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Items: 1 to 20 of 149

1.

RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice.

Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, Sevick-Muraca E, King PD.

J Clin Invest. 2012 Feb;122(2):733-47. doi: 10.1172/JCI46116. Epub 2012 Jan 9.

2.

RASA1 regulates the function of lymphatic vessel valves in mice.

Lapinski PE, Lubeck BA, Chen D, Doosti A, Zawieja SD, Davis MJ, King PD.

J Clin Invest. 2017 Jun 30;127(7):2569-2585. doi: 10.1172/JCI89607. Epub 2017 May 22.

3.

Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation.

Lubeck BA, Lapinski PE, Bauler TJ, Oliver JA, Hughes ED, Saunders TL, King PD.

Am J Pathol. 2014 Dec;184(12):3163-9. doi: 10.1016/j.ajpath.2014.08.018. Epub 2014 Oct 3.

4.

Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein.

Lapinski PE, Bauler TJ, Brown EJ, Hughes ED, Saunders TL, King PD.

Genesis. 2007 Dec;45(12):762-7.

5.

Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.

Lohela M, Heloterä H, Haiko P, Dumont DJ, Alitalo K.

Am J Pathol. 2008 Dec;173(6):1891-901. doi: 10.2353/ajpath.2008.080378. Epub 2008 Nov 6.

6.

A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells.

Lapinski PE, Qiao Y, Chang CH, King PD.

J Immunol. 2011 Jul 1;187(1):151-63. doi: 10.4049/jimmunol.1100178. Epub 2011 Jun 6.

7.

Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man.

Burrows PE, Gonzalez-Garay ML, Rasmussen JC, Aldrich MB, Guilliod R, Maus EA, Fife CE, Kwon S, Lapinski PE, King PD, Sevick-Muraca EM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8621-6. doi: 10.1073/pnas.1222722110. Epub 2013 May 6.

8.

H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.

Ichise T, Yoshida N, Ichise H.

Development. 2010 Mar;137(6):1003-13. doi: 10.1242/dev.043489.

9.

RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity.

Kawasaki J, Aegerter S, Fevurly RD, Mammoto A, Mammoto T, Sahin M, Mably JD, Fishman SJ, Chan J.

J Clin Invest. 2014 Jun;124(6):2774-84. doi: 10.1172/JCI67084. Epub 2014 May 16.

10.

Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.

Karpanen T, Wirzenius M, Mäkinen T, Veikkola T, Haisma HJ, Achen MG, Stacker SA, Pytowski B, Ylä-Herttuala S, Alitalo K.

Am J Pathol. 2006 Aug;169(2):708-18.

11.
12.

Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells.

Qin TT, Xu GC, Qi JW, Yang GL, Zhang K, Liu HL, Xu LX, Xiang R, Xiao G, Cao H, Wei Y, Zhang QZ, Li LY.

J Pathol. 2015 Nov;237(3):307-18. doi: 10.1002/path.4577. Epub 2015 Aug 6.

PMID:
26096340
13.

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway.

Yu J, Zhang X, Kuzontkoski PM, Jiang S, Zhu W, Li DY, Groopman JE.

Cell Commun Signal. 2014 Apr 7;12:25. doi: 10.1186/1478-811X-12-25.

14.

MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1).

Sun D, Yu F, Ma Y, Zhao R, Chen X, Zhu J, Zhang CY, Chen J, Zhang J.

J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.

15.

Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium.

Dellinger MT, Brekken RA.

PLoS One. 2011;6(12):e28947. doi: 10.1371/journal.pone.0028947. Epub 2011 Dec 12.

16.

HIV-1 matrix protein p17 promotes lymphangiogenesis and activates the endothelin-1/endothelin B receptor axis.

Caccuri F, Rueckert C, Giagulli C, Schulze K, Basta D, Zicari S, Marsico S, Cervi E, Fiorentini S, Slevin M, Guzman CA, Caruso A.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):846-56. doi: 10.1161/ATVBAHA.113.302478. Epub 2014 Jan 30.

17.

Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis.

Hos D, Regenfuss B, Bock F, Onderka J, Cursiefen C.

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5778-85. doi: 10.1167/iovs.10-6816.

PMID:
21666240
18.

The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors.

Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G.

Genes Dev. 2014 Oct 1;28(19):2175-87. doi: 10.1101/gad.216226.113.

19.

Vascular endothelial growth factor receptor-3 directly interacts with phosphatidylinositol 3-kinase to regulate lymphangiogenesis.

Coso S, Zeng Y, Opeskin K, Williams ED.

PLoS One. 2012;7(6):e39558. doi: 10.1371/journal.pone.0039558. Epub 2012 Jun 22.

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