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T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.

Fernandes RA, Shore DA, Vuong MT, Yu C, Zhu X, Pereira-Lopes S, Brouwer H, Fennelly JA, Jessup CM, Evans EJ, Wilson IA, Davis SJ.

J Biol Chem. 2012 Apr 13;287(16):13324-35. doi: 10.1074/jbc.M111.332783. Epub 2012 Jan 19.


One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop.

Ghendler Y, Smolyar A, Chang HC, Reinherz EL.

J Exp Med. 1998 May 4;187(9):1529-36.


Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.

Sun ZY, Kim ST, Kim IC, Fahmy A, Reinherz EL, Wagner G.

Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16867-72. Epub 2004 Nov 19.


Heterodimeric CD3epsilongamma extracellular domain fragments: production, purification and structural analysis.

Kim KS, Sun ZY, Wagner G, Reinherz EL.

J Mol Biol. 2000 Sep 29;302(4):899-916.


Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon.

Martínez-Martín N, Risueño RM, Morreale A, Zaldívar I, Fernández-Arenas E, Herranz F, Ortiz AR, Alarcón B.

Sci Signal. 2009 Aug 11;2(83):ra43. doi: 10.1126/scisignal.2000402.


A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling.

Wang Y, Becker D, Vass T, White J, Marrack P, Kappler JW.

PLoS Biol. 2009 Dec;7(12):e1000253. doi: 10.1371/journal.pbio.1000253. Epub 2009 Dec 1.


Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.

Wang J, Lim K, Smolyar A, Teng M, Liu J, Tse AG, Liu J, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang HC, Sacchettini JC, Reinherz EL.

EMBO J. 1998 Jan 2;17(1):10-26.


The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.

Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA, Santamaria P.

J Immunol. 2008 Jul 1;181(1):243-55.


T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.

Risueño RM, Schamel WW, Alarcón B.

PLoS One. 2008 Mar 5;3(3):e1747. doi: 10.1371/journal.pone.0001747.


Conformational changes in the T cell receptor differentially determine T cell subset development in mice.

Blanco R, Borroto A, Schamel W, Pereira P, Alarcon B.

Sci Signal. 2014 Dec 2;7(354):ra115. doi: 10.1126/scisignal.2005650.


Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.

Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA.

J Immunol. 2014 Jul 1;193(1):258-67. doi: 10.4049/jimmunol.1400322. Epub 2014 Jun 4.


Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses.

Risueño RM, Gil D, Fernández E, Sánchez-Madrid F, Alarcón B.

Blood. 2005 Jul 15;106(2):601-8. Epub 2005 Mar 24.


CD2 and CD3 receptor-mediated tolerance: constraints on T cell activation.

Punch JD, Lin J, Bluestone J, Bromberg JS.

Transplantation. 1999 Mar 15;67(5):741-8.


Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.

Gagnon E, Schubert DA, Gordo S, Chu HH, Wucherpfennig KW.

J Exp Med. 2012 Dec 17;209(13):2423-39. doi: 10.1084/jem.20120790. Epub 2012 Nov 19.


Expression and characterization of recombinant soluble human CD3 molecules: presentation of antigenic epitopes defined on the native TCR-CD3 complex.

Law CL, Hayden-Ledbetter M, Buckwalter S, McNeill L, Nguyen H, Habecker P, Thorne BA, Dua R, Ledbetter JA.

Int Immunol. 2002 Apr;14(4):389-400.


Signals transduced by CD3epsilon, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro.

Carleton M, Ruetsch NR, Berger MA, Rhodes M, Kaptik S, Wiest DL.

J Immunol. 1999 Sep 1;163(5):2576-85.


CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells.

Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T.

J Biol Chem. 1999 Jun 25;274(26):18173-80.


Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution.

Shore DA, Teyton L, Dwek RA, Rudd PM, Wilson IA.

J Mol Biol. 2006 Apr 28;358(2):347-54. Epub 2006 Feb 23.


TCRs genetically linked to CD28 and CD3ε do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity.

Govers C, Sebestyén Z, Roszik J, van Brakel M, Berrevoets C, Szöőr Á, Panoutsopoulou K, Broertjes M, Van T, Vereb G, Szöllősi J, Debets R.

J Immunol. 2014 Nov 15;193(10):5315-26. doi: 10.4049/jimmunol.1302074. Epub 2014 Oct 15.

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