligschlaeger Y, van Gorp PJ, Gijbels MJ, Bitorina A, Nessel I, Radtke F, Vooijs M, Theys J, Shiri-Sverdlov R.

PLoS One. 2016 Nov 29;11(11):e0167199. doi: 10.1371/journal.pone.0167199. eCollection 2016.


Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.

Bashiri A, Nesan D, Tavallaee G, Sue-Chue-Lam I, Chien K, Maguire GF, Naples M, Zhang J, Magomedova L, Adeli K, Cummins CL, Ng DS.

Biochim Biophys Acta. 2016 Jul;1861(7):594-605. doi: 10.1016/j.bbalip.2016.04.005. Epub 2016 Apr 14.


Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice.

Subramanian S, Goodspeed L, Wang S, Kim J, Zeng L, Ioannou GN, Haigh WG, Yeh MM, Kowdley KV, O'Brien KD, Pennathur S, Chait A.

J Lipid Res. 2011 Sep;52(9):1626-35. doi: 10.1194/jlr.M016246. Epub 2011 Jun 20.


Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice.

Rensen SS, Bieghs V, Xanthoulea S, Arfianti E, Bakker JA, Shiri-Sverdlov R, Hofker MH, Greve JW, Buurman WA.

PLoS One. 2012;7(12):e52411. doi: 10.1371/journal.pone.0052411. Epub 2012 Dec 20.


Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells.

Bieghs V, Verheyen F, van Gorp PJ, Hendrikx T, Wouters K, Lütjohann D, Gijbels MJ, Febbraio M, Binder CJ, Hofker MH, Shiri-Sverdlov R.

PLoS One. 2012;7(3):e34378. doi: 10.1371/journal.pone.0034378. Epub 2012 Mar 28.


Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice.

Hendrikx T, Jeurissen ML, Bieghs V, Walenbergh SM, van Gorp PJ, Verheyen F, Houben T, Guichot YD, Gijbels MJ, Leitersdorf E, Hofker MH, Lütjohann D, Shiri-Sverdlov R.

J Hepatol. 2015 Feb;62(2):430-6. doi: 10.1016/j.jhep.2014.09.027. Epub 2014 Oct 2.


A high-protein diet is anti-steatotic and has no pro-inflammatory side effects in dyslipidaemic APOE2 knock-in mice.

Garcia Caraballo SC, Comhair TM, Dejong CH, Lamers WH, Köhler SE.

Br J Nutr. 2014 Oct 28;112(8):1251-65. doi: 10.1017/S0007114514001986. Epub 2014 Aug 27.


Electronegative LDL is linked to high-fat, high-cholesterol diet-induced nonalcoholic steatohepatitis in hamsters.

Lai YS, Yang TC, Chang PY, Chang SF, Ho SL, Chen HL, Lu SC.

J Nutr Biochem. 2016 Apr;30:44-52. doi: 10.1016/j.jnutbio.2015.11.019. Epub 2015 Dec 28.


Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?

Lytle KA, Jump DB.

PLoS One. 2016 Jan 13;11(1):e0146942. doi: 10.1371/journal.pone.0146942. eCollection 2016.


Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis in obese Ldlr-/- mice.

Lytle KA, Wong CP, Jump DB.

PLoS One. 2017 Apr 19;12(4):e0173376. doi: 10.1371/journal.pone.0173376. eCollection 2017.


Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice.

Hendrikx T, Bieghs V, Walenbergh SM, van Gorp PJ, Verheyen F, Jeurissen ML, Steinbusch MM, Vaes N, Binder CJ, Koek GH, Stienstra R, Netea MG, Hofker MH, Shiri-Sverdlov R.

PLoS One. 2013 Dec 2;8(12):e78792. doi: 10.1371/journal.pone.0078792. eCollection 2013.


Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice.

Hasan ST, Zingg JM, Kwan P, Noble T, Smith D, Meydani M.

Atherosclerosis. 2014 Jan;232(1):40-51. doi: 10.1016/j.atherosclerosis.2013.10.016. Epub 2013 Oct 31.


A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein.

Yimin, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki N, Chiba H.

Lab Invest. 2012 Feb;92(2):265-81. doi: 10.1038/labinvest.2011.159. Epub 2011 Nov 7.


An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis.

Matsumoto M, Hada N, Sakamaki Y, Uno A, Shiga T, Tanaka C, Ito T, Katsume A, Sudoh M.

Int J Exp Pathol. 2013 Apr;94(2):93-103. doi: 10.1111/iep.12008. Epub 2013 Jan 11.


A metabolomic analysis of omega-3 fatty acid-mediated attenuation of western diet-induced nonalcoholic steatohepatitis in LDLR-/- mice.

Depner CM, Traber MG, Bobe G, Kensicki E, Bohren KM, Milne G, Jump DB.

PLoS One. 2013 Dec 17;8(12):e83756. doi: 10.1371/journal.pone.0083756. eCollection 2013.

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