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Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice.

Qin S, Liu M, Niu W, Zhang CL.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21117-21. doi: 10.1073/pnas.1112351109.


Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice.

Lang B, Song B, Davidson W, MacKenzie A, Smith N, McCaig CD, Harmar AJ, Shen S.

J Clin Invest. 2006 Jul;116(7):1924-34.


Role of Kruppel-like factor 4 in neurogenesis and radial neuronal migration in the developing cerebral cortex.

Qin S, Zhang CL.

Mol Cell Biol. 2012 Nov;32(21):4297-305. doi: 10.1128/MCB.00838-12.


Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.

Aksoy I, Giudice V, Delahaye E, Wianny F, Aubry M, Mure M, Chen J, Jauch R, Bogu GK, Nolden T, Himmelbauer H, Xavier Doss M, Sachinidis A, Schulz H, Hummel O, Martinelli P, Hübner N, Stanton LW, Real FX, Bourillot PY, Savatier P.

Nat Commun. 2014 Apr 28;5:3719. doi: 10.1038/ncomms4719.


MicroRNA-137 represses Klf4 and Tbx3 during differentiation of mouse embryonic stem cells.

Jiang K, Ren C, Nair VD.

Stem Cell Res. 2013 Nov;11(3):1299-313. doi: 10.1016/j.scr.2013.09.001.


Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency.

Son MY, Choi H, Han YM, Cho YS.

Stem Cells. 2013 Nov;31(11):2374-87. doi: 10.1002/stem.1509.


Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene.

Ghaleb AM, McConnell BB, Kaestner KH, Yang VW.

Dev Biol. 2011 Jan 15;349(2):310-20. doi: 10.1016/j.ydbio.2010.11.001.


Expression of Kruppel-like factor KLF4 in mouse hair follicle stem cells contributes to cutaneous wound healing.

Li J, Zheng H, Wang J, Yu F, Morris RJ, Wang TC, Huang S, Ai W.

PLoS One. 2012;7(6):e39663. doi: 10.1371/journal.pone.0039663.


Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX.

Vidovic D, Harris L, Harvey TJ, Evelyn Heng YH, Smith AG, Osinski J, Hughes J, Thomas P, Gronostajski RM, Bailey TL, Piper M.

Brain Res. 2015 Aug 7;1616:71-87. doi: 10.1016/j.brainres.2015.04.057.


Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.

Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y.

Cell Stem Cell. 2008 Nov 6;3(5):555-67. doi: 10.1016/j.stem.2008.09.003.


Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation.

Tahmasebi S, Ghorbani M, Savage P, Yan K, Gocevski G, Xiao L, You L, Yang XJ.

J Biol Chem. 2013 May 3;288(18):12791-804. doi: 10.1074/jbc.M113.465443.


MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.

Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS.

Cell. 2009 May 15;137(4):647-58. doi: 10.1016/j.cell.2009.02.038.


Two factor reprogramming of human neural stem cells into pluripotency.

Hester ME, Song S, Miranda CJ, Eagle A, Schwartz PH, Kaspar BK.

PLoS One. 2009 Sep 18;4(9):e7044. doi: 10.1371/journal.pone.0007044.


Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator.

Fujii Y, Kakegawa M, Koide H, Akagi T, Yokota T.

Biochem Biophys Res Commun. 2013 Nov 15;441(2):411-7. doi: 10.1016/j.bbrc.2013.10.073.


Krüppel-like factor 4 regulates membranous and endochondral ossification.

Michikami I, Fukushi T, Tanaka M, Egusa H, Maeda Y, Ooshima T, Wakisaka S, Abe M.

Exp Cell Res. 2012 Feb 15;318(4):311-25. doi: 10.1016/j.yexcr.2011.12.013.


Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis.

Li J, Zheng H, Yu F, Yu T, Liu C, Huang S, Wang TC, Ai W.

Carcinogenesis. 2012 Jun;33(6):1239-46. doi: 10.1093/carcin/bgs143.


The Krüppel-like factor 2 and Krüppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis.

Chiplunkar AR, Curtis BC, Eades GL, Kane MS, Fox SJ, Haar JL, Lloyd JA.

BMC Dev Biol. 2013 Nov 22;13:40. doi: 10.1186/1471-213X-13-40.


Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages.

Li IC, Chan CT, Lu YF, Wu YT, Chen YC, Li GB, Lin CY, Hwang SP.

PLoS One. 2011;6(6):e20974. doi: 10.1371/journal.pone.0020974.


ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

Kim MO, Kim SH, Cho YY, Nadas J, Jeong CH, Yao K, Kim DJ, Yu DH, Keum YS, Lee KY, Huang Z, Bode AM, Dong Z.

Nat Struct Mol Biol. 2012 Feb 5;19(3):283-90. doi: 10.1038/nsmb.2217.


Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells.

Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC.

Stem Cells. 2010 Sep;28(9):1510-7. doi: 10.1002/stem.477.

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