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Items: 1 to 20 of 110


Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation.

Narayanan A, LeClaire LL 3rd, Barber DL, Jacobson MP.

PLoS Comput Biol. 2011 Nov;7(11):e1002226. doi: 10.1371/journal.pcbi.1002226. Epub 2011 Nov 10.


Molecular dynamics simulations of Arp2/3 complex activation.

Dalhaimer P, Pollard TD.

Biophys J. 2010 Oct 20;99(8):2568-76. doi: 10.1016/j.bpj.2010.08.027.


Characterization of two classes of small molecule inhibitors of Arp2/3 complex.

Nolen BJ, Tomasevic N, Russell A, Pierce DW, Jia Z, McCormick CD, Hartman J, Sakowicz R, Pollard TD.

Nature. 2009 Aug 20;460(7258):1031-4. doi: 10.1038/nature08231. Epub 2009 Aug 2.


The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation.

Balcer HI, Daugherty-Clarke K, Goode BL.

J Biol Chem. 2010 Mar 12;285(11):8481-91. doi: 10.1074/jbc.M109.054957. Epub 2010 Jan 12.


Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments.

LeClaire LL 3rd, Baumgartner M, Iwasa JH, Mullins RD, Barber DL.

J Cell Biol. 2008 Aug 25;182(4):647-54. doi: 10.1083/jcb.200802145.


An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability.

Goley ED, Rammohan A, Znameroski EA, Firat-Karalar EN, Sept D, Welch MD.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8159-64. doi: 10.1073/pnas.0911668107. Epub 2010 Apr 19.


Key structural features of the actin filament Arp2/3 complex branch junction revealed by molecular simulation.

Pfaendtner J, Volkmann N, Hanein D, Dalhaimer P, Pollard TD, Voth GA.

J Mol Biol. 2012 Feb 10;416(1):148-61. doi: 10.1016/j.jmb.2011.12.025. Epub 2011 Dec 17.


The role of viral protein Ac34 in nuclear relocation of subunits of the actin-related protein 2/3 complex.

Mu J, Zhang Y, Hu Y, Hu X, Zhou Y, Chen X, Wang Y.

Virol Sin. 2016 Dec;31(6):480-489. doi: 10.1007/s12250-016-3912-4. Epub 2016 Dec 5.


The structural basis of actin filament branching by the Arp2/3 complex.

Rouiller I, Xu XP, Amann KJ, Egile C, Nickell S, Nicastro D, Li R, Pollard TD, Volkmann N, Hanein D.

J Cell Biol. 2008 Mar 10;180(5):887-95. doi: 10.1083/jcb.200709092. Epub 2008 Mar 3.


Arp2/3 complex ATP hydrolysis promotes lamellipodial actin network disassembly but is dispensable for assembly.

Ingerman E, Hsiao JY, Mullins RD.

J Cell Biol. 2013 Mar 4;200(5):619-33. doi: 10.1083/jcb.201211069. Epub 2013 Feb 25.


Molecular analysis of Arp2/3 complex activation in cells.

Galletta BJ, Carlsson AE, Cooper JA.

Biophys J. 2012 Nov 21;103(10):2145-56. doi: 10.1016/j.bpj.2012.10.009. Epub 2012 Nov 20.


Molecular dynamics simulation and coarse-grained analysis of the Arp2/3 complex.

Pfaendtner J, Voth GA.

Biophys J. 2008 Dec;95(11):5324-33. doi: 10.1529/biophysj.108.143313. Epub 2008 Sep 19.


Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex.

Rodnick-Smith M, Luan Q, Liu SL, Nolen BJ.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3834-43. doi: 10.1073/pnas.1517798113. Epub 2016 Jun 20.


Nucleotide- and activator-dependent structural and dynamic changes of arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry.

Zencheck WD, Xiao H, Nolen BJ, Angeletti RH, Pollard TD, Almo SC.

J Mol Biol. 2009 Jul 17;390(3):414-27. doi: 10.1016/j.jmb.2009.03.028. Epub 2009 Mar 17.


Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs.

Boczkowska M, Rebowski G, Kast DJ, Dominguez R.

Nat Commun. 2014;5:3308. doi: 10.1038/ncomms4308.


The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit.

LeClaire LL, Rana M, Baumgartner M, Barber DL.

J Cell Biol. 2015 Jan 19;208(2):161-70. doi: 10.1083/jcb.201404095.


Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex.

Liu SL, May JR, Helgeson LA, Nolen BJ.

J Biol Chem. 2013 Jan 4;288(1):487-97. doi: 10.1074/jbc.M112.406744. Epub 2012 Nov 12.


Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry.

Kiselar JG, Mahaffy R, Pollard TD, Almo SC, Chance MR.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1552-7. Epub 2007 Jan 24.


Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex.

Ti SC, Jurgenson CT, Nolen BJ, Pollard TD.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):E463-71. doi: 10.1073/pnas.1100125108. Epub 2011 Jun 15.

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