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Nuclear factor-κB (NF-κB) inhibitory protein IκBβ determines apoptotic cell death following exposure to oxidative stress.

Wright CJ, Agboke F, Muthu M, Michaelis KA, Mundy MA, La P, Yang G, Dennery PA.

J Biol Chem. 2012 Feb 24;287(9):6230-9. doi: 10.1074/jbc.M111.318246. Epub 2012 Jan 5.


IκBβ attenuates angiotensin II-induced cardiovascular inflammation and fibrosis in mice.

Xu S, Zhi H, Hou X, Cohen RA, Jiang B.

Hypertension. 2011 Aug;58(2):310-6. doi: 10.1161/HYPERTENSIONAHA.111.172031. Epub 2011 Jun 6.


IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation.

Fan C, Li Q, Zhang Y, Liu X, Luo M, Abbott D, Zhou W, Engelhardt JF.

J Clin Invest. 2004 Mar;113(5):746-55.


Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity.

Tergaonkar V, Correa RG, Ikawa M, Verma IM.

Nat Cell Biol. 2005 Sep;7(9):921-3.


p65 controls NF-κB activity by regulating cellular localization of IκBβ.

Valovka T, Hottiger MO.

Biochem J. 2011 Mar 1;434(2):253-63. doi: 10.1042/BJ20101220.


Sustained hyperoxia-induced NF-κB activation improves survival and preserves lung development in neonatal mice.

McKenna S, Michaelis KA, Agboke F, Liu T, Han K, Yang G, Dennery PA, Wright CJ.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1078-89. doi: 10.1152/ajplung.00001.2014. Epub 2014 Apr 18.


IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response.

Rao P, Hayden MS, Long M, Scott ML, West AP, Zhang D, Oeckinghaus A, Lynch C, Hoffmann A, Baltimore D, Ghosh S.

Nature. 2010 Aug 26;466(7310):1115-9. doi: 10.1038/nature09283.


RelA/p65 regulation of IkappaBbeta.

Hertlein E, Wang J, Ladner KJ, Bakkar N, Guttridge DC.

Mol Cell Biol. 2005 Jun;25(12):4956-68.


IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury.

Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ.

Am J Respir Cell Mol Biol. 2014 Feb;50(2):429-38. doi: 10.1165/rcmb.2013-0303OC.


Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages.

McKenna S, Gossling M, Bugarini A, Hill E, Anderson AL, Rancourt RC, Balasubramaniyan N, El Kasmi KC, Wright CJ.

J Immunol. 2015 Oct 15;195(8):3866-79. doi: 10.4049/jimmunol.1501017. Epub 2015 Sep 4.


Inhibiting IκBβ-NFκB signaling attenuates the expression of select pro-inflammatory genes.

McKenna S, Wright CJ.

J Cell Sci. 2015 Jun 1;128(11):2143-55. doi: 10.1242/jcs.168351. Epub 2015 Apr 23.


Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes.

De Plaen IG, Qu XW, Wang H, Tan XD, Wang L, Han XB, Rozenfeld RA, Hsueh W.

Immunology. 2002 Aug;106(4):577-83.


A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.

Biswas G, Tang W, Sondheimer N, Guha M, Bansal S, Avadhani NG.

J Biol Chem. 2008 May 2;283(18):12586-94. doi: 10.1074/jbc.M710481200. Epub 2008 Feb 13.


Functional dichotomy of A20 in apoptotic and necrotic cell death.

Storz P, Döppler H, Ferran C, Grey ST, Toker A.

Biochem J. 2005 Apr 1;387(Pt 1):47-55.


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