Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 390

1.

A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.

White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M.

Epilepsia. 2012 Jan;53(1):134-46. doi: 10.1111/j.1528-1167.2011.03338.x. Epub 2011 Dec 9. Erratum in: Epilepsia. 2012 Feb;53(2):397.

2.

Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus.

Shekh-Ahmad T, Hen N, McDonough JH, Yagen B, Bialer M.

Epilepsia. 2013 Sep;54 Suppl 6:99-102. doi: 10.1111/epi.12290.

3.

The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus.

Shekh-Ahmad T, Mawasi H, McDonough JH, Yagen B, Bialer M.

Epilepsy Behav. 2015 Aug;49:298-302. doi: 10.1016/j.yebeh.2015.04.012. Epub 2015 May 13. Review.

PMID:
25979572
4.

Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential.

Shekh-Ahmad T, Hen N, Yagen B, McDonough JH, Finnell RH, Wlodarczyk BJ, Bialer M.

Epilepsia. 2014 Feb;55(2):353-61. doi: 10.1111/epi.12480. Epub 2013 Dec 6.

5.

A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.

Pouliot W, Bialer M, Hen N, Shekh-Ahmad T, Kaufmann D, Yagen B, Ricks K, Roach B, Nelson C, Dudek FE.

Neuroscience. 2013 Feb 12;231:145-56. doi: 10.1016/j.neuroscience.2012.11.005. Epub 2012 Nov 14.

PMID:
23159312
6.

Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide--Amide derivatives of valproic acid.

Mawasi H, Shekh-Ahmad T, Finnell RH, Wlodarczyk BJ, Bialer M.

Epilepsy Behav. 2015 May;46:72-8. doi: 10.1016/j.yebeh.2015.02.040. Epub 2015 Apr 8.

PMID:
25863940
7.

sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats.

Bar-Klein G, Swissa E, Kamintsky L, Shekh-Ahmad T, Saar-Ashkenazy R, Hubary Y, Shrot S, Stetlander L, Eisenkraft A, Friedman A, Bialer M.

Epilepsia. 2014 Dec;55(12):1953-8. doi: 10.1111/epi.12838. Epub 2014 Nov 6.

8.

Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid.

Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, Bialer M.

Epilepsia. 2014 Dec;55(12):1944-52. doi: 10.1111/epi.12857. Epub 2014 Nov 29.

9.

Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus.

Hen N, Shekh-Ahmad T, Yagen B, McDonough JH, Finnell RH, Wlodarczyk B, Bialer M.

J Med Chem. 2013 Aug 22;56(16):6467-77. doi: 10.1021/jm4007565. Epub 2013 Aug 7.

PMID:
23879329
10.

Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.

Isoherranen N, White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M.

Pharm Res. 2003 Aug;20(8):1293-301.

PMID:
12948028
11.

Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.

Pessah N, Yagen B, Hen N, Shimshoni JA, Wlodarczyk B, Finnell RH, Bialer M.

Epilepsy Behav. 2011 Nov;22(3):461-8. doi: 10.1016/j.yebeh.2011.08.026. Epub 2011 Sep 29.

PMID:
21959082
12.

Pharmacokinetic-Pharmacodynamic Correlation and Brain Penetration of sec-Butylpropylacetamide, a New CNS Drug Possessing Unique Activity against Status Epilepticus.

Mawasi H, Bibi D, Shekh-Ahmad T, Shaul C, Blotnik S, Bialer M.

Mol Pharm. 2016 Jul 5;13(7):2492-6. doi: 10.1021/acs.molpharmaceut.6b00221. Epub 2016 Jun 2.

PMID:
27218460
13.

Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents.

Isoherranen N, Yagen B, Woodhead JH, Spiegelstein O, Blotnik S, Wilcox KS, Finnell RH, Bennett GD, White HS, Bialer M.

Br J Pharmacol. 2003 Feb;138(4):602-13.

14.

Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.

Trandafir CC, Pouliot WA, Dudek FE, Ekstrand JJ.

Neuroscience. 2015 Jan 22;284:601-10. doi: 10.1016/j.neuroscience.2014.10.021. Epub 2014 Oct 18.

15.

[Prevention and treatment of status epilepticus induced by soman].

Blanchet G, Carpentier P, Lallement G, Sentenac-Roumanou H.

Ann Pharm Fr. 1994;52(1):11-24. French.

PMID:
8085742
16.

Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure.

Rossetti F, de Araujo Furtado M, Pak T, Bailey K, Shields M, Chanda S, Addis M, Robertson BD, Moffett M, Lumley LA, Yourick DL.

Neurotoxicology. 2012 Jun;33(3):500-11. doi: 10.1016/j.neuro.2012.02.010. Epub 2012 Feb 24.

PMID:
22387230
17.

Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: a potential for a second generation drug to valproic acid.

Shimshoni JA, Yagen B, Pessah N, Wlodarczyk B, Finnell RH, Bialer M.

Epilepsia. 2008 Jul;49(7):1202-12. doi: 10.1111/j.1528-1167.2008.01624.x.

18.

Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats.

Brandt C, Gastens AM, Sun Mz, Hausknecht M, Löscher W.

Neuropharmacology. 2006 Sep;51(4):789-804. Epub 2006 Jun 27.

PMID:
16806297
19.

Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.

Shimshoni JA, Yagen B, Wlodarczyk B, Finnell RH, Schurig V, Bialer M.

Epilepsia. 2010 Mar;51(3):323-32. doi: 10.1111/j.1528-1167.2009.02241.x. Epub 2009 Aug 8.

20.

The Role of Gastrodin on Hippocampal Neurons after N-Methyl-D-Aspartate Excitotoxicity and Experimental Temporal Lobe Seizures.

Wong SB, Hung WC, Min MY.

Chin J Physiol. 2016 Jun 30;59(3):156-64. doi: 10.4077/CJP.2016.BAE385.

PMID:
27188468

Supplemental Content

Support Center