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Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation.

Mihalik SJ, Michaliszyn SF, de las Heras J, Bacha F, Lee S, Chace DH, DeJesus VR, Vockley J, Arslanian SA.

Diabetes Care. 2012 Mar;35(3):605-11. doi: 10.2337/DC11-1577. Epub 2012 Jan 20.


Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.

Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FG, DeLany JP.

Obesity (Silver Spring). 2010 Sep;18(9):1695-700. doi: 10.1038/oby.2009.510. Epub 2010 Jan 28.


Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans.

Baker PR 2nd, Boyle KE, Koves TR, Ilkayeva OR, Muoio DM, Houmard JA, Friedman JE.

Obesity (Silver Spring). 2015 May;23(5):981-8. doi: 10.1002/oby.21046. Epub 2015 Apr 10.


Postprandial changes in plasma acylcarnitine concentrations as markers of fatty acid flux in overweight and obesity.

Ramos-Roman MA, Sweetman L, Valdez MJ, Parks EJ.

Metabolism. 2012 Feb;61(2):202-12. doi: 10.1016/j.metabol.2011.06.008. Epub 2011 Aug 5.


Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women.

Adams SH, Hoppel CL, Lok KH, Zhao L, Wong SW, Minkler PE, Hwang DH, Newman JW, Garvey WT.

J Nutr. 2009 Jun;139(6):1073-81. doi: 10.3945/jn.108.103754. Epub 2009 Apr 15.


Metabolomic profiling of amino acids and β-cell function relative to insulin sensitivity in youth.

Michaliszyn SF, Sjaarda LA, Mihalik SJ, Lee S, Bacha F, Chace DH, De Jesus VR, Vockley J, Arslanian SA.

J Clin Endocrinol Metab. 2012 Nov;97(11):E2119-24. doi: 10.1210/jc.2012-2170. Epub 2012 Sep 13.


An LC-MS/MS method to quantify acylcarnitine species including isomeric and odd-numbered forms in plasma and tissues.

Giesbertz P, Ecker J, Haag A, Spanier B, Daniel H.

J Lipid Res. 2015 Oct;56(10):2029-39. doi: 10.1194/jlr.D061721. Epub 2015 Aug 3.


Fat oxidation, body composition and insulin sensitivity in diabetic and normoglycaemic obese adults 5 years after weight loss.

Poynten AM, Markovic TP, Maclean EL, Furler SM, Freund J, Chisholm DJ, Campbell LV.

Int J Obes Relat Metab Disord. 2003 Oct;27(10):1212-8.


From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation.

Bacha F, Lee S, Gungor N, Arslanian SA.

Diabetes Care. 2010 Oct;33(10):2225-31. doi: 10.2337/dc10-0004. Epub 2010 Jun 30.


Phenotypic type 2 diabetes in obese youth: insulin sensitivity and secretion in islet cell antibody-negative versus -positive patients.

Tfayli H, Bacha F, Gungor N, Arslanian S.

Diabetes. 2009 Mar;58(3):738-44. doi: 10.2337/db08-1372. Epub 2008 Dec 10.


Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy.

Lindsay KL, Hellmuth C, Uhl O, Buss C, Wadhwa PD, Koletzko B, Entringer S.

PLoS One. 2015 Dec 30;10(12):e0145794. doi: 10.1371/journal.pone.0145794. eCollection 2015.


Increased 24-h energy expenditure in type 2 diabetes.

Bitz C, Toubro S, Larsen TM, Harder H, Rennie KL, Jebb SA, Astrup A.

Diabetes Care. 2004 Oct;27(10):2416-21.


Femoral-gluteal adiposity is not associated with insulin sensitivity in type 1 diabetes.

Shay CM, Secrest AM, Miller RG, Strotmeyer ES, Goodpaster BH, Kelsey SF, Orchard TJ.

Diabet Med. 2012 Nov;29(11):1407-11. doi: 10.1111/j.1464-5491.2012.03728.x.


Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors.

Wolf M, Chen S, Zhao X, Scheler M, Irmler M, Staiger H, Beckers J, de Angelis MH, Fritsche A, Häring HU, Schleicher ED, Xu G, Lehmann R, Weigert C.

J Clin Endocrinol Metab. 2013 Jun;98(6):E1137-42. doi: 10.1210/jc.2012-3976. Epub 2013 Apr 30.


Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.

Stefan N, Kovacs P, Stumvoll M, Hanson RL, Lehn-Stefan A, Permana PA, Baier LJ, Tataranni PA, Silver K, Bogardus C.

Diabetes. 2003 Jun;52(6):1544-50.


Heat stress deteriorates mitochondrial beta-oxidation of long-chain fatty acids in cultured fibroblasts with fatty acid beta-oxidation disorders.

Li H, Fukuda S, Hasegawa Y, Purevsuren J, Kobayashi H, Mushimoto Y, Yamaguchi S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 15;878(20):1669-72. doi: 10.1016/j.jchromb.2010.01.046. Epub 2010 Feb 11.


Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers.

Marin MT, Dasari PS, Tryggestad JB, Aston CE, Teague AM, Short KR.

J Diabetes Complications. 2015 Jul;29(5):679-85. doi: 10.1016/j.jdiacomp.2015.03.015. Epub 2015 Apr 6.


Analysis of factors influencing nitrogen balance during acute starvation in obese subject with and without type 2 diabetes.

Duska F, Tůma P, Mokrejs P, Kubena A, Andel M.

Clin Nutr. 2007 Oct;26(5):552-8. Epub 2007 Mar 19.


Thiazolidinediones enhance insulin-mediated suppression of fatty acid flux in type 2 diabetes mellitus.

Racette SB, Davis AO, McGill JB, Klein S.

Metabolism. 2002 Feb;51(2):169-74.


Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS).

Kim JY, Park JY, Kim OY, Ham BM, Kim HJ, Kwon DY, Jang Y, Lee JH.

J Proteome Res. 2010 Sep 3;9(9):4368-75. doi: 10.1021/pr100101p.


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