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Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci.

Quanz M, Herbette A, Sayarath M, de Koning L, Dubois T, Sun JS, Dutreix M.

J Biol Chem. 2012 Mar 16;287(12):8803-15. doi: 10.1074/jbc.M111.320887. Epub 2012 Jan 23.


Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.

Solier S, Kohn KW, Scroggins B, Xu W, Trepel J, Neckers L, Pommier Y.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12866-72. doi: 10.1073/pnas.1203617109. Epub 2012 Jul 2.


A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM.

Curr Biol. 2000 Jul 27-Aug 10;10(15):886-95.


The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy.

Wang X, Song X, Zhuo W, Fu Y, Shi H, Liang Y, Tong M, Chang G, Luo Y.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21288-93. doi: 10.1073/pnas.0908151106. Epub 2009 Nov 24.


Thr90 phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery.

Wang X, Lu XA, Song X, Zhuo W, Jia L, Jiang Y, Luo Y.

Biochem J. 2012 Jan 1;441(1):387-97. doi: 10.1042/BJ20110855.


Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.

Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, Lee JH, Löbrich M, Paull TT, Roti Roti JL, Pandita TK.

Cancer Res. 2007 Apr 1;67(7):3010-7.


DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP.

DNA Repair (Amst). 2005 Aug 15;4(9):1006-18.


The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation.

Lu XA, Wang X, Zhuo W, Jia L, Jiang Y, Fu Y, Luo Y.

Biochem J. 2014 Jan 1;457(1):171-83. doi: 10.1042/BJ20130963.


DNA double-strand breaks and gamma-H2AX signaling in the testis.

Hamer G, Roepers-Gajadien HL, van Duyn-Goedhart A, Gademan IS, Kal HB, van Buul PP, de Rooij DG.

Biol Reprod. 2003 Feb;68(2):628-34.


Valosin-containing protein phosphorylation at Ser784 in response to DNA damage.

Livingstone M, Ruan H, Weiner J, Clauser KR, Strack P, Jin S, Williams A, Greulich H, Gardner J, Venere M, Mochan TA, DiTullio RA Jr, Moravcevic K, Gorgoulis VG, Burkhardt A, Halazonetis TD.

Cancer Res. 2005 Sep 1;65(17):7533-40.


DNA damage-induced RPA focalization is independent of gamma-H2AX and RPA hyper-phosphorylation.

Liu JS, Kuo SR, Melendy T.

J Cell Biochem. 2006 Dec 1;99(5):1452-62.


The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.

Song X, Wang X, Zhuo W, Shi H, Feng D, Sun Y, Liang Y, Fu Y, Zhou D, Luo Y.

J Biol Chem. 2010 Dec 17;285(51):40039-49. doi: 10.1074/jbc.M110.181941. Epub 2010 Oct 11.


Identification of heat shock protein 90α as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis.

Chen WS, Lee CC, Hsu YM, Chen CC, Huang TS.

Int J Colorectal Dis. 2011 Aug;26(8):1009-17. doi: 10.1007/s00384-011-1200-1. Epub 2011 Apr 26.


DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells.

Kang MJ, Jung SM, Kim MJ, Bae JH, Kim HB, Kim JY, Park SJ, Song HS, Kim DW, Kang CD, Kim SH.

FEBS J. 2008 Dec;275(23):5969-81. doi: 10.1111/j.1742-4658.2008.06725.x.


The regulatory mechanism of Hsp90alpha secretion from endothelial cells and its role in angiogenesis during wound healing.

Song X, Luo Y.

Biochem Biophys Res Commun. 2010 Jul 16;398(1):111-7. doi: 10.1016/j.bbrc.2010.06.046. Epub 2010 Jun 15.


DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

Drouet J, Delteil C, Lefrançois J, Concannon P, Salles B, Calsou P.

J Biol Chem. 2005 Feb 25;280(8):7060-9. Epub 2004 Oct 31.


The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.

Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP.

Biochemistry. 2002 Oct 22;41(42):12706-14.

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