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Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.

Plantier L, Besnard V, Xu Y, Ikegami M, Wert SE, Hunt AN, Postle AD, Whitsett JA.

J Biol Chem. 2012 Mar 23;287(13):10099-114. doi: 10.1074/jbc.M111.303669. Epub 2012 Jan 20.


Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.

Bridges JP, Schehr A, Wang Y, Huo L, Besnard V, Ikegami M, Whitsett JA, Xu Y.

PLoS One. 2014 May 7;9(5):e91376. doi: 10.1371/journal.pone.0091376. eCollection 2014.


Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.

Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA.

J Biol Chem. 2009 Feb 6;284(6):4018-30. doi: 10.1074/jbc.M805388200. Epub 2008 Dec 11.


Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS.

J Clin Invest. 2005 Sep;115(9):2489-98. Epub 2005 Aug 11.


Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.

Ng R, Wu H, Xiao H, Chen X, Willenbring H, Steer CJ, Song G.

Hepatology. 2014 Aug;60(2):554-64. doi: 10.1002/hep.27153. Epub 2014 May 19.


PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection.

Yu Y, Pierciey FJ Jr, Maguire TG, Alwine JC.

PLoS Pathog. 2013;9(4):e1003266. doi: 10.1371/journal.ppat.1003266. Epub 2013 Apr 4.


COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions.

Takashima K, Saitoh A, Funabashi T, Hirose S, Yagi C, Nozaki S, Sato R, Shin HW, Nakayama K.

J Cell Sci. 2015 Aug 1;128(15):2805-15. doi: 10.1242/jcs.164137. Epub 2015 Jun 19.


Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Fernø J, Gebhardt S, Hinney A, Remschmidt H, Krieg JC, Mehler-Wex C, Nöthen MM, Hebebrand J, Steen VM.

Mol Psychiatry. 2009 Mar;14(3):308-17. doi: 10.1038/ Epub 2008 Jan 15.


Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.

Xu Y, Ikegami M, Wang Y, Matsuzaki Y, Whitsett JA.

BMC Genomics. 2007 Dec 10;8:455.


Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes.

Inoue J, Ito Y, Shimada S, Satoh SI, Sasaki T, Hashidume T, Kamoshida Y, Shimizu M, Sato R.

FEBS J. 2011 Aug;278(15):2739-50. doi: 10.1111/j.1742-4658.2011.08204.x. Epub 2011 Jun 22.


PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.

Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y.

Nat Commun. 2015 Aug 27;6:8100. doi: 10.1038/ncomms9100.


Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway.

Chang Y, Edeen K, Lu X, De Leon M, Mason RJ.

Am J Respir Cell Mol Biol. 2006 Aug;35(2):268-74. Epub 2006 Apr 6.


Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals.

Hawkins JL, Robbins MD, Warren LC, Xia D, Petras SF, Valentine JJ, Varghese AH, Wang IK, Subashi TA, Shelly LD, Hay BA, Landschulz KT, Geoghegan KF, Harwood HJ Jr.

J Pharmacol Exp Ther. 2008 Sep;326(3):801-8. doi: 10.1124/jpet.108.139626. Epub 2008 Jun 24.


Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis.

Huber MD, Vesely PW, Datta K, Gerace L.

J Cell Biol. 2013 Nov 11;203(3):427-36. doi: 10.1083/jcb.201305076.


Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation.

Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH.

Int Immunopharmacol. 2010 Aug;10(8):906-12. doi: 10.1016/j.intimp.2010.05.001. Epub 2010 May 18.


Sterol metabolism and SREBP activation.

Sato R.

Arch Biochem Biophys. 2010 Sep 15;501(2):177-81. doi: 10.1016/ Epub 2010 Jun 10. Review.


Insulin Treatment Cannot Promote Lipogenesis in Rat Fetal Lung in Gestational Diabetes Mellitus Because of Failure to Redress the Imbalance Among SREBP-1, SCAP, and INSIG-1.

Li J, Qian G, Zhong X, Yu T.

DNA Cell Biol. 2018 Mar;37(3):264-270. doi: 10.1089/dna.2017.3906. Epub 2018 Jan 22.


Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28 days.

Yan S, Wang J, Dai J.

Arch Toxicol. 2015 Sep;89(9):1569-78. doi: 10.1007/s00204-014-1322-7. Epub 2014 Aug 6.


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