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Items: 1 to 20 of 97


Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue.

Suloway CJ, Rome ME, Clemons WM Jr.

EMBO J. 2012 Feb 1;31(3):707-19. doi: 10.1038/emboj.2011.433. Epub 2011 Nov 29.


Get1 stabilizes an open dimer conformation of get3 ATPase by binding two distinct interfaces.

Kubota K, Yamagata A, Sato Y, Goto-Ito S, Fukai S.

J Mol Biol. 2012 Sep 21;422(3):366-75. doi: 10.1016/j.jmb.2012.05.045. Epub 2012 Jun 7.


Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.

Mateja A, Paduch M, Chang HY, Szydlowska A, Kossiakoff AA, Hegde RS, Keenan RJ.

Science. 2015 Mar 6;347(6226):1152-5. doi: 10.1126/science.1261671.


The crystal structures of yeast Get3 suggest a mechanism for tail-anchored protein membrane insertion.

Hu J, Li J, Qian X, Denic V, Sha B.

PLoS One. 2009 Nov 30;4(11):e8061. doi: 10.1371/journal.pone.0008061.


The structural basis of tail-anchored membrane protein recognition by Get3.

Mateja A, Szlachcic A, Downing ME, Dobosz M, Mariappan M, Hegde RS, Keenan RJ.

Nature. 2009 Sep 17;461(7262):361-6. doi: 10.1038/nature08319. Epub 2009 Aug 12.


Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.

Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I.

Science. 2011 Aug 5;333(6043):758-62. doi: 10.1126/science.1207125. Epub 2011 Jun 30.


Nucleotide-dependent mechanism of Get3 as elucidated from free energy calculations.

Wereszczynski J, McCammon JA.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7759-64. doi: 10.1073/pnas.1117441109. Epub 2012 Apr 30.


Structural characterization of the Get4/Get5 complex and its interaction with Get3.

Chartron JW, Suloway CJ, Zaslaver M, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12127-32. doi: 10.1073/pnas.1006036107. Epub 2010 Jun 16.


Structural insight into the membrane insertion of tail-anchored proteins by Get3.

Yamagata A, Mimura H, Sato Y, Yamashita M, Yoshikawa A, Fukai S.

Genes Cells. 2010 Jan;15(1):29-41. doi: 10.1111/j.1365-2443.2009.01362.x. Epub 2009 Dec 15.


Model for eukaryotic tail-anchored protein binding based on the structure of Get3.

Suloway CJ, Chartron JW, Zaslaver M, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14849-54. doi: 10.1073/pnas.0907522106. Epub 2009 Aug 14.


The mechanism of tail-anchored protein insertion into the ER membrane.

Wang F, Whynot A, Tung M, Denic V.

Mol Cell. 2011 Sep 2;43(5):738-50. doi: 10.1016/j.molcel.2011.07.020. Epub 2011 Aug 11.


Preliminary X-ray crystallographic studies of yeast Get3.

Hu J, Li J, Qian X, Jin Z, Fu Z, Sha B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 1;65(Pt 5):489-91. doi: 10.1107/S1744309109012317. Epub 2009 Apr 24.


Precise timing of ATPase activation drives targeting of tail-anchored proteins.

Rome ME, Rao M, Clemons WM, Shan SO.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7666-71. doi: 10.1073/pnas.1222054110. Epub 2013 Apr 22.


Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.

Gristick HB, Rao M, Chartron JW, Rome ME, Shan SO, Clemons WM Jr.

Nat Struct Mol Biol. 2014 May;21(5):437-42. doi: 10.1038/nsmb.2813. Epub 2014 Apr 13.


Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting.

Simpson PJ, Schwappach B, Dohlman HG, Isaacson RL.

Structure. 2010 Aug 11;18(8):897-902. doi: 10.1016/j.str.2010.07.003. Review.


Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.

Chang YW, Lin TW, Li YC, Huang YS, Sun YJ, Hsiao CD.

J Biol Chem. 2012 Feb 10;287(7):4783-9. doi: 10.1074/jbc.M111.318329. Epub 2011 Dec 21.


Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway.

Denic V, Dötsch V, Sinning I.

Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a013334. doi: 10.1101/cshperspect.a013334. Review.


Mechanism of Assembly of a Substrate Transfer Complex during Tail-anchored Protein Targeting.

Gristick HB, Rome ME, Chartron JW, Rao M, Hess S, Shan SO, Clemons WM Jr.

J Biol Chem. 2015 Dec 11;290(50):30006-17. doi: 10.1074/jbc.M115.677328. Epub 2015 Oct 7.


Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway.

Rome ME, Chio US, Rao M, Gristick H, Shan SO.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4929-35. doi: 10.1073/pnas.1411284111. Epub 2014 Nov 3.


The GET complex mediates insertion of tail-anchored proteins into the ER membrane.

Schuldiner M, Metz J, Schmid V, Denic V, Rakwalska M, Schmitt HD, Schwappach B, Weissman JS.

Cell. 2008 Aug 22;134(4):634-45. doi: 10.1016/j.cell.2008.06.025.

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